Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity.
Saved in:
| Title: | Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity. |
|---|---|
| Authors: | Hardingham, Giles E., Arnold, Fiona J. L., Bading, Hilmar |
| Source: | Nature Neuroscience. Mar2001, Vol. 4 Issue 3, p261. 7p. |
| Subjects: | Calcium, Nervous system, Synapses, Gene expression |
| Abstract: | Information storage in the nervous system requires transcription triggered by synaptically evoked calcium signals. It has been suggested that translocation of calmodulin into the nucleus, initiated by submembranous calcium transients, relays synaptic signals to CREB. Here we show that in hippocampal neurons, signaling to CREB can be activated by nuclear calcium alone and does not require import of cytoplasmic proteins into the nucleus. The nucleus is particularly suited to integrate neuronal firing patterns, and specifies the transcriptional outputs through a burst frequency-tonuclear calcium amplitude conversion. Calcium release from intracellular stores promotes calcium wave propagation into the nucleus, which is critical for CREB-mediated transcription by synaptic NMDA receptors. Pharmacological or genetic modulation of nuclear calcium may directly affect transcription-dependent memory and cognitive functions. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 8829726 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hardingham%2C+Giles+E%2E%22">Hardingham, Giles E.</searchLink><br /><searchLink fieldCode="AR" term="%22Arnold%2C+Fiona+J%2E+L%2E%22">Arnold, Fiona J. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Bading%2C+Hilmar%22">Bading, Hilmar</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Mar2001, Vol. 4 Issue 3, p261. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Calcium%22">Calcium</searchLink><br /><searchLink fieldCode="DE" term="%22Nervous+system%22">Nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Synapses%22">Synapses</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Information storage in the nervous system requires transcription triggered by synaptically evoked calcium signals. It has been suggested that translocation of calmodulin into the nucleus, initiated by submembranous calcium transients, relays synaptic signals to CREB. Here we show that in hippocampal neurons, signaling to CREB can be activated by nuclear calcium alone and does not require import of cytoplasmic proteins into the nucleus. The nucleus is particularly suited to integrate neuronal firing patterns, and specifies the transcriptional outputs through a burst frequency-tonuclear calcium amplitude conversion. Calcium release from intracellular stores promotes calcium wave propagation into the nucleus, which is critical for CREB-mediated transcription by synaptic NMDA receptors. Pharmacological or genetic modulation of nuclear calcium may directly affect transcription-dependent memory and cognitive functions. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=8829726 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/85109 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 261 Subjects: – SubjectFull: Calcium Type: general – SubjectFull: Nervous system Type: general – SubjectFull: Synapses Type: general – SubjectFull: Gene expression Type: general Titles: – TitleFull: Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hardingham, Giles E. – PersonEntity: Name: NameFull: Arnold, Fiona J. L. – PersonEntity: Name: NameFull: Bading, Hilmar IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2001 Type: published Y: 2001 Identifiers: – Type: issn-print Value: 10976256 Numbering: – Type: volume Value: 4 – Type: issue Value: 3 Titles: – TitleFull: Nature Neuroscience Type: main |
| ResultId | 1 |
