View in EDS PDF Full Text

The MTHFR C677T polymorphism modifies age at onset in Parkinson's disease.

Saved in:
Bibliographic Details
Title: The MTHFR C677T polymorphism modifies age at onset in Parkinson's disease.
Authors: Vallelunga, Annamaria, Pegoraro, Valentina, Pilleri, Manuela, Biundo, Roberta, Iuliis, Angela, Marchetti, Mauro, Facchini, Silvia, Formento Dojot, Patrizia, Antonini, Angelo
Source: Neurological Sciences. Jan2014, Vol. 35 Issue 1, p73-77. 5p.
Subjects: Genetic polymorphisms, Age of onset, Hyperhomocysteinemia, Disease risk factors, Parkinson's disease, Genetic mutation, Methylenetetrahydrofolate reductase, Homocysteine, Homozygosity
Abstract: Hyperhomocysteinemia is a risk factor for Parkinson's disease (PD) and may result from genetic mutations or/and environmental factors. 5,10-methylenetetrahydrofolate reductase (MTHFR) is a folate-dependent enzyme that catalyzed remethylation of homocysteine (Hcy) and the MTHFR C677T polymorphism makes the MTHFR enzyme thermolabile causing hyperhomocysteinemia. In this study we analyzed whether two functional polymorphisms of MTHFR gene, A1298C and C677T, affect age of onset in PD. We enrolled 120 patients with sporadic PD. Patients were divided into three groups based on MTHFR C677T polymorphisms: (a) homozygotes wild type (CC) (b) heterozygotes (CT) and (c) homozygotes carriers of mutation (TT). MTHFR SNPs were analyzed using High-Resolution Melt analysis and ANOVA was performed to assess whether polymorphisms of MTHFR gene could influence age of onset. The MTHFR A1298C polymorphism had no effect on PD age at onset ( p = 1.0) while there was a significant association with MTHFR C677T ( p = 0.019 Bonferroni-adjusted post hoc) showing an earlier onset in CC as compared with TT. ( p = 0.024). No differences were found for vascular load assessed with magnetic resonance imaging, pharmacological therapy and cognitive state for two MTHFR SNPs. Our results suggest a possible association of MTHFR C677T with age at onset of PD and may have important implications regarding the role of MTHFR. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 93448429
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: The MTHFR C677T polymorphism modifies age at onset in Parkinson's disease.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Vallelunga%2C+Annamaria%22">Vallelunga, Annamaria</searchLink><br /><searchLink fieldCode="AR" term="%22Pegoraro%2C+Valentina%22">Pegoraro, Valentina</searchLink><br /><searchLink fieldCode="AR" term="%22Pilleri%2C+Manuela%22">Pilleri, Manuela</searchLink><br /><searchLink fieldCode="AR" term="%22Biundo%2C+Roberta%22">Biundo, Roberta</searchLink><br /><searchLink fieldCode="AR" term="%22Iuliis%2C+Angela%22">Iuliis, Angela</searchLink><br /><searchLink fieldCode="AR" term="%22Marchetti%2C+Mauro%22">Marchetti, Mauro</searchLink><br /><searchLink fieldCode="AR" term="%22Facchini%2C+Silvia%22">Facchini, Silvia</searchLink><br /><searchLink fieldCode="AR" term="%22Formento+Dojot%2C+Patrizia%22">Formento Dojot, Patrizia</searchLink><br /><searchLink fieldCode="AR" term="%22Antonini%2C+Angelo%22">Antonini, Angelo</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Jan2014, Vol. 35 Issue 1, p73-77. 5p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Age+of+onset%22">Age of onset</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperhomocysteinemia%22">Hyperhomocysteinemia</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+mutation%22">Genetic mutation</searchLink><br /><searchLink fieldCode="DE" term="%22Methylenetetrahydrofolate+reductase%22">Methylenetetrahydrofolate reductase</searchLink><br /><searchLink fieldCode="DE" term="%22Homocysteine%22">Homocysteine</searchLink><br /><searchLink fieldCode="DE" term="%22Homozygosity%22">Homozygosity</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Hyperhomocysteinemia is a risk factor for Parkinson's disease (PD) and may result from genetic mutations or/and environmental factors. 5,10-methylenetetrahydrofolate reductase (MTHFR) is a folate-dependent enzyme that catalyzed remethylation of homocysteine (Hcy) and the MTHFR C677T polymorphism makes the MTHFR enzyme thermolabile causing hyperhomocysteinemia. In this study we analyzed whether two functional polymorphisms of MTHFR gene, A1298C and C677T, affect age of onset in PD. We enrolled 120 patients with sporadic PD. Patients were divided into three groups based on MTHFR C677T polymorphisms: (a) homozygotes wild type (CC) (b) heterozygotes (CT) and (c) homozygotes carriers of mutation (TT). MTHFR SNPs were analyzed using High-Resolution Melt analysis and ANOVA was performed to assess whether polymorphisms of MTHFR gene could influence age of onset. The MTHFR A1298C polymorphism had no effect on PD age at onset ( p = 1.0) while there was a significant association with MTHFR C677T ( p = 0.019 Bonferroni-adjusted post hoc) showing an earlier onset in CC as compared with TT. ( p = 0.024). No differences were found for vascular load assessed with magnetic resonance imaging, pharmacological therapy and cognitive state for two MTHFR SNPs. Our results suggest a possible association of MTHFR C677T with age at onset of PD and may have important implications regarding the role of MTHFR. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=93448429
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10072-013-1545-z
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 73
    Subjects:
      – SubjectFull: Genetic polymorphisms
        Type: general
      – SubjectFull: Age of onset
        Type: general
      – SubjectFull: Hyperhomocysteinemia
        Type: general
      – SubjectFull: Disease risk factors
        Type: general
      – SubjectFull: Parkinson's disease
        Type: general
      – SubjectFull: Genetic mutation
        Type: general
      – SubjectFull: Methylenetetrahydrofolate reductase
        Type: general
      – SubjectFull: Homocysteine
        Type: general
      – SubjectFull: Homozygosity
        Type: general
    Titles:
      – TitleFull: The MTHFR C677T polymorphism modifies age at onset in Parkinson's disease.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Vallelunga, Annamaria
      – PersonEntity:
          Name:
            NameFull: Pegoraro, Valentina
      – PersonEntity:
          Name:
            NameFull: Pilleri, Manuela
      – PersonEntity:
          Name:
            NameFull: Biundo, Roberta
      – PersonEntity:
          Name:
            NameFull: Iuliis, Angela
      – PersonEntity:
          Name:
            NameFull: Marchetti, Mauro
      – PersonEntity:
          Name:
            NameFull: Facchini, Silvia
      – PersonEntity:
          Name:
            NameFull: Formento Dojot, Patrizia
      – PersonEntity:
          Name:
            NameFull: Antonini, Angelo
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan2014
              Type: published
              Y: 2014
          Identifiers:
            – Type: issn-print
              Value: 15901874
          Numbering:
            – Type: volume
              Value: 35
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Neurological Sciences
              Type: main
ResultId 1