Cortical interneurons that specialize in disinhibitory control.
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| Title: | Cortical interneurons that specialize in disinhibitory control. |
|---|---|
| Authors: | Pi, Hyun-Jae, Hangya, Balázs, Kvitsiani, Duda, Sanders, Joshua I., Huang, Z. Josh, Kepecs, Adam |
| Source: | Nature. 11/28/2013, Vol. 503 Issue 7477, p521-524. 4p. |
| Subjects: | Interneurons, Cerebral cortex, Mammalogical research, Laboratory mice, Auditory cortex, Parvalbumins |
| Abstract: | In the mammalian cerebral cortex the diversity of interneuronal subtypes underlies a division of labour subserving distinct modes of inhibitory control. A unique mode of inhibitory control may be provided by inhibitory neurons that specifically suppress the firing of other inhibitory neurons. Such disinhibition could lead to the selective amplification of local processing and serve the important computational functions of gating and gain modulation. Although several interneuron populations are known to target other interneurons to varying degrees, little is known about interneurons specializing in disinhibition and their in vivo function. Here we show that a class of interneurons that express vasoactive intestinal polypeptide (VIP) mediates disinhibitory control in multiple areas of neocortex and is recruited by reinforcement signals. By combining optogenetic activation with single-cell recordings, we examined the functional role of VIP interneurons in awake mice, and investigated the underlying circuit mechanisms in vitro in auditory and medial prefrontal cortices. We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively. During the performance of an auditory discrimination task, reinforcement signals (reward and punishment) strongly and uniformly activated VIP neurons in auditory cortex, and in turn VIP recruitment increased the gain of a functional subpopulation of principal neurons. These results reveal a specific cell type and microcircuit underlying disinhibitory control in cortex and demonstrate that it is activated under specific behavioural conditions. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 92660250 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Cortical interneurons that specialize in disinhibitory control. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Pi%2C+Hyun-Jae%22">Pi, Hyun-Jae</searchLink><br /><searchLink fieldCode="AR" term="%22Hangya%2C+Balázs%22">Hangya, Balázs</searchLink><br /><searchLink fieldCode="AR" term="%22Kvitsiani%2C+Duda%22">Kvitsiani, Duda</searchLink><br /><searchLink fieldCode="AR" term="%22Sanders%2C+Joshua+I%2E%22">Sanders, Joshua I.</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+Z%2E+Josh%22">Huang, Z. Josh</searchLink><br /><searchLink fieldCode="AR" term="%22Kepecs%2C+Adam%22">Kepecs, Adam</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 11/28/2013, Vol. 503 Issue 7477, p521-524. 4p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Interneurons%22">Interneurons</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+cortex%22">Cerebral cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Mammalogical+research%22">Mammalogical research</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Auditory+cortex%22">Auditory cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Parvalbumins%22">Parvalbumins</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: In the mammalian cerebral cortex the diversity of interneuronal subtypes underlies a division of labour subserving distinct modes of inhibitory control. A unique mode of inhibitory control may be provided by inhibitory neurons that specifically suppress the firing of other inhibitory neurons. Such disinhibition could lead to the selective amplification of local processing and serve the important computational functions of gating and gain modulation. Although several interneuron populations are known to target other interneurons to varying degrees, little is known about interneurons specializing in disinhibition and their in vivo function. Here we show that a class of interneurons that express vasoactive intestinal polypeptide (VIP) mediates disinhibitory control in multiple areas of neocortex and is recruited by reinforcement signals. By combining optogenetic activation with single-cell recordings, we examined the functional role of VIP interneurons in awake mice, and investigated the underlying circuit mechanisms in vitro in auditory and medial prefrontal cortices. We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively. During the performance of an auditory discrimination task, reinforcement signals (reward and punishment) strongly and uniformly activated VIP neurons in auditory cortex, and in turn VIP recruitment increased the gain of a functional subpopulation of principal neurons. These results reveal a specific cell type and microcircuit underlying disinhibitory control in cortex and demonstrate that it is activated under specific behavioural conditions. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nature12676 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 521 Subjects: – SubjectFull: Interneurons Type: general – SubjectFull: Cerebral cortex Type: general – SubjectFull: Mammalogical research Type: general – SubjectFull: Laboratory mice Type: general – SubjectFull: Auditory cortex Type: general – SubjectFull: Parvalbumins Type: general Titles: – TitleFull: Cortical interneurons that specialize in disinhibitory control. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Pi, Hyun-Jae – PersonEntity: Name: NameFull: Hangya, Balázs – PersonEntity: Name: NameFull: Kvitsiani, Duda – PersonEntity: Name: NameFull: Sanders, Joshua I. – PersonEntity: Name: NameFull: Huang, Z. Josh – PersonEntity: Name: NameFull: Kepecs, Adam IsPartOfRelationships: – BibEntity: Dates: – D: 28 M: 11 Text: 11/28/2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 00280836 Numbering: – Type: volume Value: 503 – Type: issue Value: 7477 Titles: – TitleFull: Nature Type: main |
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