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Characterizing HIV Medication Adherence for Virologic Success Among Individuals Living With HIV/AIDS: Experience With the CNS HIV Antiretroviral Therapy Effects Research ( CHARTER ) Cohort.

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Title: Characterizing HIV Medication Adherence for Virologic Success Among Individuals Living With HIV/AIDS: Experience With the CNS HIV Antiretroviral Therapy Effects Research ( CHARTER ) Cohort.
Authors: Biswas, Bipasha, Spitznagel, Edward, Collier, Ann C., Gelman, Benjamin B., McArthur, Justin C., Morgello, Susan, McCutchan, J. Allen, Clifford, David B., The Charter Group
Source: Journal of HIV/AIDS & Social Services. Jan-Mar2014, Vol. 13 Issue 1, p8-25. 18p.
Subjects: Chi-squared test, Clinical medicine research, Confidence intervals, Mental depression, Drugs, Epidemiology, HIV infections, Health outcome assessment, Patient compliance, Questionnaires, Research funding, Scale analysis (Psychology), Self-evaluation, Statistics, T-test (Statistics), Data analysis, Secondary analysis, Socioeconomic factors, Highly active antiretroviral therapy, Treatment effectiveness, Cross-sectional method, Descriptive statistics, CD4 lymphocyte count
Geographic Terms: California
Abstract: Antiretroviral therapy (ART) has changed HIV-related illness from terminal to chronic by suppressing viral load which results in immunologic and clinical improvement. Success with ART is dependent on optimal adherence, commonly categorized as > 95%. As medication type, class and frequency of use continue to evolve, we assessed adherence levels related to viral suppression. Using a cross-sectional analysis with secondary data(n = 381) from an ongoing multi-site study on impact of ART on the Central Nervous System (CNS), we compared self-reported adherence rates with biological outcomes of HIV-RNA copies/ml, and CD4 cell/mm3. Adherence to ART measures included taking all prescribed medication as directed on schedule and following dietary restrictions. While depression was a barrier to adherence, undetectable viral suppression was achieved at pill adherence percentages lower than 95%. Practice, research and policy implications are discussed in the context of patient-, provider-, and system-level factors influencing adherence to ART. [ABSTRACT FROM PUBLISHER]
Copyright of Journal of HIV/AIDS & Social Services is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Data: Characterizing HIV Medication Adherence for Virologic Success Among Individuals Living With HIV/AIDS: Experience With the CNS HIV Antiretroviral Therapy Effects Research ( CHARTER ) Cohort.
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+HIV%2FAIDS+%26+Social+Services%22">Journal of HIV/AIDS & Social Services</searchLink>. Jan-Mar2014, Vol. 13 Issue 1, p8-25. 18p.
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  Data: <searchLink fieldCode="DE" term="%22California%22">California</searchLink>
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  Data: Antiretroviral therapy (ART) has changed HIV-related illness from terminal to chronic by suppressing viral load which results in immunologic and clinical improvement. Success with ART is dependent on optimal adherence, commonly categorized as > 95%. As medication type, class and frequency of use continue to evolve, we assessed adherence levels related to viral suppression. Using a cross-sectional analysis with secondary data(n = 381) from an ongoing multi-site study on impact of ART on the Central Nervous System (CNS), we compared self-reported adherence rates with biological outcomes of HIV-RNA copies/ml, and CD4 cell/mm3. Adherence to ART measures included taking all prescribed medication as directed on schedule and following dietary restrictions. While depression was a barrier to adherence, undetectable viral suppression was achieved at pill adherence percentages lower than 95%. Practice, research and policy implications are discussed in the context of patient-, provider-, and system-level factors influencing adherence to ART. [ABSTRACT FROM PUBLISHER]
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  Data: <i>Copyright of Journal of HIV/AIDS & Social Services is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1080/15381501.2013.859111
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      – Code: eng
        Text: English
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      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Clinical medicine research
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Drugs
        Type: general
      – SubjectFull: Epidemiology
        Type: general
      – SubjectFull: HIV infections
        Type: general
      – SubjectFull: Health outcome assessment
        Type: general
      – SubjectFull: Patient compliance
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      – SubjectFull: Questionnaires
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      – SubjectFull: Research funding
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      – SubjectFull: Scale analysis (Psychology)
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      – SubjectFull: Self-evaluation
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      – SubjectFull: Statistics
        Type: general
      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: Data analysis
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      – SubjectFull: Secondary analysis
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      – SubjectFull: Socioeconomic factors
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      – SubjectFull: Highly active antiretroviral therapy
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      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Cross-sectional method
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: CD4 lymphocyte count
        Type: general
      – SubjectFull: California
        Type: general
    Titles:
      – TitleFull: Characterizing HIV Medication Adherence for Virologic Success Among Individuals Living With HIV/AIDS: Experience With the CNS HIV Antiretroviral Therapy Effects Research ( CHARTER ) Cohort.
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              Text: Jan-Mar2014
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