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A search for specific and common susceptibility loci for schizophrenia and bipolar disorder: a linkage study in 13 target chromosomes.

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Title: A search for specific and common susceptibility loci for schizophrenia and bipolar disorder: a linkage study in 13 target chromosomes.
Authors: Maziade, M, Roy, M-A, Rouillard, É, Bissonnette, L, Fournier, J-P, Roy, A, Garneau, Y, Montgrain, N, Potvin, A, Cliche, D, Dion, C, Wallot, H, Fournier, A, Nicole, L, Lavallée, J-C, Mérette, C
Source: Molecular Psychiatry. 2001, Vol. 6 Issue 6, p684. 10p.
Subjects: Schizophrenia, Mental illness, Linkage (Genetics)
Abstract: We report the first stage of a genome scan of schizophrenia (SZ) and bipolar disorder (BP) covering 18 candidate chromosomal areas. In addition to testing susceptibility loci that are specific to each disorder, we tested the hypothesis that some susceptibility loci might be common to both disorders. A total of 480 individuals from 21 multigenerational pedigrees of Eastern Que&ecute; were evaluated by means of a consensus best-estimate diagnosis made blind to diagnoses in relatives and were genotyped with 220 microsatellite markers. Two-point and multipoint model-based linkage analyses were performed and mod scores (Z, for max Z[SUBmax]) are reported. The strongest linkage signals were detected at D18S1145 (in 18q12; Z = 4.03) for BP, and at D6S334 (in 6p 22-24; Z[SUBhet] = 3.47; α = 0.66) for SZ. Three other chromosomal areas (3q, 10p, and 21q) yielded linkage signals. Chromosomes 3p, 4p, 5p, 5q, 6q, 8p, 9q, 11q, 11p, 12q, 13q, 18p and 22q showed no evidence of linkage. The 18q12 results met the Lander and Kruglyak (1995) criterion for a genome-wide significant linkage and suggested that this susceptibility region may be shared by SZ and BP. The 6p finding provided confirmatory evidence of linkage for SZ. Our results suggest that both specific and common susceptibility loci must be searched for SZ and BP. [ABSTRACT FROM AUTHOR]
Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: A search for specific and common susceptibility loci for schizophrenia and bipolar disorder: a linkage study in 13 target chromosomes.
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  Data: <searchLink fieldCode="AR" term="%22Maziade%2C+M%22">Maziade, M</searchLink><br /><searchLink fieldCode="AR" term="%22Roy%2C+M-A%22">Roy, M-A</searchLink><br /><searchLink fieldCode="AR" term="%22Rouillard%2C+É%22">Rouillard, É</searchLink><br /><searchLink fieldCode="AR" term="%22Bissonnette%2C+L%22">Bissonnette, L</searchLink><br /><searchLink fieldCode="AR" term="%22Fournier%2C+J-P%22">Fournier, J-P</searchLink><br /><searchLink fieldCode="AR" term="%22Roy%2C+A%22">Roy, A</searchLink><br /><searchLink fieldCode="AR" term="%22Garneau%2C+Y%22">Garneau, Y</searchLink><br /><searchLink fieldCode="AR" term="%22Montgrain%2C+N%22">Montgrain, N</searchLink><br /><searchLink fieldCode="AR" term="%22Potvin%2C+A%22">Potvin, A</searchLink><br /><searchLink fieldCode="AR" term="%22Cliche%2C+D%22">Cliche, D</searchLink><br /><searchLink fieldCode="AR" term="%22Dion%2C+C%22">Dion, C</searchLink><br /><searchLink fieldCode="AR" term="%22Wallot%2C+H%22">Wallot, H</searchLink><br /><searchLink fieldCode="AR" term="%22Fournier%2C+A%22">Fournier, A</searchLink><br /><searchLink fieldCode="AR" term="%22Nicole%2C+L%22">Nicole, L</searchLink><br /><searchLink fieldCode="AR" term="%22Lavallée%2C+J-C%22">Lavallée, J-C</searchLink><br /><searchLink fieldCode="AR" term="%22Mérette%2C+C%22">Mérette, C</searchLink>
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  Data: We report the first stage of a genome scan of schizophrenia (SZ) and bipolar disorder (BP) covering 18 candidate chromosomal areas. In addition to testing susceptibility loci that are specific to each disorder, we tested the hypothesis that some susceptibility loci might be common to both disorders. A total of 480 individuals from 21 multigenerational pedigrees of Eastern Que&ecute; were evaluated by means of a consensus best-estimate diagnosis made blind to diagnoses in relatives and were genotyped with 220 microsatellite markers. Two-point and multipoint model-based linkage analyses were performed and mod scores (Z, for max Z[SUBmax]) are reported. The strongest linkage signals were detected at D18S1145 (in 18q12; Z = 4.03) for BP, and at D6S334 (in 6p 22-24; Z[SUBhet] = 3.47; α = 0.66) for SZ. Three other chromosomal areas (3q, 10p, and 21q) yielded linkage signals. Chromosomes 3p, 4p, 5p, 5q, 6q, 8p, 9q, 11q, 11p, 12q, 13q, 18p and 22q showed no evidence of linkage. The 18q12 results met the Lander and Kruglyak (1995) criterion for a genome-wide significant linkage and suggested that this susceptibility region may be shared by SZ and BP. The 6p finding provided confirmatory evidence of linkage for SZ. Our results suggest that both specific and common susceptibility loci must be searched for SZ and BP. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Linkage (Genetics)
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