Changes in adherence and treatment costs following initiation of oral or depot typical antipsychotics among previously non-adherent patients with schizophrenia.
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| Title: | Changes in adherence and treatment costs following initiation of oral or depot typical antipsychotics among previously non-adherent patients with schizophrenia. |
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| Authors: | Hong, Jihyung, Novick, Diego, Brugnoli, Roberto, Bertsch, Jordan, Haro, Josep Maria |
| Source: | Human Psychopharmacology: Clinical & Experimental. Sep2013, Vol. 28 Issue 5, p438-446. 9p. 4 Charts. |
| Subjects: | Antipsychotic agents, Schizophrenia, Psychiatrists, Psychoses, Logistic regression analysis |
| Abstract: | Objective This study assessed the impact of depot formulations on adherence and treating costs in the naturalistic treatment of previously non-adherent outpatients with schizophrenia. Methods Data were taken from the European Schizophrenia Outpatient Health Outcomes (SOHO) study. Medication adherence and treating costs during an 18-month follow-up were assessed and compared for non-adherent patients initiated on depot typical ( n = 262) or oral typical antipsychotics ( n = 169) as monotherapy at the index visit. Multivariate analyses were employed to adjust for differences between the two groups at the index visit. Results Of the previously non-adherent patients, more than half of patients initiated on depot typicals (55%) remained adherent to medication during follow-up, whereas the equivalent was 39% for patients initiated on oral typicals. Logistic regression also showed higher odds of being adherent among the former group (Odds ratio = 1.84; 95% CI = 1.19-2.85). In addition, total costs incurred by this group during 18 months were only half those incurred by patients initiated on oral typicals (£3645 vs £7817, p < 0.05) Conclusions Depot formulations of typical antipsychotics appeared to improve medication adherence and reduce treatment costs, compared with oral formulations, in the treatment of non-adherent patients. Limitation: adherence was assessed by the treating psychiatrist using a single-item. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
| Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 90133953 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Changes in adherence and treatment costs following initiation of oral or depot typical antipsychotics among previously non-adherent patients with schizophrenia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hong%2C+Jihyung%22">Hong, Jihyung</searchLink><br /><searchLink fieldCode="AR" term="%22Novick%2C+Diego%22">Novick, Diego</searchLink><br /><searchLink fieldCode="AR" term="%22Brugnoli%2C+Roberto%22">Brugnoli, Roberto</searchLink><br /><searchLink fieldCode="AR" term="%22Bertsch%2C+Jordan%22">Bertsch, Jordan</searchLink><br /><searchLink fieldCode="AR" term="%22Haro%2C+Josep+Maria%22">Haro, Josep Maria</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Human+Psychopharmacology%3A+Clinical+%26+Experimental%22">Human Psychopharmacology: Clinical & Experimental</searchLink>. Sep2013, Vol. 28 Issue 5, p438-446. 9p. 4 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Antipsychotic+agents%22">Antipsychotic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatrists%22">Psychiatrists</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective This study assessed the impact of depot formulations on adherence and treating costs in the naturalistic treatment of previously non-adherent outpatients with schizophrenia. Methods Data were taken from the European Schizophrenia Outpatient Health Outcomes (SOHO) study. Medication adherence and treating costs during an 18-month follow-up were assessed and compared for non-adherent patients initiated on depot typical ( n = 262) or oral typical antipsychotics ( n = 169) as monotherapy at the index visit. Multivariate analyses were employed to adjust for differences between the two groups at the index visit. Results Of the previously non-adherent patients, more than half of patients initiated on depot typicals (55%) remained adherent to medication during follow-up, whereas the equivalent was 39% for patients initiated on oral typicals. Logistic regression also showed higher odds of being adherent among the former group (Odds ratio = 1.84; 95% CI = 1.19-2.85). In addition, total costs incurred by this group during 18 months were only half those incurred by patients initiated on oral typicals (£3645 vs £7817, p < 0.05) Conclusions Depot formulations of typical antipsychotics appeared to improve medication adherence and reduce treatment costs, compared with oral formulations, in the treatment of non-adherent patients. Limitation: adherence was assessed by the treating psychiatrist using a single-item. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/hup.2328 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 438 Subjects: – SubjectFull: Antipsychotic agents Type: general – SubjectFull: Schizophrenia Type: general – SubjectFull: Psychiatrists Type: general – SubjectFull: Psychoses Type: general – SubjectFull: Logistic regression analysis Type: general Titles: – TitleFull: Changes in adherence and treatment costs following initiation of oral or depot typical antipsychotics among previously non-adherent patients with schizophrenia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hong, Jihyung – PersonEntity: Name: NameFull: Novick, Diego – PersonEntity: Name: NameFull: Brugnoli, Roberto – PersonEntity: Name: NameFull: Bertsch, Jordan – PersonEntity: Name: NameFull: Haro, Josep Maria IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 08856222 Numbering: – Type: volume Value: 28 – Type: issue Value: 5 Titles: – TitleFull: Human Psychopharmacology: Clinical & Experimental Type: main |
| ResultId | 1 |
