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Temporal Sequence Learning in Healthy Aging and Amnestic Mild Cognitive Impairment.

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Title: Temporal Sequence Learning in Healthy Aging and Amnestic Mild Cognitive Impairment.
Authors: Pirogovsky, Eva (AUTHOR), Holden, HeatherM. (AUTHOR), Jenkins, Cecily (AUTHOR), Peavy, GuerryM. (AUTHOR), Salmon, DavidP. (AUTHOR), Galasko, DouglasR. (AUTHOR), Gilbert, PaulE. (AUTHOR)
Source: Experimental Aging Research. Jul-Sep2013, Vol. 39 Issue 4, p371-381. 11p.
Subjects: Aging, Analysis of variance, Cognition disorders, Comparative studies, Computer-aided design, Experimental design, Learning, Memory, Psychological tests, Research funding, Temporal lobe, Time, Control groups, Repeated measures design, Geriatric Depression Scale, Descriptive statistics
Geographic Terms: California
Abstract: Background/Study Context: Temporal sequence learning is a critical aspect of episodic memory that may be dependent on the temporal and frontal lobes. Because amnestic mild cognitive impairment (aMCI) and normal aging may result in changes within the temporal and frontal lobes, the present study investigated temporal sequence learning in patients with aMCI, cognitively normal older adults, and young adults. Methods: On each trial of a temporal sequence task, circles appeared one at a time at the end of each arm of a computerized radial eight-arm maze. Participants were asked to reproduce the temporal sequence by placing numbered circles (1 to 8) on the arms of the eight-arm maze. Participants were presented with the same fixed sequence on each trial until the sequence was replicated without any errors, or until 15 trials were presented. Results: Individuals with aMCI required significantly more trials to learn the temporal sequence compared with older adults (p < .05). Older adults required significantly more trials to learn the sequence than young adults (p < .05). Older adults and individuals with aMCI committed significantly more Trial 1 errors (p < .05) than young adults; however, there were no significant differences between the aMCI and older adult groups on Trial 1. Conclusion: The results suggest that temporal sequence learning deficits are detectable in aMCI. These deficits may disrupt a number of cognitive processes, such as episodic memory, that are important for the execution of daily activities. The results suggest that although temporal sequence learning declines with normal aging, this decline is greater in individuals who have a diagnosis of aMCI and are at higher risk for developing Alzheimer's disease. [ABSTRACT FROM PUBLISHER]
Copyright of Experimental Aging Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Temporal Sequence Learning in Healthy Aging and Amnestic Mild Cognitive Impairment.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pirogovsky%2C+Eva%22&quot;&gt;Pirogovsky, Eva&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Holden%2C+HeatherM%2E%22&quot;&gt;Holden, HeatherM.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jenkins%2C+Cecily%22&quot;&gt;Jenkins, Cecily&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Peavy%2C+GuerryM%2E%22&quot;&gt;Peavy, GuerryM.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Salmon%2C+DavidP%2E%22&quot;&gt;Salmon, DavidP.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Galasko%2C+DouglasR%2E%22&quot;&gt;Galasko, DouglasR.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gilbert%2C+PaulE%2E%22&quot;&gt;Gilbert, PaulE.&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Experimental+Aging+Research%22&quot;&gt;Experimental Aging Research&lt;/searchLink&gt;. Jul-Sep2013, Vol. 39 Issue 4, p371-381. 11p.
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  Data: Background/Study Context: Temporal sequence learning is a critical aspect of episodic memory that may be dependent on the temporal and frontal lobes. Because amnestic mild cognitive impairment (aMCI) and normal aging may result in changes within the temporal and frontal lobes, the present study investigated temporal sequence learning in patients with aMCI, cognitively normal older adults, and young adults. Methods: On each trial of a temporal sequence task, circles appeared one at a time at the end of each arm of a computerized radial eight-arm maze. Participants were asked to reproduce the temporal sequence by placing numbered circles (1 to 8) on the arms of the eight-arm maze. Participants were presented with the same fixed sequence on each trial until the sequence was replicated without any errors, or until 15 trials were presented. Results: Individuals with aMCI required significantly more trials to learn the temporal sequence compared with older adults (p&#160;&lt;&#160;.05). Older adults required significantly more trials to learn the sequence than young adults (p&#160;&lt;&#160;.05). Older adults and individuals with aMCI committed significantly more Trial 1 errors (p&#160;&lt;&#160;.05) than young adults; however, there were no significant differences between the aMCI and older adult groups on Trial 1. Conclusion: The results suggest that temporal sequence learning deficits are detectable in aMCI. These deficits may disrupt a number of cognitive processes, such as episodic memory, that are important for the execution of daily activities. The results suggest that although temporal sequence learning declines with normal aging, this decline is greater in individuals who have a diagnosis of aMCI and are at higher risk for developing Alzheimer&#39;s disease. [ABSTRACT FROM PUBLISHER]
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  Data: &lt;i&gt;Copyright of Experimental Aging Research is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/0361073X.2013.808122
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 371
    Subjects:
      – SubjectFull: Aging
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Cognition disorders
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Computer-aided design
        Type: general
      – SubjectFull: Experimental design
        Type: general
      – SubjectFull: Learning
        Type: general
      – SubjectFull: Memory
        Type: general
      – SubjectFull: Psychological tests
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Temporal lobe
        Type: general
      – SubjectFull: Time
        Type: general
      – SubjectFull: Control groups
        Type: general
      – SubjectFull: Repeated measures design
        Type: general
      – SubjectFull: Geriatric Depression Scale
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: California
        Type: general
    Titles:
      – TitleFull: Temporal Sequence Learning in Healthy Aging and Amnestic Mild Cognitive Impairment.
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            – D: 01
              M: 07
              Text: Jul-Sep2013
              Type: published
              Y: 2013
          Identifiers:
            – Type: issn-print
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            – TitleFull: Experimental Aging Research
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