Beta-blockers may reduce intrusive thoughts in newly diagnosed cancer patients.
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| Title: | Beta-blockers may reduce intrusive thoughts in newly diagnosed cancer patients. |
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| Authors: | Lindgren, Monica E., Fagundes, Christopher P., Alfano, Catherine M., Povoski, Stephen P., Agnese, Doreen M., Arnold, Mark W., Farrar, William B., Yee, Lisa D., Carson, William E., Schmidt, Carl R., Kiecolt‐Glaser, Janice K. |
| Source: | Psycho-Oncology. Aug2013, Vol. 22 Issue 8, p1889-1894. 6p. 3 Charts. |
| Subjects: | Breast cancer surgery, Cancer patients, Depressed persons, Flashbacks (Memory), Mental depression, Neurasthenia, Arousal (Physiology), Psychology |
| Abstract: | Objective A cancer diagnosis provokes significant levels of emotional distress, with intrusive thoughts being the most common manifestation among breast cancer survivors. Cancer-related intrusive thoughts can take the form of emotional memories, flashbacks, nightmares, and intrusive images. Emotional arousal after a severe life stressor prolongs adrenergic activation, which in turn may increase risk for post-traumatic symptomatology. However, antihypertensive beta-blockers block adrenergic activation and are known to reduce traumatic memories and related psychological distress. Thus, the current study examined the association between beta-blocker use and the severity of cancer-related intrusive thoughts and related symptoms following a cancer diagnosis. Methods The 174 breast and 36 female colorectal cancer patients who had recently undergone diagnostic screening or biopsy included 39 beta-blocker users and 171 non-users. Prior to any cancer treatment including surgery, participants completed questionnaires that included the Impact of Events Scale and the Center for Epidemiological Studies Depression Scale. Analyses controlled for age, education, cancer stage, cancer type, days since diagnosis, marital status, depression, and comorbidities. Results Although the high rates of cancer-related distress in this sample were similar to those of other studies with recently diagnosed patients, beta-blocker users endorsed 32% fewer cancer-related intrusive thoughts than non-users. Conclusions Recently diagnosed cancer patients using beta-blockers reported less cancer-related psychological distress. These results suggest that beta-blocker use may benefit cancer patients' psychological adjustment following diagnosis, and provide a promising direction for future investigations on the pharmacological benefits of beta-blockers for cancer-related distress. Copyright © 2012 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
| Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 89220369 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Beta-blockers may reduce intrusive thoughts in newly diagnosed cancer patients. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lindgren%2C+Monica+E%2E%22">Lindgren, Monica E.</searchLink><br /><searchLink fieldCode="AR" term="%22Fagundes%2C+Christopher+P%2E%22">Fagundes, Christopher P.</searchLink><br /><searchLink fieldCode="AR" term="%22Alfano%2C+Catherine+M%2E%22">Alfano, Catherine M.</searchLink><br /><searchLink fieldCode="AR" term="%22Povoski%2C+Stephen+P%2E%22">Povoski, Stephen P.</searchLink><br /><searchLink fieldCode="AR" term="%22Agnese%2C+Doreen+M%2E%22">Agnese, Doreen M.</searchLink><br /><searchLink fieldCode="AR" term="%22Arnold%2C+Mark+W%2E%22">Arnold, Mark W.</searchLink><br /><searchLink fieldCode="AR" term="%22Farrar%2C+William+B%2E%22">Farrar, William B.</searchLink><br /><searchLink fieldCode="AR" term="%22Yee%2C+Lisa+D%2E%22">Yee, Lisa D.</searchLink><br /><searchLink fieldCode="AR" term="%22Carson%2C+William+E%2E%22">Carson, William E.</searchLink><br /><searchLink fieldCode="AR" term="%22Schmidt%2C+Carl+R%2E%22">Schmidt, Carl R.</searchLink><br /><searchLink fieldCode="AR" term="%22Kiecolt‐Glaser%2C+Janice+K%2E%22">Kiecolt‐Glaser, Janice K.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psycho-Oncology%22">Psycho-Oncology</searchLink>. Aug2013, Vol. 22 Issue 8, p1889-1894. 6p. 3 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Breast+cancer+surgery%22">Breast cancer surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+patients%22">Cancer patients</searchLink><br /><searchLink fieldCode="DE" term="%22Depressed+persons%22">Depressed persons</searchLink><br /><searchLink fieldCode="DE" term="%22Flashbacks+%28Memory%29%22">Flashbacks (Memory)</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Neurasthenia%22">Neurasthenia</searchLink><br /><searchLink fieldCode="DE" term="%22Arousal+%28Physiology%29%22">Arousal (Physiology)</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology%22">Psychology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective A cancer diagnosis provokes significant levels of emotional distress, with intrusive thoughts being the most common manifestation among breast cancer survivors. Cancer-related intrusive thoughts can take the form of emotional memories, flashbacks, nightmares, and intrusive images. Emotional arousal after a severe life stressor prolongs adrenergic activation, which in turn may increase risk for post-traumatic symptomatology. However, antihypertensive beta-blockers block adrenergic activation and are known to reduce traumatic memories and related psychological distress. Thus, the current study examined the association between beta-blocker use and the severity of cancer-related intrusive thoughts and related symptoms following a cancer diagnosis. Methods The 174 breast and 36 female colorectal cancer patients who had recently undergone diagnostic screening or biopsy included 39 beta-blocker users and 171 non-users. Prior to any cancer treatment including surgery, participants completed questionnaires that included the Impact of Events Scale and the Center for Epidemiological Studies Depression Scale. Analyses controlled for age, education, cancer stage, cancer type, days since diagnosis, marital status, depression, and comorbidities. Results Although the high rates of cancer-related distress in this sample were similar to those of other studies with recently diagnosed patients, beta-blocker users endorsed 32% fewer cancer-related intrusive thoughts than non-users. Conclusions Recently diagnosed cancer patients using beta-blockers reported less cancer-related psychological distress. These results suggest that beta-blocker use may benefit cancer patients' psychological adjustment following diagnosis, and provide a promising direction for future investigations on the pharmacological benefits of beta-blockers for cancer-related distress. Copyright © 2012 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/pon.3233 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 1889 Subjects: – SubjectFull: Breast cancer surgery Type: general – SubjectFull: Cancer patients Type: general – SubjectFull: Depressed persons Type: general – SubjectFull: Flashbacks (Memory) Type: general – SubjectFull: Mental depression Type: general – SubjectFull: Neurasthenia Type: general – SubjectFull: Arousal (Physiology) Type: general – SubjectFull: Psychology Type: general Titles: – TitleFull: Beta-blockers may reduce intrusive thoughts in newly diagnosed cancer patients. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lindgren, Monica E. – PersonEntity: Name: NameFull: Fagundes, Christopher P. – PersonEntity: Name: NameFull: Alfano, Catherine M. – PersonEntity: Name: NameFull: Povoski, Stephen P. – PersonEntity: Name: NameFull: Agnese, Doreen M. – PersonEntity: Name: NameFull: Arnold, Mark W. – PersonEntity: Name: NameFull: Farrar, William B. – PersonEntity: Name: NameFull: Yee, Lisa D. – PersonEntity: Name: NameFull: Carson, William E. – PersonEntity: Name: NameFull: Schmidt, Carl R. – PersonEntity: Name: NameFull: Kiecolt‐Glaser, Janice K. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 10579249 Numbering: – Type: volume Value: 22 – Type: issue Value: 8 Titles: – TitleFull: Psycho-Oncology Type: main |
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