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Effects of exercise after focal cerebral cortex infarction on basal ganglion.

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Title: Effects of exercise after focal cerebral cortex infarction on basal ganglion.
Authors: Mizutani, Kenmei, Sonoda, Shigeru, Karasawa, Nobuyuki, Yamada, Keiki, Shimpo, Kan, Chihara, Takeshi, Takeuchi, Terumi, Hasegawa, Yoko, Kubo, Kin-ya
Source: Neurological Sciences. Jun2013, Vol. 34 Issue 6, p861-867. 7p. 1 Black and White Photograph, 3 Graphs.
Subjects: Exercise physiology, Cerebral infarction, Basal ganglia, Movement disorders, Stroke, Medical rehabilitation, Immunohistochemistry
Abstract: Identification of functional molecules in the brain related to improvement of motor dysfunction after stroke will contribute to establish a new treatment strategy for stroke rehabilitation. Hence, monoamine changes in basal ganglion related to motor control were examined in groups with/without voluntary exercise after cerebral infarction. Cerebral infarction was produced by photothrombosis in rats. Voluntary exercise using a running wheel was initiated from 2 days after surgery. Motor performance was measured by the accelerated rotarod test. Monoamine concentrations in striatum were analyzed using HPLC and immunohistochemical staining performed with anti-tyrosine hydroxylase antibody. In behavioral evaluation, the mean latency until falling from the rotating rod in the group with exercise (infarction-EX group) was significantly longer than that in the group without exercise (infarction-CNT group). When concerning the alteration of monoamine concentration between before and 2 days after infarction, dopamine level showed a significant increase 2 days after infarction. Subsequently, dopamine level was significantly decreased in the infarction-EX group at 10 days after infarction; in contrast, both norepinephrine and 5-HT concentrations were significantly higher in the infarction-EX group than in the infarction-CNT group. Furthermore, duration of rotarod test showed a significant inverse correlation with dopamine levels and a significant positive correlation with 5-HT levels. In immunohistochemical analysis, tyrosine hydroxylase immunoreactivity in substantia nigra pars compacta was shown to increase in the infarction-CNT group. In the present study, at least some of the alterations of monoamines associated with the improvement of paralysis in the basal ganglion related to motor control might have been detected. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Effects of exercise after focal cerebral cortex infarction on basal ganglion.
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  Data: <searchLink fieldCode="AR" term="%22Mizutani%2C+Kenmei%22">Mizutani, Kenmei</searchLink><br /><searchLink fieldCode="AR" term="%22Sonoda%2C+Shigeru%22">Sonoda, Shigeru</searchLink><br /><searchLink fieldCode="AR" term="%22Karasawa%2C+Nobuyuki%22">Karasawa, Nobuyuki</searchLink><br /><searchLink fieldCode="AR" term="%22Yamada%2C+Keiki%22">Yamada, Keiki</searchLink><br /><searchLink fieldCode="AR" term="%22Shimpo%2C+Kan%22">Shimpo, Kan</searchLink><br /><searchLink fieldCode="AR" term="%22Chihara%2C+Takeshi%22">Chihara, Takeshi</searchLink><br /><searchLink fieldCode="AR" term="%22Takeuchi%2C+Terumi%22">Takeuchi, Terumi</searchLink><br /><searchLink fieldCode="AR" term="%22Hasegawa%2C+Yoko%22">Hasegawa, Yoko</searchLink><br /><searchLink fieldCode="AR" term="%22Kubo%2C+Kin-ya%22">Kubo, Kin-ya</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Jun2013, Vol. 34 Issue 6, p861-867. 7p. 1 Black and White Photograph, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Exercise+physiology%22">Exercise physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+infarction%22">Cerebral infarction</searchLink><br /><searchLink fieldCode="DE" term="%22Basal+ganglia%22">Basal ganglia</searchLink><br /><searchLink fieldCode="DE" term="%22Movement+disorders%22">Movement disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke%22">Stroke</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+rehabilitation%22">Medical rehabilitation</searchLink><br /><searchLink fieldCode="DE" term="%22Immunohistochemistry%22">Immunohistochemistry</searchLink>
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  Data: Identification of functional molecules in the brain related to improvement of motor dysfunction after stroke will contribute to establish a new treatment strategy for stroke rehabilitation. Hence, monoamine changes in basal ganglion related to motor control were examined in groups with/without voluntary exercise after cerebral infarction. Cerebral infarction was produced by photothrombosis in rats. Voluntary exercise using a running wheel was initiated from 2 days after surgery. Motor performance was measured by the accelerated rotarod test. Monoamine concentrations in striatum were analyzed using HPLC and immunohistochemical staining performed with anti-tyrosine hydroxylase antibody. In behavioral evaluation, the mean latency until falling from the rotating rod in the group with exercise (infarction-EX group) was significantly longer than that in the group without exercise (infarction-CNT group). When concerning the alteration of monoamine concentration between before and 2 days after infarction, dopamine level showed a significant increase 2 days after infarction. Subsequently, dopamine level was significantly decreased in the infarction-EX group at 10 days after infarction; in contrast, both norepinephrine and 5-HT concentrations were significantly higher in the infarction-EX group than in the infarction-CNT group. Furthermore, duration of rotarod test showed a significant inverse correlation with dopamine levels and a significant positive correlation with 5-HT levels. In immunohistochemical analysis, tyrosine hydroxylase immunoreactivity in substantia nigra pars compacta was shown to increase in the infarction-CNT group. In the present study, at least some of the alterations of monoamines associated with the improvement of paralysis in the basal ganglion related to motor control might have been detected. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Jun2013
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