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Local energy depletion in the basal forebrain increases sleep.

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Title: Local energy depletion in the basal forebrain increases sleep.
Authors: Kalinchuk, Anna V. (AUTHOR), Urrila, Anna‐Sofia (AUTHOR), Alanko, Lauri (AUTHOR), Heiskanen, Silja (AUTHOR), Wigren, Henna‐Kaisa (AUTHOR), Suomela, Maricel (AUTHOR), Stenberg, Dag (AUTHOR), Porkka‐Heiskanen, Tarja (AUTHOR)
Source: European Journal of Neuroscience. Feb2003, Vol. 17 Issue 4, p863-869. 0p.
Subjects: Basal ganglia, Sleep, Dinitrophenol, Energy metabolism
Abstract: Abstract Sleep saves energy, but can brain energy depletion induce sleep? We used 2,4-dinitrophenol (DNP), a molecule which prevents the synthesis of ATP, to induce local energy depletion in the basal forebrain of rats. Three-hour DNP infusions induced elevations in extracellular concentrations of lactate, pyruvate and adenosine, as well as increases in non-REM sleep during the following night. Sleep was not affected when DNP was administered to adjacent brain areas, although the metabolic changes were similar. The amount and the timing of the increase in non-REM sleep, as well as in the concentrations of lactate, pyruvate and adenosine with 0.5–1.0 mm DNP infusion, were comparable to those induced by 3 h of sleep deprivation. Here we show that energy depletion in localized brain areas can generate sleep. The energy depletion model of sleep induction could be applied to in vitro research into the cellular mechanisms of prolonged wakefulness. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Local energy depletion in the basal forebrain increases sleep.
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  Data: <searchLink fieldCode="AR" term="%22Kalinchuk%2C+Anna+V%2E%22">Kalinchuk, Anna V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Urrila%2C+Anna‐Sofia%22">Urrila, Anna‐Sofia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alanko%2C+Lauri%22">Alanko, Lauri</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heiskanen%2C+Silja%22">Heiskanen, Silja</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wigren%2C+Henna‐Kaisa%22">Wigren, Henna‐Kaisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Suomela%2C+Maricel%22">Suomela, Maricel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stenberg%2C+Dag%22">Stenberg, Dag</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Porkka‐Heiskanen%2C+Tarja%22">Porkka‐Heiskanen, Tarja</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Feb2003, Vol. 17 Issue 4, p863-869. 0p.
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  Data: <searchLink fieldCode="DE" term="%22Basal+ganglia%22">Basal ganglia</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep%22">Sleep</searchLink><br /><searchLink fieldCode="DE" term="%22Dinitrophenol%22">Dinitrophenol</searchLink><br /><searchLink fieldCode="DE" term="%22Energy+metabolism%22">Energy metabolism</searchLink>
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  Data: Abstract Sleep saves energy, but can brain energy depletion induce sleep? We used 2,4-dinitrophenol (DNP), a molecule which prevents the synthesis of ATP, to induce local energy depletion in the basal forebrain of rats. Three-hour DNP infusions induced elevations in extracellular concentrations of lactate, pyruvate and adenosine, as well as increases in non-REM sleep during the following night. Sleep was not affected when DNP was administered to adjacent brain areas, although the metabolic changes were similar. The amount and the timing of the increase in non-REM sleep, as well as in the concentrations of lactate, pyruvate and adenosine with 0.5–1.0 mm DNP infusion, were comparable to those induced by 3 h of sleep deprivation. Here we show that energy depletion in localized brain areas can generate sleep. The energy depletion model of sleep induction could be applied to in vitro research into the cellular mechanisms of prolonged wakefulness. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1046/j.1460-9568.2003.02532.x
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      – SubjectFull: Dinitrophenol
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              Text: Feb2003
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