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Receptor-selective changes in µ-, δ- and κ-opioid receptors after chronic naltrexone treatment in mice.

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Title: Receptor-selective changes in µ-, δ- and κ-opioid receptors after chronic naltrexone treatment in mice.
Authors: Lesscher, Heidi M. B. (AUTHOR), Bailey, Alexis (AUTHOR), Burbach, J. Peter H. (AUTHOR), Van Ree, Jan M. (AUTHOR), Kitchen, Ian (AUTHOR), Gerrits, Mirjam A. F. M. (AUTHOR)
Source: European Journal of Neuroscience. Mar2003, Vol. 17 Issue 5, p1006-1012. 0p. 3 Charts.
Subjects: Opioid receptors, Naltrexone, Mice, Therapeutics
Abstract: Abstract Chronic treatment with the opioid antagonist naltrexone induces functional supersensitivity to opioid agonists, which may be explained by receptor up-regulation induced by opioid receptor blockade. In the present study, the levels of opioid receptor subtypes through the brain of mice were determined after chronic naltrexone treatment using quantitative in vitro autoradiography. This is the first complete mapping study in mice for µ-, δ- and κ-opioid receptors after chronic naltrexone exposure. Treatment with naltrexone clearly induced up-regulation of µ- (mean 80%) and, to a lesser extent, δ-opioid receptors (mean 39%). The up-regulation of µ- and δ-opioid receptors was evident throughout the brain, although there was variation in the percentage change across brain regions. In contrast, consistent up-regulation of κ-opioid receptors was observed in cortical structures only and was not so marked as for µ- and δ-opioid receptors. In noncortical regions κ-opioid receptor expression was unchanged. Taken together, the present findings suggest opioid receptor subtype-selective regulation by chronic naltrexone treatment in mice. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Receptor-selective changes in µ-, δ- and κ-opioid receptors after chronic naltrexone treatment in mice.
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Mar2003, Vol. 17 Issue 5, p1006-1012. 0p. 3 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Opioid+receptors%22">Opioid receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Naltrexone%22">Naltrexone</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%22">Mice</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
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  Data: Abstract Chronic treatment with the opioid antagonist naltrexone induces functional supersensitivity to opioid agonists, which may be explained by receptor up-regulation induced by opioid receptor blockade. In the present study, the levels of opioid receptor subtypes through the brain of mice were determined after chronic naltrexone treatment using quantitative in vitro autoradiography. This is the first complete mapping study in mice for µ-, δ- and κ-opioid receptors after chronic naltrexone exposure. Treatment with naltrexone clearly induced up-regulation of µ- (mean 80%) and, to a lesser extent, δ-opioid receptors (mean 39%). The up-regulation of µ- and δ-opioid receptors was evident throughout the brain, although there was variation in the percentage change across brain regions. In contrast, consistent up-regulation of κ-opioid receptors was observed in cortical structures only and was not so marked as for µ- and δ-opioid receptors. In noncortical regions κ-opioid receptor expression was unchanged. Taken together, the present findings suggest opioid receptor subtype-selective regulation by chronic naltrexone treatment in mice. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1046/j.1460-9568.2003.02502.x
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