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Large CAG/CTG repeats are associated with childhood-onset schizophrenia.

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Title: Large CAG/CTG repeats are associated with childhood-onset schizophrenia.
Authors: Burgess, C.E., Lindblad, K., Sidransky, E., Yuan, Q.-P., Long, R.T., Breschel, T., Ross, C.A., McInnis, M., Lee, P., Ginns, E.I., Lenane, M., Kumra, S., Jacobsen, L., Rapoport, J.L., Schalling, M.
Source: Molecular Psychiatry. 1998, Vol. 3 Issue 4, p321. 7p.
Subjects: Nucleotide sequence, Schizophrenia, Neuropsychiatry
Abstract: Recent studies have shown an association between trinucleotide repeat expansions (TREs) and adult-onset schizophrenia (AOS). Childhood-onset schizophrenia (COS) is a severe variant of schizophrenia with onset of symptoms before age 12 years. We have used the repeat expansion detection (RED) method to investigate the occurrence of repeat expansions in a group of well-characterized COS patients as well as a set of clinically related childhood-onset psychosis cases labeled 'multidimensionally impaired' (MDI). The difference observed in the CAG/CTG RED product distribution between normal (n=44) and COS (n=36) samples was only marginally significant (P=0.036). However, male COS samples (n=20) had a significantly different RED product distribution compared to male controls (n=25, P=0.002) with longer RED products in COS. No such difference was seen in females (n[sub cont] = 19; n[sub cos] = 16; P=0.236). The difference remained significant between male COS (n=12) and male controls (n=24) when only Caucasian samples were used (P=0.003). Similarly, the RED product distribution in male MDI samples (n=18) was significantly different compared to male controls (P=0.018). Some of the detected TREs in all three populations (COS, MDI and control) correlated with expanded alleles found at the CTG18.1 locus on chromosome 18. In conclusion, we have found an association between TREs and COS. This association is specifically significant in the male population. Thus, the occurrence of an expanded trinucleotide repeat may contribute to the genetic risk of COS, possibly in combination with other factors. [ABSTRACT FROM AUTHOR]
Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Large CAG/CTG repeats are associated with childhood-onset schizophrenia.
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  Data: <searchLink fieldCode="AR" term="%22Burgess%2C+C%2EE%2E%22">Burgess, C.E.</searchLink><br /><searchLink fieldCode="AR" term="%22Lindblad%2C+K%2E%22">Lindblad, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Sidransky%2C+E%2E%22">Sidransky, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Yuan%2C+Q%2E-P%2E%22">Yuan, Q.-P.</searchLink><br /><searchLink fieldCode="AR" term="%22Long%2C+R%2ET%2E%22">Long, R.T.</searchLink><br /><searchLink fieldCode="AR" term="%22Breschel%2C+T%2E%22">Breschel, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Ross%2C+C%2EA%2E%22">Ross, C.A.</searchLink><br /><searchLink fieldCode="AR" term="%22McInnis%2C+M%2E%22">McInnis, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+P%2E%22">Lee, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Ginns%2C+E%2EI%2E%22">Ginns, E.I.</searchLink><br /><searchLink fieldCode="AR" term="%22Lenane%2C+M%2E%22">Lenane, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Kumra%2C+S%2E%22">Kumra, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Jacobsen%2C+L%2E%22">Jacobsen, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Rapoport%2C+J%2EL%2E%22">Rapoport, J.L.</searchLink><br /><searchLink fieldCode="AR" term="%22Schalling%2C+M%2E%22">Schalling, M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. 1998, Vol. 3 Issue 4, p321. 7p.
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  Data: Recent studies have shown an association between trinucleotide repeat expansions (TREs) and adult-onset schizophrenia (AOS). Childhood-onset schizophrenia (COS) is a severe variant of schizophrenia with onset of symptoms before age 12 years. We have used the repeat expansion detection (RED) method to investigate the occurrence of repeat expansions in a group of well-characterized COS patients as well as a set of clinically related childhood-onset psychosis cases labeled 'multidimensionally impaired' (MDI). The difference observed in the CAG/CTG RED product distribution between normal (n=44) and COS (n=36) samples was only marginally significant (P=0.036). However, male COS samples (n=20) had a significantly different RED product distribution compared to male controls (n=25, P=0.002) with longer RED products in COS. No such difference was seen in females (n[sub cont] = 19; n[sub cos] = 16; P=0.236). The difference remained significant between male COS (n=12) and male controls (n=24) when only Caucasian samples were used (P=0.003). Similarly, the RED product distribution in male MDI samples (n=18) was significantly different compared to male controls (P=0.018). Some of the detected TREs in all three populations (COS, MDI and control) correlated with expanded alleles found at the CTG18.1 locus on chromosome 18. In conclusion, we have found an association between TREs and COS. This association is specifically significant in the male population. Thus, the occurrence of an expanded trinucleotide repeat may contribute to the genetic risk of COS, possibly in combination with other factors. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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