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Correlation of Adrenomedullin gene expression in peripheral blood leukocytes with severity of ischemic stroke.

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Title: Correlation of Adrenomedullin gene expression in peripheral blood leukocytes with severity of ischemic stroke.
Authors: Liu, Jia (AUTHOR), Yan, Jun (AUTHOR), Greer, Judith M (AUTHOR), Read, Stephen J (AUTHOR), Henderson, Robert D (AUTHOR), Rose, Stephen E (AUTHOR), Coulthard, Alan (AUTHOR), McCombe, Pamela A (AUTHOR)
Source: International Journal of Neuroscience. Apr2014, Vol. 124 Issue 4, p271-280. 10p.
Subjects: Adrenomedullin, Blood viscosity, Hemodilution, Blood diseases, Position effect (Genetics)
Abstract: Human adrenomedullin (ADM), a 52-amino acid peptide, belongs to the calcitonin/calcitonin gene-related peptide (CGRP)/amylin peptide family. ADM acts as a multifunctional regulatory peptide and is upregulated in response to hypoxia. Previous microarray studies have found increased ADM gene ( ADM) expression in peripheral blood cells of patients with stroke, however, it is unknown if an increased ADM level is correlated with severity of human ischemic stroke. This study investigated ADM expression in peripheral blood leukocytes (PBL) of healthy controls and subjects at day 1, week 1 and week 3 postacute ischemic stroke using rtPCR methodology. We found that ADM expression was significantly upregulated on the first day of stroke compared to the healthy subjects and the disease controls; the levels remained elevated for up to week 3. Further, ADM expression at day 1 was correlated with stroke severity measured by the National Institute of Healthy Stroke Scale (NIHSS), the modified Barthel Index (mBI) and the modified Rankin Scale (mRS). This could indicate that ADM expression level is related to the severity of tissue damage. We suggest that increased ADM expression in PBL after acute ischemic stroke is most likely to indicate that these cells have been subjected to hypoxia and that the magnitude of expression is likely to be related to the volume of hypoxic tissue. Hypoxia can affect lymphocytes function and could affect the immune response to stroke. The correlation of ADM expression level with the measures of stroke severity implicates ADM -a potential blood bio-marker in studies of ischemic stroke. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Correlation of Adrenomedullin gene expression in peripheral blood leukocytes with severity of ischemic stroke.
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  Data: <searchLink fieldCode="AR" term="%22Liu%2C+Jia%22">Liu, Jia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yan%2C+Jun%22">Yan, Jun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Greer%2C+Judith+M%22">Greer, Judith M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Read%2C+Stephen+J%22">Read, Stephen J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Henderson%2C+Robert+D%22">Henderson, Robert D</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rose%2C+Stephen+E%22">Rose, Stephen E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Coulthard%2C+Alan%22">Coulthard, Alan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McCombe%2C+Pamela+A%22">McCombe, Pamela A</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Apr2014, Vol. 124 Issue 4, p271-280. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Adrenomedullin%22">Adrenomedullin</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+viscosity%22">Blood viscosity</searchLink><br /><searchLink fieldCode="DE" term="%22Hemodilution%22">Hemodilution</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+diseases%22">Blood diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Position+effect+%28Genetics%29%22">Position effect (Genetics)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Human adrenomedullin (ADM), a 52-amino acid peptide, belongs to the calcitonin/calcitonin gene-related peptide (CGRP)/amylin peptide family. ADM acts as a multifunctional regulatory peptide and is upregulated in response to hypoxia. Previous microarray studies have found increased ADM gene ( ADM) expression in peripheral blood cells of patients with stroke, however, it is unknown if an increased ADM level is correlated with severity of human ischemic stroke. This study investigated ADM expression in peripheral blood leukocytes (PBL) of healthy controls and subjects at day 1, week 1 and week 3 postacute ischemic stroke using rtPCR methodology. We found that ADM expression was significantly upregulated on the first day of stroke compared to the healthy subjects and the disease controls; the levels remained elevated for up to week 3. Further, ADM expression at day 1 was correlated with stroke severity measured by the National Institute of Healthy Stroke Scale (NIHSS), the modified Barthel Index (mBI) and the modified Rankin Scale (mRS). This could indicate that ADM expression level is related to the severity of tissue damage. We suggest that increased ADM expression in PBL after acute ischemic stroke is most likely to indicate that these cells have been subjected to hypoxia and that the magnitude of expression is likely to be related to the volume of hypoxic tissue. Hypoxia can affect lymphocytes function and could affect the immune response to stroke. The correlation of ADM expression level with the measures of stroke severity implicates ADM -a potential blood bio-marker in studies of ischemic stroke. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3109/00207454.2013.837462
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      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 271
    Subjects:
      – SubjectFull: Adrenomedullin
        Type: general
      – SubjectFull: Blood viscosity
        Type: general
      – SubjectFull: Hemodilution
        Type: general
      – SubjectFull: Blood diseases
        Type: general
      – SubjectFull: Position effect (Genetics)
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      – TitleFull: Correlation of Adrenomedullin gene expression in peripheral blood leukocytes with severity of ischemic stroke.
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            NameFull: Liu, Jia
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              Text: Apr2014
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