Multiple sclerosis: association with the interleukin-1 gene family polymorphisms in the Turkish population.
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| Title: | Multiple sclerosis: association with the interleukin-1 gene family polymorphisms in the Turkish population. |
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| Authors: | Isik, Nihal (AUTHOR), Arman, Ahmet (AUTHOR), Canturk, Ilknur Aydın (AUTHOR), Gurkan, Ajda Coker (AUTHOR), Candan, Fatma (AUTHOR), Aktan, Sule (AUTHOR), Erzaim, Nilufer (AUTHOR), Duz, Ozge Arici (AUTHOR), Aydin, Tugrul (AUTHOR), Turkes, Muzaffer (AUTHOR), List, Edward O. (AUTHOR) |
| Source: | International Journal of Neuroscience. Oct2013, Vol. 123 Issue 10, p711-718. 8p. |
| Abstract: | Background: Multiple Sclerosis (MS) is a neurodegenerative disease. It involves inflammation and demyelination. Since cytokines play an important role in the development of MS, genes encoding cytokines such as the Interleukin (IL)-1 family are candidate genes for MS susceptibility. Objective: To determine the relationship between IL-1 gene family and MS in the Turkish population. Methods: A total of 409 MS patients and 256 healthy controls were included in the study. IL-1A -889 (rs 1800587), IL-1 RN variable number tandom repeat (VNTR), IL-1B -511 (rs 16944) and IL-1B +3953 (rs 1143634) polymorphisms were investigated from the genomic DNA, obtained via blood samples. Results: No association was found between IL-1A and IL-IRN polymorphisms and susceptibility to MS. However, we have found significantly decreased frequency of IL-1B -511 genotype (p = 0.004) in MS patients compared to controls. In addition, there was a significant association between IL-1B -511 (1/2) genotype and early onset MS (EOMS) (p = 0.0001). Conclusions: Individuals with the 2/2 genotype of IL-1B -511 have significantly decreased incidence of MS, suggesting a protective role for this genotype in the Turkish population. Additionally, IL-1B -511(1/2) genotype was determined as a possible risk factor for EOMS. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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