Cognitive Change in Older Women Using a Computerised Battery: A Longitudinal Quantitative Genetic Twin Study.
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| Title: | Cognitive Change in Older Women Using a Computerised Battery: A Longitudinal Quantitative Genetic Twin Study. |
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| Authors: | Steves, Claire J., Jackson, Stephen H. D., Spector, Tim D. |
| Source: | Behavior Genetics. Nov2013, Vol. 43 Issue 6, p468-479. 12p. |
| Subjects: | Age factors in cognition, Mental health of older women, Neuropsychological tests, Effect of environment on human beings, Heritability, Twins |
| Abstract: | Cognitive performance is known to change over age 45, especially processing speed. Studies to date indicate that change in performance with ageing is largely environmentally mediated, with little contribution from genetics. We estimated the heritability of a longitudinal battery of computerised cognitive tests including speed measures, using a classical twin design. 324 (127 MZ, 197 DZ) female twins, aged 43–73 at baseline testing, were followed-up after 10 years, using seven measures of the Cambridge Automated Neuropsychological Test battery, four of which were measures of response latency (speed). Results were analysed using univariate and bivariate structural equation modelling. Heritability of longitudinal change was found in 5 of the 7 tests, ranging from 21 to 41 %. The genetic aetiology was remarkably stable. The first principle component of change was strongly associated with age ( p < 0.001) and heritable at 47 % (27–62 %). While estimates for heritability increased in all measures over time compared to baseline, these increases were statistically non-significant. This computerised battery showed significant heritability of age-related change in cognition. Focus on this form of change may aid the search for genetic pathways involved in normal and pre-morbid cognitive ageing. [ABSTRACT FROM AUTHOR] |
| Copyright of Behavior Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 91897752 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Cognitive Change in Older Women Using a Computerised Battery: A Longitudinal Quantitative Genetic Twin Study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Steves%2C+Claire+J%2E%22">Steves, Claire J.</searchLink><br /><searchLink fieldCode="AR" term="%22Jackson%2C+Stephen+H%2E+D%2E%22">Jackson, Stephen H. D.</searchLink><br /><searchLink fieldCode="AR" term="%22Spector%2C+Tim+D%2E%22">Spector, Tim D.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Behavior+Genetics%22">Behavior Genetics</searchLink>. Nov2013, Vol. 43 Issue 6, p468-479. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Age+factors+in+cognition%22">Age factors in cognition</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health+of+older+women%22">Mental health of older women</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychological+tests%22">Neuropsychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Effect+of+environment+on+human+beings%22">Effect of environment on human beings</searchLink><br /><searchLink fieldCode="DE" term="%22Heritability%22">Heritability</searchLink><br /><searchLink fieldCode="DE" term="%22Twins%22">Twins</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Cognitive performance is known to change over age 45, especially processing speed. Studies to date indicate that change in performance with ageing is largely environmentally mediated, with little contribution from genetics. We estimated the heritability of a longitudinal battery of computerised cognitive tests including speed measures, using a classical twin design. 324 (127 MZ, 197 DZ) female twins, aged 43–73 at baseline testing, were followed-up after 10 years, using seven measures of the Cambridge Automated Neuropsychological Test battery, four of which were measures of response latency (speed). Results were analysed using univariate and bivariate structural equation modelling. Heritability of longitudinal change was found in 5 of the 7 tests, ranging from 21 to 41 %. The genetic aetiology was remarkably stable. The first principle component of change was strongly associated with age ( p < 0.001) and heritable at 47 % (27–62 %). While estimates for heritability increased in all measures over time compared to baseline, these increases were statistically non-significant. This computerised battery showed significant heritability of age-related change in cognition. Focus on this form of change may aid the search for genetic pathways involved in normal and pre-morbid cognitive ageing. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Behavior Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10519-013-9612-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 468 Subjects: – SubjectFull: Age factors in cognition Type: general – SubjectFull: Mental health of older women Type: general – SubjectFull: Neuropsychological tests Type: general – SubjectFull: Effect of environment on human beings Type: general – SubjectFull: Heritability Type: general – SubjectFull: Twins Type: general Titles: – TitleFull: Cognitive Change in Older Women Using a Computerised Battery: A Longitudinal Quantitative Genetic Twin Study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Steves, Claire J. – PersonEntity: Name: NameFull: Jackson, Stephen H. D. – PersonEntity: Name: NameFull: Spector, Tim D. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 00018244 Numbering: – Type: volume Value: 43 – Type: issue Value: 6 Titles: – TitleFull: Behavior Genetics Type: main |
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