Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG.
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| Title: | Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG. |
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| Authors: | Lei, Saobo, Jackson, Michael F., Jia, Zhengping, Roder, John, Bai, Donglin, Orser, Beverley A., MacDonald, John F. |
| Source: | Nature Neuroscience. Jun2000, Vol. 3 Issue 6, p559. 7p. |
| Subjects: | Protein kinases, Neural transmission |
| Abstract: | In central neurons, the second messenger cGMP is believed to induce long-term changes in efficacy at glutamatergic synapses through activation of protein kinase G (PKG). Stimulating nitric oxide synthase, activating soluble guanylyl cyclase or elevating concentrations of intracellular cGMP depressed excitatory synaptic transmission in CA1 hippocampal neurons. Unexpectedly, intracellular cGMP depressed responses of AMPA receptors and inhibited excitatory postsynaptic currents in hippocampal neurons independently of phosphorylation. Our findings demonstrate that cGMP's modulation of excitatory transmission may involve a coupling of AMPA channel activity to levels of cGMP. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 8829621 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lei%2C+Saobo%22">Lei, Saobo</searchLink><br /><searchLink fieldCode="AR" term="%22Jackson%2C+Michael+F%2E%22">Jackson, Michael F.</searchLink><br /><searchLink fieldCode="AR" term="%22Jia%2C+Zhengping%22">Jia, Zhengping</searchLink><br /><searchLink fieldCode="AR" term="%22Roder%2C+John%22">Roder, John</searchLink><br /><searchLink fieldCode="AR" term="%22Bai%2C+Donglin%22">Bai, Donglin</searchLink><br /><searchLink fieldCode="AR" term="%22Orser%2C+Beverley+A%2E%22">Orser, Beverley A.</searchLink><br /><searchLink fieldCode="AR" term="%22MacDonald%2C+John+F%2E%22">MacDonald, John F.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Jun2000, Vol. 3 Issue 6, p559. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Protein+kinases%22">Protein kinases</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+transmission%22">Neural transmission</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: In central neurons, the second messenger cGMP is believed to induce long-term changes in efficacy at glutamatergic synapses through activation of protein kinase G (PKG). Stimulating nitric oxide synthase, activating soluble guanylyl cyclase or elevating concentrations of intracellular cGMP depressed excitatory synaptic transmission in CA1 hippocampal neurons. Unexpectedly, intracellular cGMP depressed responses of AMPA receptors and inhibited excitatory postsynaptic currents in hippocampal neurons independently of phosphorylation. Our findings demonstrate that cGMP's modulation of excitatory transmission may involve a coupling of AMPA channel activity to levels of cGMP. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/75729 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 559 Subjects: – SubjectFull: Protein kinases Type: general – SubjectFull: Neural transmission Type: general Titles: – TitleFull: Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lei, Saobo – PersonEntity: Name: NameFull: Jackson, Michael F. – PersonEntity: Name: NameFull: Jia, Zhengping – PersonEntity: Name: NameFull: Roder, John – PersonEntity: Name: NameFull: Bai, Donglin – PersonEntity: Name: NameFull: Orser, Beverley A. – PersonEntity: Name: NameFull: MacDonald, John F. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2000 Type: published Y: 2000 Identifiers: – Type: issn-print Value: 10976256 Numbering: – Type: volume Value: 3 – Type: issue Value: 6 Titles: – TitleFull: Nature Neuroscience Type: main |
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