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Villification: How the Gut Gets Its Villi.

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Title: Villification: How the Gut Gets Its Villi.
Authors: Shyer, Amy E., Tallinen, Tuomas, Nerurkar, Nandan L., Zhiyan Wei, Gil, Eun Seok, Kaplan, David L., Tabin, Clifford J., Mahadevan, L.
Source: Science (pre-March 2025). 10/11/2013, Vol. 342 Issue 6155, preceding p212-218. 8p.
Subjects: Mesenchyme, Smooth muscle, Quantitative research, Intestinal development, Mathematical models, Villi (Anatomy), Epithelium
Abstract: The villi of the human and chick gut are formed in similar stepwise progressions, wherein the mesenchyme and attached epithelium first fold into longitudinal ridges, then a zigzag pattern, and lastly individual villi. We find that these steps of villification depend on the sequential differentiation of the distinct smooth muscle layers of the gut, which restrict the expansion of the growing endoderm and mesenchyme, generating compressive stresses that lead to their buckling and folding. A quantitative computationalmodel, incorporating measured properties of the developing gut, recapitulates the morphological patterns seen during villification in a variety of species. These results provide a mechanistic understanding of the formation of these elaborations of the lining of the gut, essential for providing sufficient surface area for nutrient absorption. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Data: Villification: How the Gut Gets Its Villi.
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  Data: <searchLink fieldCode="AR" term="%22Shyer%2C+Amy+E%2E%22">Shyer, Amy E.</searchLink><br /><searchLink fieldCode="AR" term="%22Tallinen%2C+Tuomas%22">Tallinen, Tuomas</searchLink><br /><searchLink fieldCode="AR" term="%22Nerurkar%2C+Nandan+L%2E%22">Nerurkar, Nandan L.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhiyan+Wei%22">Zhiyan Wei</searchLink><br /><searchLink fieldCode="AR" term="%22Gil%2C+Eun+Seok%22">Gil, Eun Seok</searchLink><br /><searchLink fieldCode="AR" term="%22Kaplan%2C+David+L%2E%22">Kaplan, David L.</searchLink><br /><searchLink fieldCode="AR" term="%22Tabin%2C+Clifford+J%2E%22">Tabin, Clifford J.</searchLink><br /><searchLink fieldCode="AR" term="%22Mahadevan%2C+L%2E%22">Mahadevan, L.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 10/11/2013, Vol. 342 Issue 6155, preceding p212-218. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Mesenchyme%22">Mesenchyme</searchLink><br /><searchLink fieldCode="DE" term="%22Smooth+muscle%22">Smooth muscle</searchLink><br /><searchLink fieldCode="DE" term="%22Quantitative+research%22">Quantitative research</searchLink><br /><searchLink fieldCode="DE" term="%22Intestinal+development%22">Intestinal development</searchLink><br /><searchLink fieldCode="DE" term="%22Mathematical+models%22">Mathematical models</searchLink><br /><searchLink fieldCode="DE" term="%22Villi+%28Anatomy%29%22">Villi (Anatomy)</searchLink><br /><searchLink fieldCode="DE" term="%22Epithelium%22">Epithelium</searchLink>
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  Data: The villi of the human and chick gut are formed in similar stepwise progressions, wherein the mesenchyme and attached epithelium first fold into longitudinal ridges, then a zigzag pattern, and lastly individual villi. We find that these steps of villification depend on the sequential differentiation of the distinct smooth muscle layers of the gut, which restrict the expansion of the growing endoderm and mesenchyme, generating compressive stresses that lead to their buckling and folding. A quantitative computationalmodel, incorporating measured properties of the developing gut, recapitulates the morphological patterns seen during villification in a variety of species. These results provide a mechanistic understanding of the formation of these elaborations of the lining of the gut, essential for providing sufficient surface area for nutrient absorption. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=90658794
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        Value: 10.1126/science.1238842
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        Text: English
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        PageCount: 8
        StartPage: 212
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      – SubjectFull: Mesenchyme
        Type: general
      – SubjectFull: Smooth muscle
        Type: general
      – SubjectFull: Quantitative research
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      – SubjectFull: Intestinal development
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      – SubjectFull: Mathematical models
        Type: general
      – SubjectFull: Villi (Anatomy)
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      – SubjectFull: Epithelium
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      – TitleFull: Villification: How the Gut Gets Its Villi.
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              Text: 10/11/2013
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              Y: 2013
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