PLC-β1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex.
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| Title: | PLC-β1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex. |
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| Authors: | Hannan, Anthony J., Blakemore, Colin, Katsnelson, Alla, Vitalis, Tania, Huber, Kimberly M., Bear, Mark, Roder, John, Kim, Daesoo, Shin, Hee-Sup, Kind, Peter C. |
| Source: | Nature Neuroscience. Mar2001, Vol. 4 Issue 3, p282. 7p. |
| Subjects: | Cerebral cortex, Axons, Neural transmission |
| Abstract: | During development of the cerebral cortex, the invasion of thalamic axons and subsequent differentiation of cortical neurons are tightly coordinated. Here we provide evidence that glutamate neurotransmission triggers a critical signaling mechanism involving the activation of phospholipase C-β1 (PLC-β1) by metabotropic glutamate receptors (mGluRs). Homozygous null mutation of either PLC-β1 or mGluR5 dramatically disrupts the cytoarchitectural differentiation of 'barrels' in the mouse somatosensory cortex, despite segregation in the pattern of thalamic innervation. Furthermore, group 1 mGluR-stimulated phosphoinositide hydrolysis is dramatically reduced in PLC-β1[sup -/-] mice during barrel development. Our data indicate that PLC-β1 activation via mGluR5 is critical for the coordinated development of the neocortex, and that presynaptic and postsynaptic components of cortical differentiation can be genetically dissociated. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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