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Multiple sclerosis: association with the interleukin-1 gene family polymorphisms in the Turkish population.

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Title: Multiple sclerosis: association with the interleukin-1 gene family polymorphisms in the Turkish population.
Authors: Isik, Nihal (AUTHOR), Arman, Ahmet (AUTHOR), Canturk, Ilknur Aydın (AUTHOR), Gurkan, Ajda Coker (AUTHOR), Candan, Fatma (AUTHOR), Aktan, Sule (AUTHOR), Erzaim, Nilufer (AUTHOR), Duz, Ozge Arici (AUTHOR), Aydin, Tugrul (AUTHOR), Turkes, Muzaffer (AUTHOR), List, Edward O. (AUTHOR)
Source: International Journal of Neuroscience. Oct2013, Vol. 123 Issue 10, p711-718. 8p.
Abstract: Background: Multiple Sclerosis (MS) is a neurodegenerative disease. It involves inflammation and demyelination. Since cytokines play an important role in the development of MS, genes encoding cytokines such as the Interleukin (IL)-1 family are candidate genes for MS susceptibility. Objective: To determine the relationship between IL-1 gene family and MS in the Turkish population. Methods: A total of 409 MS patients and 256 healthy controls were included in the study. IL-1A -889 (rs 1800587), IL-1 RN variable number tandom repeat (VNTR), IL-1B -511 (rs 16944) and IL-1B +3953 (rs 1143634) polymorphisms were investigated from the genomic DNA, obtained via blood samples. Results: No association was found between IL-1A and IL-IRN polymorphisms and susceptibility to MS. However, we have found significantly decreased frequency of IL-1B -511 genotype (p = 0.004) in MS patients compared to controls. In addition, there was a significant association between IL-1B -511 (1/2) genotype and early onset MS (EOMS) (p = 0.0001). Conclusions: Individuals with the 2/2 genotype of IL-1B -511 have significantly decreased incidence of MS, suggesting a protective role for this genotype in the Turkish population. Additionally, IL-1B -511(1/2) genotype was determined as a possible risk factor for EOMS. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Multiple sclerosis: association with the interleukin-1 gene family polymorphisms in the Turkish population.
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  Data: <searchLink fieldCode="AR" term="%22Isik%2C+Nihal%22">Isik, Nihal</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arman%2C+Ahmet%22">Arman, Ahmet</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Canturk%2C+Ilknur+Aydın%22">Canturk, Ilknur Aydın</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gurkan%2C+Ajda+Coker%22">Gurkan, Ajda Coker</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Candan%2C+Fatma%22">Candan, Fatma</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aktan%2C+Sule%22">Aktan, Sule</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Erzaim%2C+Nilufer%22">Erzaim, Nilufer</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Duz%2C+Ozge+Arici%22">Duz, Ozge Arici</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aydin%2C+Tugrul%22">Aydin, Tugrul</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Turkes%2C+Muzaffer%22">Turkes, Muzaffer</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22List%2C+Edward+O%2E%22">List, Edward O.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Oct2013, Vol. 123 Issue 10, p711-718. 8p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Multiple Sclerosis (MS) is a neurodegenerative disease. It involves inflammation and demyelination. Since cytokines play an important role in the development of MS, genes encoding cytokines such as the Interleukin (IL)-1 family are candidate genes for MS susceptibility. Objective: To determine the relationship between IL-1 gene family and MS in the Turkish population. Methods: A total of 409 MS patients and 256 healthy controls were included in the study. IL-1A -889 (rs 1800587), IL-1 RN variable number tandom repeat (VNTR), IL-1B -511 (rs 16944) and IL-1B +3953 (rs 1143634) polymorphisms were investigated from the genomic DNA, obtained via blood samples. Results: No association was found between IL-1A and IL-IRN polymorphisms and susceptibility to MS. However, we have found significantly decreased frequency of IL-1B -511 genotype (p = 0.004) in MS patients compared to controls. In addition, there was a significant association between IL-1B -511 (1/2) genotype and early onset MS (EOMS) (p = 0.0001). Conclusions: Individuals with the 2/2 genotype of IL-1B -511 have significantly decreased incidence of MS, suggesting a protective role for this genotype in the Turkish population. Additionally, IL-1B -511(1/2) genotype was determined as a possible risk factor for EOMS. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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