View in EDS HTML Full Text PDF Full Text

Resting state synchrony in anxiety-related circuits of abstinent alcohol-dependent patients.

Saved in:
Bibliographic Details
Title: Resting state synchrony in anxiety-related circuits of abstinent alcohol-dependent patients.
Authors: Orban, Csaba (AUTHOR), McGonigle, John (AUTHOR), Kalk, Nicola J. (AUTHOR), Erritzoe, David (AUTHOR), Waldman, Adam D. (AUTHOR), Nutt, David J. (AUTHOR), Rabiner, Eugenii A. (AUTHOR), Lingford-Hughes, Anne R. (AUTHOR)
Source: American Journal of Drug & Alcohol Abuse. 2013, Vol. 39 Issue 6, p433-440. 8p.
Subjects: Anxiety, Neurobiology, Amygdaloid body, Brain physiology, Generalizability theory, Prefrontal cortex
Abstract: Background: Anxiety has been linked to initiation, maintenance and relapse of alcohol dependence. Neurobiological models of anxiety have proposed important roles for amygdala-insula and amygdala-medial prefrontal cortex interactions in the generation and regulation of anxiety states, respectively. Objectives: This study tested the hypotheses that abstinent alcohol-dependent patients would show a disruption of synchrony in these circuits as measured by resting state functional MRI. Methods: The study examined recently abstinent ( n = 13), longer-term abstinent ( n = 16) alcohol-dependent patients and healthy controls ( n = 22). Resting-state synchrony (RSS) was examined in specific circuits, where degree of synchrony has been found to correlate with state anxiety levels in previous studies. Results: Alcohol-dependent patients showed significantly elevated scores on anxiety and depression inventories compared with controls. No significant group differences in synchrony were observed between right amygdala and right ventromedial prefrontal cortex (vmPFC), between left amygdala and left vmPFC, or, after correction for multiple comparisons, right amygdala and dorsomedial prefrontal cortex (dmPFC). However, significantly decreased positive synchrony was found between left basolateral amygdala and left anterior insula, in patients relative to controls. Conclusion: Both early and longer-term abstinent alcohol-dependent patients showed increased anxiety levels relative to controls and altered resting state synchrony in circuits previously linked to state anxiety. Notably, the significant group differences in synchrony were in the opposite direction to our predictions based on the literature. These results may point to a lack of generalizability of models derived from young healthy homogeneous samples. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 91857836
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Resting state synchrony in anxiety-related circuits of abstinent alcohol-dependent patients.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Orban%2C+Csaba%22">Orban, Csaba</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McGonigle%2C+John%22">McGonigle, John</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kalk%2C+Nicola+J%2E%22">Kalk, Nicola J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Erritzoe%2C+David%22">Erritzoe, David</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Waldman%2C+Adam+D%2E%22">Waldman, Adam D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nutt%2C+David+J%2E%22">Nutt, David J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rabiner%2C+Eugenii+A%2E%22">Rabiner, Eugenii A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lingford-Hughes%2C+Anne+R%2E%22">Lingford-Hughes, Anne R.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Drug+%26+Alcohol+Abuse%22">American Journal of Drug & Alcohol Abuse</searchLink>. 2013, Vol. 39 Issue 6, p433-440. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Neurobiology%22">Neurobiology</searchLink><br /><searchLink fieldCode="DE" term="%22Amygdaloid+body%22">Amygdaloid body</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+physiology%22">Brain physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Generalizability+theory%22">Generalizability theory</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Anxiety has been linked to initiation, maintenance and relapse of alcohol dependence. Neurobiological models of anxiety have proposed important roles for amygdala-insula and amygdala-medial prefrontal cortex interactions in the generation and regulation of anxiety states, respectively. Objectives: This study tested the hypotheses that abstinent alcohol-dependent patients would show a disruption of synchrony in these circuits as measured by resting state functional MRI. Methods: The study examined recently abstinent ( n = 13), longer-term abstinent ( n = 16) alcohol-dependent patients and healthy controls ( n = 22). Resting-state synchrony (RSS) was examined in specific circuits, where degree of synchrony has been found to correlate with state anxiety levels in previous studies. Results: Alcohol-dependent patients showed significantly elevated scores on anxiety and depression inventories compared with controls. No significant group differences in synchrony were observed between right amygdala and right ventromedial prefrontal cortex (vmPFC), between left amygdala and left vmPFC, or, after correction for multiple comparisons, right amygdala and dorsomedial prefrontal cortex (dmPFC). However, significantly decreased positive synchrony was found between left basolateral amygdala and left anterior insula, in patients relative to controls. Conclusion: Both early and longer-term abstinent alcohol-dependent patients showed increased anxiety levels relative to controls and altered resting state synchrony in circuits previously linked to state anxiety. Notably, the significant group differences in synchrony were in the opposite direction to our predictions based on the literature. These results may point to a lack of generalizability of models derived from young healthy homogeneous samples. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=91857836
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3109/00952990.2013.846348
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 433
    Subjects:
      – SubjectFull: Anxiety
        Type: general
      – SubjectFull: Neurobiology
        Type: general
      – SubjectFull: Amygdaloid body
        Type: general
      – SubjectFull: Brain physiology
        Type: general
      – SubjectFull: Generalizability theory
        Type: general
      – SubjectFull: Prefrontal cortex
        Type: general
    Titles:
      – TitleFull: Resting state synchrony in anxiety-related circuits of abstinent alcohol-dependent patients.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Orban, Csaba
      – PersonEntity:
          Name:
            NameFull: McGonigle, John
      – PersonEntity:
          Name:
            NameFull: Kalk, Nicola J.
      – PersonEntity:
          Name:
            NameFull: Erritzoe, David
      – PersonEntity:
          Name:
            NameFull: Waldman, Adam D.
      – PersonEntity:
          Name:
            NameFull: Nutt, David J.
      – PersonEntity:
          Name:
            NameFull: Rabiner, Eugenii A.
      – PersonEntity:
          Name:
            NameFull: Lingford-Hughes, Anne R.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: 2013
              Type: published
              Y: 2013
          Identifiers:
            – Type: issn-print
              Value: 00952990
          Numbering:
            – Type: volume
              Value: 39
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: American Journal of Drug & Alcohol Abuse
              Type: main
ResultId 1