View in EDS HTML Full Text PDF Full Text

Body mass index and brain structure in healthy children and adolescents.

Saved in:
Bibliographic Details
Title: Body mass index and brain structure in healthy children and adolescents.
Authors: Alosco, Michael L. (AUTHOR), Stanek, Kelly M. (AUTHOR), Galioto, Rachel (AUTHOR), Korgaonkar, Mayuresh S. (AUTHOR), Grieve, Stuart M. (AUTHOR), Brickman, Adam M. (AUTHOR), Spitznagel, Mary Beth (AUTHOR), Gunstad, John (AUTHOR)
Source: International Journal of Neuroscience. Jan2014, Vol. 124 Issue 1, p49-55. 7p.
Subjects: Body mass index, Brain, Radiography, Brain injuries, Head injuries, Pyramidal neurons, Subconsciousness
Abstract: Obesity is associated with cognitive dysfunction in children and adolescents, although the mechanisms underlying these deficits remain unclear. This study examined the associations between body mass index (BMI) and regional gray matter volume and white matter integrity in 120 healthy children and adolescents (6-18 years of age) who underwent magnetic resonance and diffusion tensor imaging. Bonferroni-corrected partial correlation analyses controlling for demographic and clinical characteristics revealed significant inverse associations between demographically standardized BMI values and gray matter volume of frontal ( r = −0.31) and limbic ( r = −0.35) brain regions. No such pattern emerged for fractional anisotropy of white matter tracts. Subsequent hierarchical regression analyses indicated that the relationship between standardized BMI and structural gray and white matter brain indices did not vary with age. These findings suggest that obesity in children and adolescents is associated with decreased volume of frontal and limbic cerebral gray matter regions. Further research is much needed to better elucidate possible brain-based mechanisms for cognitive dysfunction associated with obesity. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 92707698
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Body mass index and brain structure in healthy children and adolescents.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Alosco%2C+Michael+L%2E%22">Alosco, Michael L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stanek%2C+Kelly+M%2E%22">Stanek, Kelly M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Galioto%2C+Rachel%22">Galioto, Rachel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Korgaonkar%2C+Mayuresh+S%2E%22">Korgaonkar, Mayuresh S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grieve%2C+Stuart+M%2E%22">Grieve, Stuart M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brickman%2C+Adam+M%2E%22">Brickman, Adam M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Spitznagel%2C+Mary+Beth%22">Spitznagel, Mary Beth</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gunstad%2C+John%22">Gunstad, John</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Jan2014, Vol. 124 Issue 1, p49-55. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Body+mass+index%22">Body mass index</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Radiography%22">Radiography</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+injuries%22">Brain injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Head+injuries%22">Head injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Pyramidal+neurons%22">Pyramidal neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Subconsciousness%22">Subconsciousness</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Obesity is associated with cognitive dysfunction in children and adolescents, although the mechanisms underlying these deficits remain unclear. This study examined the associations between body mass index (BMI) and regional gray matter volume and white matter integrity in 120 healthy children and adolescents (6-18 years of age) who underwent magnetic resonance and diffusion tensor imaging. Bonferroni-corrected partial correlation analyses controlling for demographic and clinical characteristics revealed significant inverse associations between demographically standardized BMI values and gray matter volume of frontal ( r = −0.31) and limbic ( r = −0.35) brain regions. No such pattern emerged for fractional anisotropy of white matter tracts. Subsequent hierarchical regression analyses indicated that the relationship between standardized BMI and structural gray and white matter brain indices did not vary with age. These findings suggest that obesity in children and adolescents is associated with decreased volume of frontal and limbic cerebral gray matter regions. Further research is much needed to better elucidate possible brain-based mechanisms for cognitive dysfunction associated with obesity. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=92707698
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3109/00207454.2013.817408
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 49
    Subjects:
      – SubjectFull: Body mass index
        Type: general
      – SubjectFull: Brain
        Type: general
      – SubjectFull: Radiography
        Type: general
      – SubjectFull: Brain injuries
        Type: general
      – SubjectFull: Head injuries
        Type: general
      – SubjectFull: Pyramidal neurons
        Type: general
      – SubjectFull: Subconsciousness
        Type: general
    Titles:
      – TitleFull: Body mass index and brain structure in healthy children and adolescents.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Alosco, Michael L.
      – PersonEntity:
          Name:
            NameFull: Stanek, Kelly M.
      – PersonEntity:
          Name:
            NameFull: Galioto, Rachel
      – PersonEntity:
          Name:
            NameFull: Korgaonkar, Mayuresh S.
      – PersonEntity:
          Name:
            NameFull: Grieve, Stuart M.
      – PersonEntity:
          Name:
            NameFull: Brickman, Adam M.
      – PersonEntity:
          Name:
            NameFull: Spitznagel, Mary Beth
      – PersonEntity:
          Name:
            NameFull: Gunstad, John
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan2014
              Type: published
              Y: 2014
          Identifiers:
            – Type: issn-print
              Value: 00207454
          Numbering:
            – Type: volume
              Value: 124
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: International Journal of Neuroscience
              Type: main
ResultId 1