View in EDS HTML Full Text PDF Full Text

Randomized controlled trial of aripiprazole versus risperidone for the treatment of amphetamine-induced psychosis.

Saved in:
Bibliographic Details
Title: Randomized controlled trial of aripiprazole versus risperidone for the treatment of amphetamine-induced psychosis.
Authors: Farnia, Vahid (AUTHOR), Shakeri, Jalal (AUTHOR), Tatari, Faezeh (AUTHOR), Juibari, Toraj Ahmadi (AUTHOR), Yazdchi, Katayoun (AUTHOR), Bajoghli, Hafez (AUTHOR), Brand, Serge (AUTHOR), Abdoli, Nasrin (AUTHOR), Aghaei, Abbas (AUTHOR)
Source: American Journal of Drug & Alcohol Abuse. 2014, Vol. 40 Issue 1, p10-15. 6p.
Subjects: Amphetamines, Disease prevalence, Methamphetamine abuse, Psychiatric treatment, Psychoses, Randomized controlled trials, Risperidone, Aripiprazole
Abstract: Background: Lifetime prevalence of amphetamine-induced psychotic disorder is reported as being up to 23% for methamphetamine (MA) abusers. Approximately 25% of those with a baseline DSM-IV diagnosis of substance-induced psychosis are diagnosed with primary psychosis at one-year follow-up. Evidence on the treatment of amphetamine psychosis is very limited. Objectives: To investigate the efficacy of risperidone versus aripiprazole in treatment of amphetamine-induced psychotic symptoms. Methods: In a double-blind study, 45 participants were randomly allocated to either aripiprazole 15 mg or risperidone 4 mg daily over a six-week trial. Positive and negative symptoms of psychosis were assessed using the Scale for Assessment of Negative Symptoms (SANS) and the Scale for Assessment of Positive Symptoms (SAPS) at baseline and completion of the trial. Results: SANS and SAPS scores decreased significantly in both groups. Mean SAPS score reduction in risperidone and aripiprazole group was 16.20 and 10.80, respectively, after trial course ( p < 0.001). Mean SANS score reduction in risperidone and aripiprazole group was 9.35 and 11.25, respectively ( p = 0.08). Conclusions: Both aripiprazole and risperidone were effective for patients diagnosed with amphetamine-induced psychotic disorder. However, risperidone had the greater effect on positive psychotic symptoms while patients with negative symptoms may respond better to aripiprazole. There is a case for further studies evaluating the efficacy of atypical antipsychotics in this disorder. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 93303971
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Randomized controlled trial of aripiprazole versus risperidone for the treatment of amphetamine-induced psychosis.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Farnia%2C+Vahid%22&quot;&gt;Farnia, Vahid&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shakeri%2C+Jalal%22&quot;&gt;Shakeri, Jalal&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tatari%2C+Faezeh%22&quot;&gt;Tatari, Faezeh&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Juibari%2C+Toraj+Ahmadi%22&quot;&gt;Juibari, Toraj Ahmadi&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yazdchi%2C+Katayoun%22&quot;&gt;Yazdchi, Katayoun&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bajoghli%2C+Hafez%22&quot;&gt;Bajoghli, Hafez&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Brand%2C+Serge%22&quot;&gt;Brand, Serge&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Abdoli%2C+Nasrin%22&quot;&gt;Abdoli, Nasrin&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Aghaei%2C+Abbas%22&quot;&gt;Aghaei, Abbas&lt;/searchLink&gt; (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22American+Journal+of+Drug+%26+Alcohol+Abuse%22&quot;&gt;American Journal of Drug &amp; Alcohol Abuse&lt;/searchLink&gt;. 2014, Vol. 40 Issue 1, p10-15. 6p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Amphetamines%22&quot;&gt;Amphetamines&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Disease+prevalence%22&quot;&gt;Disease prevalence&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Methamphetamine+abuse%22&quot;&gt;Methamphetamine abuse&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Psychiatric+treatment%22&quot;&gt;Psychiatric treatment&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Psychoses%22&quot;&gt;Psychoses&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Randomized+controlled+trials%22&quot;&gt;Randomized controlled trials&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Risperidone%22&quot;&gt;Risperidone&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Aripiprazole%22&quot;&gt;Aripiprazole&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Lifetime prevalence of amphetamine-induced psychotic disorder is reported as being up to 23% for methamphetamine (MA) abusers. Approximately 25% of those with a baseline DSM-IV diagnosis of substance-induced psychosis are diagnosed with primary psychosis at one-year follow-up. Evidence on the treatment of amphetamine psychosis is very limited. Objectives: To investigate the efficacy of risperidone versus aripiprazole in treatment of amphetamine-induced psychotic symptoms. Methods: In a double-blind study, 45 participants were randomly allocated to either aripiprazole 15 mg or risperidone 4 mg daily over a six-week trial. Positive and negative symptoms of psychosis were assessed using the Scale for Assessment of Negative Symptoms (SANS) and the Scale for Assessment of Positive Symptoms (SAPS) at baseline and completion of the trial. Results: SANS and SAPS scores decreased significantly in both groups. Mean SAPS score reduction in risperidone and aripiprazole group was 16.20 and 10.80, respectively, after trial course ( p &lt; 0.001). Mean SANS score reduction in risperidone and aripiprazole group was 9.35 and 11.25, respectively ( p = 0.08). Conclusions: Both aripiprazole and risperidone were effective for patients diagnosed with amphetamine-induced psychotic disorder. However, risperidone had the greater effect on positive psychotic symptoms while patients with negative symptoms may respond better to aripiprazole. There is a case for further studies evaluating the efficacy of atypical antipsychotics in this disorder. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of American Journal of Drug &amp; Alcohol Abuse is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=93303971
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3109/00952990.2013.861843
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 10
    Subjects:
      – SubjectFull: Amphetamines
        Type: general
      – SubjectFull: Disease prevalence
        Type: general
      – SubjectFull: Methamphetamine abuse
        Type: general
      – SubjectFull: Psychiatric treatment
        Type: general
      – SubjectFull: Psychoses
        Type: general
      – SubjectFull: Randomized controlled trials
        Type: general
      – SubjectFull: Risperidone
        Type: general
      – SubjectFull: Aripiprazole
        Type: general
    Titles:
      – TitleFull: Randomized controlled trial of aripiprazole versus risperidone for the treatment of amphetamine-induced psychosis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Farnia, Vahid
      – PersonEntity:
          Name:
            NameFull: Shakeri, Jalal
      – PersonEntity:
          Name:
            NameFull: Tatari, Faezeh
      – PersonEntity:
          Name:
            NameFull: Juibari, Toraj Ahmadi
      – PersonEntity:
          Name:
            NameFull: Yazdchi, Katayoun
      – PersonEntity:
          Name:
            NameFull: Bajoghli, Hafez
      – PersonEntity:
          Name:
            NameFull: Brand, Serge
      – PersonEntity:
          Name:
            NameFull: Abdoli, Nasrin
      – PersonEntity:
          Name:
            NameFull: Aghaei, Abbas
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: 2014
              Type: published
              Y: 2014
          Identifiers:
            – Type: issn-print
              Value: 00952990
          Numbering:
            – Type: volume
              Value: 40
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: American Journal of Drug & Alcohol Abuse
              Type: main
ResultId 1