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Review of the impact of NNRTI-based HIV treatment regimens on patient-reported disease burden.

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Title: Review of the impact of NNRTI-based HIV treatment regimens on patient-reported disease burden.
Authors: Simpson, Kit N. (AUTHOR), Hanson, Kristin A. (AUTHOR), Harding, Gale (AUTHOR), Haider, Seema (AUTHOR), Tawadrous, Margaret (AUTHOR), Khachatryan, Alexandra (AUTHOR), Pashos, Chris L. (AUTHOR), Wu, Albert W. (AUTHOR)
Source: AIDS Care. Apr2014, Vol. 26 Issue 4, p466-475. 10p.
Subjects: HIV infections, Mathematical models, MEDLINE, Online information services, Research funding, Systematic reviews, Theory, Descriptive statistics, Non-nucleoside reverse transcriptase inhibitors, Therapeutics
Abstract: While the burden of HIV disease is well documented, the value of non-nucleoside reverse transcriptase inhibitor (NNRTI)-based therapy regimens in reducing patient burden is not well understood. The purpose of this study was to examine patient-reported health among those receiving NNRTI-based regimens to understand their incremental value in reducing the burden of HIV. We conducted a structured literature review using PubMed to identify NNRTI trials utilizing validated patient-reported outcome (PRO) instruments during 2005–2011. The search strategy included a PubMed search to identify relevant studies based on disease, instrument, PRO, and NNRTI medication terms; and a manual search of bibliographies of identified papers. Data abstracted from each study included study type, treatment regimen(s), and PRO results. Of 11 trials identified, 8 (73%) reported significance of changes in a PRO over time and 10 (91%) reported significance of PRO changes between groups. Several domains were assessed, with significant findings (between or within groups) observed in: physical health/well-being (n= 5), emotional status/well-being (n= 2), symptoms (n= 2), anxiety (n= 2), gastrointestinal upset (n= 2), psychological health (n= 1), functional and global well-being (n= 1), fatigue/energy (n= 1), depression (n= 1), change in body appearance (n= 1), pain (n= 1), headache (n= 1), bad dreams/nightmares (n= 1), problems having sex (n= 1), and general health perception (n= 1). In conclusion, NNRTIs have been observed most frequently to improve patient-reported physical health and well-being. Treatments are needed that can also reduce patient burden in areas of emotional well-being, cognitive functioning, and overall symptom profile. [ABSTRACT FROM AUTHOR]
Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Review of the impact of NNRTI-based HIV treatment regimens on patient-reported disease burden.
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  Data: <searchLink fieldCode="AR" term="%22Simpson%2C+Kit+N%2E%22">Simpson, Kit N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hanson%2C+Kristin+A%2E%22">Hanson, Kristin A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Harding%2C+Gale%22">Harding, Gale</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Haider%2C+Seema%22">Haider, Seema</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tawadrous%2C+Margaret%22">Tawadrous, Margaret</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Khachatryan%2C+Alexandra%22">Khachatryan, Alexandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pashos%2C+Chris+L%2E%22">Pashos, Chris L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Albert+W%2E%22">Wu, Albert W.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22AIDS+Care%22">AIDS Care</searchLink>. Apr2014, Vol. 26 Issue 4, p466-475. 10p.
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  Data: <searchLink fieldCode="DE" term="%22HIV+infections%22">HIV infections</searchLink><br /><searchLink fieldCode="DE" term="%22Mathematical+models%22">Mathematical models</searchLink><br /><searchLink fieldCode="DE" term="%22MEDLINE%22">MEDLINE</searchLink><br /><searchLink fieldCode="DE" term="%22Online+information+services%22">Online information services</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Systematic+reviews%22">Systematic reviews</searchLink><br /><searchLink fieldCode="DE" term="%22Theory%22">Theory</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Non-nucleoside+reverse+transcriptase+inhibitors%22">Non-nucleoside reverse transcriptase inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: While the burden of HIV disease is well documented, the value of non-nucleoside reverse transcriptase inhibitor (NNRTI)-based therapy regimens in reducing patient burden is not well understood. The purpose of this study was to examine patient-reported health among those receiving NNRTI-based regimens to understand their incremental value in reducing the burden of HIV. We conducted a structured literature review using PubMed to identify NNRTI trials utilizing validated patient-reported outcome (PRO) instruments during 2005–2011. The search strategy included a PubMed search to identify relevant studies based on disease, instrument, PRO, and NNRTI medication terms; and a manual search of bibliographies of identified papers. Data abstracted from each study included study type, treatment regimen(s), and PRO results. Of 11 trials identified, 8 (73%) reported significance of changes in a PRO over time and 10 (91%) reported significance of PRO changes between groups. Several domains were assessed, with significant findings (between or within groups) observed in: physical health/well-being (n= 5), emotional status/well-being (n= 2), symptoms (n= 2), anxiety (n= 2), gastrointestinal upset (n= 2), psychological health (n= 1), functional and global well-being (n= 1), fatigue/energy (n= 1), depression (n= 1), change in body appearance (n= 1), pain (n= 1), headache (n= 1), bad dreams/nightmares (n= 1), problems having sex (n= 1), and general health perception (n= 1). In conclusion, NNRTIs have been observed most frequently to improve patient-reported physical health and well-being. Treatments are needed that can also reduce patient burden in areas of emotional well-being, cognitive functioning, and overall symptom profile. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/09540121.2013.841825
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      – SubjectFull: HIV infections
        Type: general
      – SubjectFull: Mathematical models
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      – SubjectFull: MEDLINE
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Non-nucleoside reverse transcriptase inhibitors
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      – SubjectFull: Therapeutics
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              Text: Apr2014
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