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A Structurally Distinct Human Mycoplasma Protein that Generically Blocks Antigen-Antibody Union.

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Title: A Structurally Distinct Human Mycoplasma Protein that Generically Blocks Antigen-Antibody Union.
Authors: Grover, Rajesh K., Xueyong Zhu, Nieusma, Travis, Jones, Teresa, Boero, Isabel, MacLeod, Amanda S., Mark, Adam, Niessen, Sherry, Kim, Helen J., Kong, Leopold, Assad-Garcia, Nacyra, Kwon, Keehwan, Chesi, Marta, Smider, Vaughn V., Salomon, Daniel R., Jelinek, Diane F., Kyle, Robert A., Pyles, Richard B., Glass, John I., Ward, Andrew B.
Source: Science (pre-March 2025). 2/7/2014, Vol. 343 Issue 6171, p656-661. 6p.
Subjects: Mycoplasma, Antigen-antibody reactions, Crystal structure, Membrane proteins, Protein structure, Immunoglobulin G, Antigens
Abstract: We report the discovery of a broadly reactive antibody-binding protein (Protein M) from human mycoplasma. The crystal structure of the ectodomain of transmembrane Protein M differs from other known protein structures, as does its mechanism of antibody binding. Protein M binds with high affinity to all types of human and nonhuman immunoglobulin G, predominantly through attachment to the conserved portions of the variable region of the k and l light chains. Protein M blocks antibody-antigen union, likely because of its large C-terminal domain extending over the antibody-combining site, blocking entry to large antigens. Similar to the other immunoglobulin-binding proteins such as Protein A, Protein M as well as its orthologs in other Mycoplasma species could become invaluable reagents in the antibody field. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Data: A Structurally Distinct Human Mycoplasma Protein that Generically Blocks Antigen-Antibody Union.
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  Data: <searchLink fieldCode="AR" term="%22Grover%2C+Rajesh+K%2E%22">Grover, Rajesh K.</searchLink><br /><searchLink fieldCode="AR" term="%22Xueyong+Zhu%22">Xueyong Zhu</searchLink><br /><searchLink fieldCode="AR" term="%22Nieusma%2C+Travis%22">Nieusma, Travis</searchLink><br /><searchLink fieldCode="AR" term="%22Jones%2C+Teresa%22">Jones, Teresa</searchLink><br /><searchLink fieldCode="AR" term="%22Boero%2C+Isabel%22">Boero, Isabel</searchLink><br /><searchLink fieldCode="AR" term="%22MacLeod%2C+Amanda+S%2E%22">MacLeod, Amanda S.</searchLink><br /><searchLink fieldCode="AR" term="%22Mark%2C+Adam%22">Mark, Adam</searchLink><br /><searchLink fieldCode="AR" term="%22Niessen%2C+Sherry%22">Niessen, Sherry</searchLink><br /><searchLink fieldCode="AR" term="%22Kim%2C+Helen+J%2E%22">Kim, Helen J.</searchLink><br /><searchLink fieldCode="AR" term="%22Kong%2C+Leopold%22">Kong, Leopold</searchLink><br /><searchLink fieldCode="AR" term="%22Assad-Garcia%2C+Nacyra%22">Assad-Garcia, Nacyra</searchLink><br /><searchLink fieldCode="AR" term="%22Kwon%2C+Keehwan%22">Kwon, Keehwan</searchLink><br /><searchLink fieldCode="AR" term="%22Chesi%2C+Marta%22">Chesi, Marta</searchLink><br /><searchLink fieldCode="AR" term="%22Smider%2C+Vaughn+V%2E%22">Smider, Vaughn V.</searchLink><br /><searchLink fieldCode="AR" term="%22Salomon%2C+Daniel+R%2E%22">Salomon, Daniel R.</searchLink><br /><searchLink fieldCode="AR" term="%22Jelinek%2C+Diane+F%2E%22">Jelinek, Diane F.</searchLink><br /><searchLink fieldCode="AR" term="%22Kyle%2C+Robert+A%2E%22">Kyle, Robert A.</searchLink><br /><searchLink fieldCode="AR" term="%22Pyles%2C+Richard+B%2E%22">Pyles, Richard B.</searchLink><br /><searchLink fieldCode="AR" term="%22Glass%2C+John+I%2E%22">Glass, John I.</searchLink><br /><searchLink fieldCode="AR" term="%22Ward%2C+Andrew+B%2E%22">Ward, Andrew B.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 2/7/2014, Vol. 343 Issue 6171, p656-661. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Mycoplasma%22">Mycoplasma</searchLink><br /><searchLink fieldCode="DE" term="%22Antigen-antibody+reactions%22">Antigen-antibody reactions</searchLink><br /><searchLink fieldCode="DE" term="%22Crystal+structure%22">Crystal structure</searchLink><br /><searchLink fieldCode="DE" term="%22Membrane+proteins%22">Membrane proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+structure%22">Protein structure</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoglobulin+G%22">Immunoglobulin G</searchLink><br /><searchLink fieldCode="DE" term="%22Antigens%22">Antigens</searchLink>
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  Label: Abstract
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  Data: We report the discovery of a broadly reactive antibody-binding protein (Protein M) from human mycoplasma. The crystal structure of the ectodomain of transmembrane Protein M differs from other known protein structures, as does its mechanism of antibody binding. Protein M binds with high affinity to all types of human and nonhuman immunoglobulin G, predominantly through attachment to the conserved portions of the variable region of the k and l light chains. Protein M blocks antibody-antigen union, likely because of its large C-terminal domain extending over the antibody-combining site, blocking entry to large antigens. Similar to the other immunoglobulin-binding proteins such as Protein A, Protein M as well as its orthologs in other Mycoplasma species could become invaluable reagents in the antibody field. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=94340297
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        Value: 10.1126/science.1246135
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        Text: English
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        PageCount: 6
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      – SubjectFull: Antigen-antibody reactions
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      – SubjectFull: Crystal structure
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      – SubjectFull: Membrane proteins
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      – SubjectFull: Immunoglobulin G
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