Programming of glucose-insulin homoeostasis: long-term consequences of pre-natal versus early post-natal nutrition insults. Evidence from a sheep model.
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| Title: | Programming of glucose-insulin homoeostasis: long-term consequences of pre-natal versus early post-natal nutrition insults. Evidence from a sheep model. |
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| Authors: | Kongsted, A. H., Tygesen, M. P., Husted, S. V., Oliver, M. H., Tolver, A., Christensen, V. G., Nielsen, J. H., Nielsen, M. O. |
| Source: | Acta Physiologica. Jan2014, Vol. 210 Issue 1, p84-98. 15p. 2 Color Photographs, 3 Charts, 4 Graphs. |
| Subjects: | Metabolic disorder treatment, Sheep as laboratory animals, Nutrition in pregnancy, Insulin resistance, Diet in animal diseases |
| Abstract: | Aim Exposure to adverse intra-uterine conditions can predispose for metabolic disorders later in life. By using a sheep model, we studied (i) how programming of glucose-insulin homoeostasis during late gestation is manifested later in life depending on the early post-natal dietary exposure and (ii) whether dietary alteration in obese individuals can prevent adverse outcomes of early life programming. Methods During late gestation, twin-pregnant sheep were fed 100% ( NORM) or 50% ( LOW) of energy and protein requirements. After birth, offspring were exposed to a moderate ( CONV) or high-carbohydrate-high-fat ( HCHF) diet until around puberty. Offspring remaining thereafter (exclusively females) were fed a moderate diet until young adulthood. Results LOW lambs had increased insulin secretory responses during intravenous glucose tolerance tests indicative of reduced insulin sensitivity. HCHF lambs were hypertriglyceridaemic, 75% had mild pancreatic collagen infiltration, and their acute insulin secretory response and insulin clearance during intravenous glucose and insulin tolerance tests, respectively, were reduced. However, NORM- HCHF in contrast to LOW- HCHF lambs had normal glucose tolerance, indicating that later health outcomes are highly influenced by pre-natal nutrition. Dietary alteration normalized glucose-insulin homoeostasis in adult HCHF females, whereas late-gestation undernutrition ( LOW) permanently depressed insulin sensitivity. Conclusion Maintenance of glucose tolerance in sheep exposed to pre-natal undernutrition relied on pancreatic hypersecretion of insulin to compensate for reduced insulin sensitivity. A mismatching high-fat diet in early post-natal life interfered with this pancreatic hypersecretion resulting in reduced glucose tolerance. Early post-natal, but not late pre-natal, impacts on glucose-insulin homoeostasis could be reversed by dietary correction later in life. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 92941306 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Programming of glucose-insulin homoeostasis: long-term consequences of pre-natal versus early post-natal nutrition insults. Evidence from a sheep model. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kongsted%2C+A%2E+H%2E%22">Kongsted, A. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Tygesen%2C+M%2E+P%2E%22">Tygesen, M. P.</searchLink><br /><searchLink fieldCode="AR" term="%22Husted%2C+S%2E+V%2E%22">Husted, S. V.</searchLink><br /><searchLink fieldCode="AR" term="%22Oliver%2C+M%2E+H%2E%22">Oliver, M. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Tolver%2C+A%2E%22">Tolver, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Christensen%2C+V%2E+G%2E%22">Christensen, V. G.</searchLink><br /><searchLink fieldCode="AR" term="%22Nielsen%2C+J%2E+H%2E%22">Nielsen, J. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Nielsen%2C+M%2E+O%2E%22">Nielsen, M. O.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Jan2014, Vol. 210 Issue 1, p84-98. 15p. 2 Color Photographs, 3 Charts, 4 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Metabolic+disorder+treatment%22">Metabolic disorder treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Sheep+as+laboratory+animals%22">Sheep as laboratory animals</searchLink><br /><searchLink fieldCode="DE" term="%22Nutrition+in+pregnancy%22">Nutrition in pregnancy</searchLink><br /><searchLink fieldCode="DE" term="%22Insulin+resistance%22">Insulin resistance</searchLink><br /><searchLink fieldCode="DE" term="%22Diet+in+animal+diseases%22">Diet in animal diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Aim Exposure to adverse intra-uterine conditions can predispose for metabolic disorders later in life. By using a sheep model, we studied (i) how programming of glucose-insulin homoeostasis during late gestation is manifested later in life depending on the early post-natal dietary exposure and (ii) whether dietary alteration in obese individuals can prevent adverse outcomes of early life programming. Methods During late gestation, twin-pregnant sheep were fed 100% ( NORM) or 50% ( LOW) of energy and protein requirements. After birth, offspring were exposed to a moderate ( CONV) or high-carbohydrate-high-fat ( HCHF) diet until around puberty. Offspring remaining thereafter (exclusively females) were fed a moderate diet until young adulthood. Results LOW lambs had increased insulin secretory responses during intravenous glucose tolerance tests indicative of reduced insulin sensitivity. HCHF lambs were hypertriglyceridaemic, 75% had mild pancreatic collagen infiltration, and their acute insulin secretory response and insulin clearance during intravenous glucose and insulin tolerance tests, respectively, were reduced. However, NORM- HCHF in contrast to LOW- HCHF lambs had normal glucose tolerance, indicating that later health outcomes are highly influenced by pre-natal nutrition. Dietary alteration normalized glucose-insulin homoeostasis in adult HCHF females, whereas late-gestation undernutrition ( LOW) permanently depressed insulin sensitivity. Conclusion Maintenance of glucose tolerance in sheep exposed to pre-natal undernutrition relied on pancreatic hypersecretion of insulin to compensate for reduced insulin sensitivity. A mismatching high-fat diet in early post-natal life interfered with this pancreatic hypersecretion resulting in reduced glucose tolerance. Early post-natal, but not late pre-natal, impacts on glucose-insulin homoeostasis could be reversed by dietary correction later in life. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/apha.12080 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 84 Subjects: – SubjectFull: Metabolic disorder treatment Type: general – SubjectFull: Sheep as laboratory animals Type: general – SubjectFull: Nutrition in pregnancy Type: general – SubjectFull: Insulin resistance Type: general – SubjectFull: Diet in animal diseases Type: general Titles: – TitleFull: Programming of glucose-insulin homoeostasis: long-term consequences of pre-natal versus early post-natal nutrition insults. Evidence from a sheep model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kongsted, A. H. – PersonEntity: Name: NameFull: Tygesen, M. P. – PersonEntity: Name: NameFull: Husted, S. V. – PersonEntity: Name: NameFull: Oliver, M. H. – PersonEntity: Name: NameFull: Tolver, A. – PersonEntity: Name: NameFull: Christensen, V. G. – PersonEntity: Name: NameFull: Nielsen, J. H. – PersonEntity: Name: NameFull: Nielsen, M. O. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 17481708 Numbering: – Type: volume Value: 210 – Type: issue Value: 1 Titles: – TitleFull: Acta Physiologica Type: main |
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