Soluble E-Selectin, Soluble L-Selectin and Soluble ICAM-1 in Bronchopulmonary Dysplasia, and Changes With Dexamethasone.
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| Title: | Soluble E-Selectin, Soluble L-Selectin and Soluble ICAM-1 in Bronchopulmonary Dysplasia, and Changes With Dexamethasone. |
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| Authors: | Kumari, Jaishree (AUTHOR), Ballabh, Praveen (AUTHOR), Krauss, Alfred N. (AUTHOR), Jain, Ajey (AUTHOR), Auld, Peter A. M. (AUTHOR), Shin, Junghee J. (AUTHOR), Cunningham-Rundles, Susanna (AUTHOR), Lesser, Martin L. (AUTHOR) |
| Source: | Pediatrics. Mar2003, Vol. 111 Issue 3, p461-468. 8p. 5 Graphs. |
| Subjects: | Cell adhesion molecules, Respiratory distress syndrome, Bronchopulmonary dysplasia, Neonatal diseases |
| Abstract: | Objective. To evaluate longitudinal change in arterial blood plasma levels of soluble adhesion molecules in infants of <30 weeks' gestation with respiratory distress syndrome (RDS) and to look for differences in these levels in neonates who subsequently developed bronchopulmonary dysplasia (BPD) compared with those neonates who did not, and also to investigate the effect of dexamethasone treatment on levels of soluble adhesion molecules in plasma. Methods. We measured plasma concentrations of soluble L-selectin (sL-selectin), soluble E-selectin (sE-selectin), and soluble intercellular adhesion molecule-1 on days 1, 3, 7, 14, 21, and 28 of life and before and 2 to 3 days after initiating a 6-day course of dexamethasone treatment. Infants with RDS were followed until discharge and were classified as non-BPD and either 1) BPD day 28 reflecting oxygen requirement on day 28 but not at 36 corrected weeks or 2) BPD 36 weeks reflecting oxygen requirement at 36 (corrected) weeks' gestation. The classification of presence or absence of BPD by oxygen requirement was supported by and was consistent with radiologic findings of BPD for all infants. The difference between BPD day 28 and BPD 36 weeks was supported by more extensive radiologic effects in the latter. Results. The arterial plasma level of sL-selectin in infants who had RDS and did not develop BPD was significantly decreased compared with term healthy infants, as was the level of sE-selectin. Compared with infants who had RDS and did not develop BPD, sL-selectin levels were even further decreased in infants who had RDS and did develop BPD both at birth and throughout the first 4 weeks of life (day 1 through day 28). Infants with BPD also showed increasing levels of sE-selectin during this period of time, whereas infants without BPD did not. Levels of soluble intercellular adhesion molecule-1 in infants without BPD were not different from infants with BPD initially but increased in infants with BPD compared with infant [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 9356401 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Soluble E-Selectin, Soluble L-Selectin and Soluble ICAM-1 in Bronchopulmonary Dysplasia, and Changes With Dexamethasone. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kumari%2C+Jaishree%22">Kumari, Jaishree</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ballabh%2C+Praveen%22">Ballabh, Praveen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Krauss%2C+Alfred+N%2E%22">Krauss, Alfred N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jain%2C+Ajey%22">Jain, Ajey</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Auld%2C+Peter+A%2E+M%2E%22">Auld, Peter A. M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shin%2C+Junghee+J%2E%22">Shin, Junghee J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cunningham-Rundles%2C+Susanna%22">Cunningham-Rundles, Susanna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lesser%2C+Martin+L%2E%22">Lesser, Martin L.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Mar2003, Vol. 111 Issue 3, p461-468. 8p. 5 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cell+adhesion+molecules%22">Cell adhesion molecules</searchLink><br /><searchLink fieldCode="DE" term="%22Respiratory+distress+syndrome%22">Respiratory distress syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Bronchopulmonary+dysplasia%22">Bronchopulmonary dysplasia</searchLink><br /><searchLink fieldCode="DE" term="%22Neonatal+diseases%22">Neonatal diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective. To evaluate longitudinal change in arterial blood plasma levels of soluble adhesion molecules in infants of <30 weeks' gestation with respiratory distress syndrome (RDS) and to look for differences in these levels in neonates who subsequently developed bronchopulmonary dysplasia (BPD) compared with those neonates who did not, and also to investigate the effect of dexamethasone treatment on levels of soluble adhesion molecules in plasma. Methods. We measured plasma concentrations of soluble L-selectin (sL-selectin), soluble E-selectin (sE-selectin), and soluble intercellular adhesion molecule-1 on days 1, 3, 7, 14, 21, and 28 of life and before and 2 to 3 days after initiating a 6-day course of dexamethasone treatment. Infants with RDS were followed until discharge and were classified as non-BPD and either 1) BPD day 28 reflecting oxygen requirement on day 28 but not at 36 corrected weeks or 2) BPD 36 weeks reflecting oxygen requirement at 36 (corrected) weeks' gestation. The classification of presence or absence of BPD by oxygen requirement was supported by and was consistent with radiologic findings of BPD for all infants. The difference between BPD day 28 and BPD 36 weeks was supported by more extensive radiologic effects in the latter. Results. The arterial plasma level of sL-selectin in infants who had RDS and did not develop BPD was significantly decreased compared with term healthy infants, as was the level of sE-selectin. Compared with infants who had RDS and did not develop BPD, sL-selectin levels were even further decreased in infants who had RDS and did develop BPD both at birth and throughout the first 4 weeks of life (day 1 through day 28). Infants with BPD also showed increasing levels of sE-selectin during this period of time, whereas infants without BPD did not. Levels of soluble intercellular adhesion molecule-1 in infants without BPD were not different from infants with BPD initially but increased in infants with BPD compared with infant [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 461 Subjects: – SubjectFull: Cell adhesion molecules Type: general – SubjectFull: Respiratory distress syndrome Type: general – SubjectFull: Bronchopulmonary dysplasia Type: general – SubjectFull: Neonatal diseases Type: general Titles: – TitleFull: Soluble E-Selectin, Soluble L-Selectin and Soluble ICAM-1 in Bronchopulmonary Dysplasia, and Changes With Dexamethasone. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kumari, Jaishree – PersonEntity: Name: NameFull: Ballabh, Praveen – PersonEntity: Name: NameFull: Krauss, Alfred N. – PersonEntity: Name: NameFull: Jain, Ajey – PersonEntity: Name: NameFull: Auld, Peter A. M. – PersonEntity: Name: NameFull: Shin, Junghee J. – PersonEntity: Name: NameFull: Cunningham-Rundles, Susanna – PersonEntity: Name: NameFull: Lesser, Martin L. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2003 Type: published Y: 2003 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 111 – Type: issue Value: 3 Titles: – TitleFull: Pediatrics Type: main |
| ResultId | 1 |
