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Antibodies to clustered acetylcholine receptor: expanding the phenotype.

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Title: Antibodies to clustered acetylcholine receptor: expanding the phenotype.
Authors: Devic, P., Petiot, P., Simonet, T., Stojkovic, T., Delmont, E., Franques, J., Magot, A., Vial, C., Lagrange, E., Nicot, A. S., Risson, V., Eymard, B., Schaeffer, L.
Source: European Journal of Neurology. Jan2014, Vol. 21 Issue 1, p130-134. 5p.
Subjects: Phenotypes, Immunoglobulins, Immunosuppressive agents, Thymoma, Cholinergic receptor research
Abstract: Background and purpose To provide a detailed phenotypical description of seronegative patients with generalized myasthenia gravis and antibodies to clustered acetylcholine receptors ( AChRs) and to assess their frequency amongst a French seronegative generalized myasthenia gravis ( SNMG) population. Methods A French SNMG database was created and the sera from the 37 patients included in it were analysed by immunofluorescence of cell-based assays using cotransfection of AChR subunit genes together with rapsyn to densely cluster the AChRs. Results Sixteen per cent ( n = 6) of the SNMG patients were found to have antibodies to clustered AChR. They presented either with early onset MG and thymic hyperplasia, late onset MG and thymic involution, or thymoma associated MG. They responded well to cholinesterase inhibitors and immunosuppressants. Conclusions Patients with antibodies to clustered AChR account for a significant proportion of SNMG patients and resemble patients with AChR antibodies detected by standard radio-immunoprecipitation. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Antibodies to clustered acetylcholine receptor: expanding the phenotype.
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  Data: <searchLink fieldCode="AR" term="%22Devic%2C+P%2E%22">Devic, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Petiot%2C+P%2E%22">Petiot, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Simonet%2C+T%2E%22">Simonet, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Stojkovic%2C+T%2E%22">Stojkovic, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Delmont%2C+E%2E%22">Delmont, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Franques%2C+J%2E%22">Franques, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Magot%2C+A%2E%22">Magot, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Vial%2C+C%2E%22">Vial, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Lagrange%2C+E%2E%22">Lagrange, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Nicot%2C+A%2E+S%2E%22">Nicot, A. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Risson%2C+V%2E%22">Risson, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Eymard%2C+B%2E%22">Eymard, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Schaeffer%2C+L%2E%22">Schaeffer, L.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Jan2014, Vol. 21 Issue 1, p130-134. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Phenotypes%22">Phenotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoglobulins%22">Immunoglobulins</searchLink><br /><searchLink fieldCode="DE" term="%22Immunosuppressive+agents%22">Immunosuppressive agents</searchLink><br /><searchLink fieldCode="DE" term="%22Thymoma%22">Thymoma</searchLink><br /><searchLink fieldCode="DE" term="%22Cholinergic+receptor+research%22">Cholinergic receptor research</searchLink>
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  Data: Background and purpose To provide a detailed phenotypical description of seronegative patients with generalized myasthenia gravis and antibodies to clustered acetylcholine receptors ( AChRs) and to assess their frequency amongst a French seronegative generalized myasthenia gravis ( SNMG) population. Methods A French SNMG database was created and the sera from the 37 patients included in it were analysed by immunofluorescence of cell-based assays using cotransfection of AChR subunit genes together with rapsyn to densely cluster the AChRs. Results Sixteen per cent ( n = 6) of the SNMG patients were found to have antibodies to clustered AChR. They presented either with early onset MG and thymic hyperplasia, late onset MG and thymic involution, or thymoma associated MG. They responded well to cholinesterase inhibitors and immunosuppressants. Conclusions Patients with antibodies to clustered AChR account for a significant proportion of SNMG patients and resemble patients with AChR antibodies detected by standard radio-immunoprecipitation. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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