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Diffusion tensor imaging in SPG11- and SPG4-linked hereditary spastic paraplegia.

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Title: Diffusion tensor imaging in SPG11- and SPG4-linked hereditary spastic paraplegia.
Authors: Garaci, Francesco (AUTHOR), Toschi, Nicola (AUTHOR), Lanzafame, Simona (AUTHOR), Meschini, Alessandro (AUTHOR), Bertini, Enrico (AUTHOR), Simonetti, Giovanni (AUTHOR), Santorelli, Filippo Maria (AUTHOR), Guerrisi, Maria (AUTHOR), Floris, Roberto (AUTHOR)
Source: International Journal of Neuroscience. Apr2014, Vol. 124 Issue 4, p261-270. 10p.
Subjects: Diffusion tensor imaging, Semiconductor doping, Molecular vibration, Molecular rotation, Leg diseases, Paraplegia
Abstract: The aim of this study was to identify potential diagnostic markers of Hereditary Spastic Paraplegia (HSP). We investigated the white matter features of spastic gait ( SPG)11- and SPG4-linked HSP, using diffusion tensor imaging performed with a 3-Tesla (3T) scanner. We examined four patients with SPG11 mutations, three with SPG4 mutations, and 26 healthy controls. We obtained maps of fractional anisotropy (FA) and mean diffusivity (MD), which we analyzed through both region of interest -based approach and tract-based spatial statistics (TBSS). Compared with healthy controls, SPG11 patients presented increased MD and decreased FA in the semioval centers, frontal and peritrigonal white matter, posterior limb of the internal capsule, and throughout the corpus callosum. Similar alterations were seen in the SPG4 patients at the levels of the semioval centers, the posterior limb of the internal capsule, the left cerebral pedicle, the genu and trunk of the corpus callosum, and the peritrigonal white matter on the left. No MD or FA alterations were observed in the cerebellar white matter. In a direct comparison, white matter alterations were more pronounced and widespread in HSP- SPG11 than in HSP- SPG4 patients. Joint TBSS analysis of all three groups confirmed significant widespread alterations of FA and MD values in the supratentorial white matter. This noninvasive study documented the presence of altered diffusivity in white matter in both forms of HSP, which could represent an important diagnostic marker of HSP. The association of reduced FA and increased MD in this patient population supports the interpretation of HPG as a neurodegenerative disorder. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Diffusion tensor imaging in SPG11- and SPG4-linked hereditary spastic paraplegia.
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  Data: <searchLink fieldCode="AR" term="%22Garaci%2C+Francesco%22">Garaci, Francesco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Toschi%2C+Nicola%22">Toschi, Nicola</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lanzafame%2C+Simona%22">Lanzafame, Simona</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meschini%2C+Alessandro%22">Meschini, Alessandro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bertini%2C+Enrico%22">Bertini, Enrico</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Simonetti%2C+Giovanni%22">Simonetti, Giovanni</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Santorelli%2C+Filippo+Maria%22">Santorelli, Filippo Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guerrisi%2C+Maria%22">Guerrisi, Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Floris%2C+Roberto%22">Floris, Roberto</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Apr2014, Vol. 124 Issue 4, p261-270. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Diffusion+tensor+imaging%22">Diffusion tensor imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Semiconductor+doping%22">Semiconductor doping</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+vibration%22">Molecular vibration</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+rotation%22">Molecular rotation</searchLink><br /><searchLink fieldCode="DE" term="%22Leg+diseases%22">Leg diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Paraplegia%22">Paraplegia</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: The aim of this study was to identify potential diagnostic markers of Hereditary Spastic Paraplegia (HSP). We investigated the white matter features of spastic gait ( SPG)11- and SPG4-linked HSP, using diffusion tensor imaging performed with a 3-Tesla (3T) scanner. We examined four patients with SPG11 mutations, three with SPG4 mutations, and 26 healthy controls. We obtained maps of fractional anisotropy (FA) and mean diffusivity (MD), which we analyzed through both region of interest -based approach and tract-based spatial statistics (TBSS). Compared with healthy controls, SPG11 patients presented increased MD and decreased FA in the semioval centers, frontal and peritrigonal white matter, posterior limb of the internal capsule, and throughout the corpus callosum. Similar alterations were seen in the SPG4 patients at the levels of the semioval centers, the posterior limb of the internal capsule, the left cerebral pedicle, the genu and trunk of the corpus callosum, and the peritrigonal white matter on the left. No MD or FA alterations were observed in the cerebellar white matter. In a direct comparison, white matter alterations were more pronounced and widespread in HSP- SPG11 than in HSP- SPG4 patients. Joint TBSS analysis of all three groups confirmed significant widespread alterations of FA and MD values in the supratentorial white matter. This noninvasive study documented the presence of altered diffusivity in white matter in both forms of HSP, which could represent an important diagnostic marker of HSP. The association of reduced FA and increased MD in this patient population supports the interpretation of HPG as a neurodegenerative disorder. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Semiconductor doping
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      – SubjectFull: Molecular vibration
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      – SubjectFull: Molecular rotation
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      – SubjectFull: Leg diseases
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      – SubjectFull: Paraplegia
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      – TitleFull: Diffusion tensor imaging in SPG11- and SPG4-linked hereditary spastic paraplegia.
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              Text: Apr2014
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