View in EDS HTML Full Text PDF Full Text

Epilepsy in individuals with neurofibromatosis type 1.

Saved in:
Bibliographic Details
Title: Epilepsy in individuals with neurofibromatosis type 1.
Authors: Ostendorf, Adam P., Gutmann, David H., Weisenberg, Judith L. Z.
Source: Epilepsia (Series 4). Oct2013, Vol. 54 Issue 10, p1810-1814. 5p.
Subjects: Epilepsy, Neurofibromatosis, Spasms, Medical records, Magnetic resonance imaging, Gliomas, Surgery
Abstract: Purpose To describe the clinical characteristics and outcomes of individuals with neurofibromatosis type 1 ( NF1) and seizures in the largest cohort reported to date. Methods A retrospective cross-sectional review of 536 individuals with NF1 was performed, and clinical data from 51 individuals with a history of at least one seizure were analyzed. Key Findings In individuals with NF1, 9.5% had a history of at least one unprovoked seizure, and 6.5% had documented epilepsy. Individuals with seizures were more likely to have inherited NF1 from their mother (p = 0.001). Focal seizures were the most common type, occurring in 57% of individuals, although generalized seizures, specific electroclinical syndromes, and the presence of multiple seizure types were also noted. Moreover, in 21% of individuals with a previously unremarkable magnetic resonance imaging ( MRI) study, neuroimaging at seizure onset revealed a new structural abnormality. In this population, 77% of individuals required multiple antiepileptic drugs ( AEDs), and some required epilepsy surgery, with the best results following temporal lobe glioma resection. Significance Compared to the general population, seizures are more common in individuals with NF1, where they are often focal and related to an intracranial neoplasm. These observations suggest that all individuals with NF1 and a new seizure should undergo MRI despite previous normal neuroimaging. Individuals with seizures and NF1 typically require more aggressive therapy than those without NF1 and should be considered for epilepsy surgery when appropriate. [ABSTRACT FROM AUTHOR]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 90525969
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Epilepsy in individuals with neurofibromatosis type 1.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Ostendorf%2C+Adam+P%2E%22">Ostendorf, Adam P.</searchLink><br /><searchLink fieldCode="AR" term="%22Gutmann%2C+David+H%2E%22">Gutmann, David H.</searchLink><br /><searchLink fieldCode="AR" term="%22Weisenberg%2C+Judith+L%2E+Z%2E%22">Weisenberg, Judith L. Z.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. Oct2013, Vol. 54 Issue 10, p1810-1814. 5p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Neurofibromatosis%22">Neurofibromatosis</searchLink><br /><searchLink fieldCode="DE" term="%22Spasms%22">Spasms</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+records%22">Medical records</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Gliomas%22">Gliomas</searchLink><br /><searchLink fieldCode="DE" term="%22Surgery%22">Surgery</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose To describe the clinical characteristics and outcomes of individuals with neurofibromatosis type 1 ( NF1) and seizures in the largest cohort reported to date. Methods A retrospective cross-sectional review of 536 individuals with NF1 was performed, and clinical data from 51 individuals with a history of at least one seizure were analyzed. Key Findings In individuals with NF1, 9.5% had a history of at least one unprovoked seizure, and 6.5% had documented epilepsy. Individuals with seizures were more likely to have inherited NF1 from their mother (p = 0.001). Focal seizures were the most common type, occurring in 57% of individuals, although generalized seizures, specific electroclinical syndromes, and the presence of multiple seizure types were also noted. Moreover, in 21% of individuals with a previously unremarkable magnetic resonance imaging ( MRI) study, neuroimaging at seizure onset revealed a new structural abnormality. In this population, 77% of individuals required multiple antiepileptic drugs ( AEDs), and some required epilepsy surgery, with the best results following temporal lobe glioma resection. Significance Compared to the general population, seizures are more common in individuals with NF1, where they are often focal and related to an intracranial neoplasm. These observations suggest that all individuals with NF1 and a new seizure should undergo MRI despite previous normal neuroimaging. Individuals with seizures and NF1 typically require more aggressive therapy than those without NF1 and should be considered for epilepsy surgery when appropriate. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=90525969
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/epi.12348
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 1810
    Subjects:
      – SubjectFull: Epilepsy
        Type: general
      – SubjectFull: Neurofibromatosis
        Type: general
      – SubjectFull: Spasms
        Type: general
      – SubjectFull: Medical records
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Gliomas
        Type: general
      – SubjectFull: Surgery
        Type: general
    Titles:
      – TitleFull: Epilepsy in individuals with neurofibromatosis type 1.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ostendorf, Adam P.
      – PersonEntity:
          Name:
            NameFull: Gutmann, David H.
      – PersonEntity:
          Name:
            NameFull: Weisenberg, Judith L. Z.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: Oct2013
              Type: published
              Y: 2013
          Identifiers:
            – Type: issn-print
              Value: 00139580
          Numbering:
            – Type: volume
              Value: 54
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: Epilepsia (Series 4)
              Type: main
ResultId 1