NICOTINIC CHOLINERGIC RECEPTOR EXPRESSION IN THE HUMAN NASAL MUCOSA.
Saved in:
| Title: | NICOTINIC CHOLINERGIC RECEPTOR EXPRESSION IN THE HUMAN NASAL MUCOSA. |
|---|---|
| Authors: | Keiger, C. Jane H., Jones, Kim R., Case, L. Douglas, Drake, Amelia F., Kendal-Reed, Martin, Walker, James C. |
| Source: | Annals of Otology, Rhinology & Laryngology. Jan2003, Vol. 112 Issue 1, p77. 8p. |
| Subjects: | Nasal mucosa, Acetylcholine, Nicotine |
| Abstract: | Twenty-four nasal mucosa specimens were obtained from the inferior or middle turbinates of 6 normal subjects and 18 patients with chronic sinusitis, inflammatory polyp formation, or sinus allergies. Reverse transcription-polymerase chain reaction analysis was used to identify the non-neuronal nicotinic cholinergic receptor (nAChR) subunits that were expressed in the nasal mucosa. Collectively, transcripts for α (αl, α2, α3, α4, α6, α7) and β (β2, β3, β4) nAChR subunit genes were detected in the respiratory mucosa. The α3, α7, and β2 subunits were expressed in 92%, 88%, and 75% of the subjects, respectively. There was a high degree of interindividual variation in nAChR subunit gene expression among subjects. A significant univariate association was found between tissue type and β4 expression and between gender and β3 expression. These data suggest that cells in the nasal mucosa express the necessary messenger RNAs (mRNAs) for numerous nAChR combinations. Moreover, our identification of nAChR subunit mRNAs in the nasal mucosa extends the findings of other functional studies of nAChRs in nasal epithelial cells and implies that nicotine from tobacco products such as cigarette smoke and nicotine nasal spray may have direct cellular effects on nasal mucosa cells through activation of homogeneous or heterogeneous nAChRs. A significant number of patients receiving nicotine nasal spray have reported nasal irritation, and there are reports of transient irritation of the throat and trachea with the use of smoke-free nicotine cigarettes. These adverse respiratory effects may be due to activation of nAChRs in epithelial cells of the nose and trachea. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 8938523 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: NICOTINIC CHOLINERGIC RECEPTOR EXPRESSION IN THE HUMAN NASAL MUCOSA. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Keiger%2C+C%2E+Jane+H%2E%22">Keiger, C. Jane H.</searchLink><br /><searchLink fieldCode="AR" term="%22Jones%2C+Kim+R%2E%22">Jones, Kim R.</searchLink><br /><searchLink fieldCode="AR" term="%22Case%2C+L%2E+Douglas%22">Case, L. Douglas</searchLink><br /><searchLink fieldCode="AR" term="%22Drake%2C+Amelia+F%2E%22">Drake, Amelia F.</searchLink><br /><searchLink fieldCode="AR" term="%22Kendal-Reed%2C+Martin%22">Kendal-Reed, Martin</searchLink><br /><searchLink fieldCode="AR" term="%22Walker%2C+James+C%2E%22">Walker, James C.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Otology%2C+Rhinology+%26+Laryngology%22">Annals of Otology, Rhinology & Laryngology</searchLink>. Jan2003, Vol. 112 Issue 1, p77. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Nasal+mucosa%22">Nasal mucosa</searchLink><br /><searchLink fieldCode="DE" term="%22Acetylcholine%22">Acetylcholine</searchLink><br /><searchLink fieldCode="DE" term="%22Nicotine%22">Nicotine</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Twenty-four nasal mucosa specimens were obtained from the inferior or middle turbinates of 6 normal subjects and 18 patients with chronic sinusitis, inflammatory polyp formation, or sinus allergies. Reverse transcription-polymerase chain reaction analysis was used to identify the non-neuronal nicotinic cholinergic receptor (nAChR) subunits that were expressed in the nasal mucosa. Collectively, transcripts for α (αl, α2, α3, α4, α6, α7) and β (β2, β3, β4) nAChR subunit genes were detected in the respiratory mucosa. The α3, α7, and β2 subunits were expressed in 92%, 88%, and 75% of the subjects, respectively. There was a high degree of interindividual variation in nAChR subunit gene expression among subjects. A significant univariate association was found between tissue type and β4 expression and between gender and β3 expression. These data suggest that cells in the nasal mucosa express the necessary messenger RNAs (mRNAs) for numerous nAChR combinations. Moreover, our identification of nAChR subunit mRNAs in the nasal mucosa extends the findings of other functional studies of nAChRs in nasal epithelial cells and implies that nicotine from tobacco products such as cigarette smoke and nicotine nasal spray may have direct cellular effects on nasal mucosa cells through activation of homogeneous or heterogeneous nAChRs. A significant number of patients receiving nicotine nasal spray have reported nasal irritation, and there are reports of transient irritation of the throat and trachea with the use of smoke-free nicotine cigarettes. These adverse respiratory effects may be due to activation of nAChRs in epithelial cells of the nose and trachea. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=8938523 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1177/000348940311200115 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 77 Subjects: – SubjectFull: Nasal mucosa Type: general – SubjectFull: Acetylcholine Type: general – SubjectFull: Nicotine Type: general Titles: – TitleFull: NICOTINIC CHOLINERGIC RECEPTOR EXPRESSION IN THE HUMAN NASAL MUCOSA. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Keiger, C. Jane H. – PersonEntity: Name: NameFull: Jones, Kim R. – PersonEntity: Name: NameFull: Case, L. Douglas – PersonEntity: Name: NameFull: Drake, Amelia F. – PersonEntity: Name: NameFull: Kendal-Reed, Martin – PersonEntity: Name: NameFull: Walker, James C. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2003 Type: published Y: 2003 Identifiers: – Type: issn-print Value: 00034894 Numbering: – Type: volume Value: 112 – Type: issue Value: 1 Titles: – TitleFull: Annals of Otology, Rhinology & Laryngology Type: main |
| ResultId | 1 |
