Higher baseline international normalized ratio value correlates with higher mortality in intracerebral hemorrhage during warfarin use.
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| Title: | Higher baseline international normalized ratio value correlates with higher mortality in intracerebral hemorrhage during warfarin use. |
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| Authors: | Curtze, S., Strbian, D., Meretoja, A., Putaala, J., Eriksson, H., Haapaniemi, E., Mustanoja, S., Sairanen, T., Satopää, J., Silvennoinen, H., Niemelä, M., Kaste, M., Tatlisumak, T. |
| Source: | European Journal of Neurology. Apr2014, Vol. 21 Issue 4, p616-622. 7p. 3 Charts, 1 Graph. |
| Subjects: | Intracerebral hematoma, Warfarin, Mortality, Multiple regression analysis, Hematoma |
| Abstract: | Background and purpose Intracerebral hemorrhage ( ICH) is the most feared complication of oral anticoagulation ( OAC). Our aim was to investigate the impact of the international normalized ratio ( INR) level on mortality in OAC-associated ICH compared with non- OAC-associated ICH. Methods A retrospective chart review of consecutive ICH patients treated at the Helsinki University Central Hospital from January 2005 to March 2010 ( n = 1013) was performed. An ICH was considered to be OAC-associated if the patient was on warfarin at ICH onset. The association of INR with 3-month mortality was adjusted in a multivariable logistic regression model for factors influencing the crude odds ratios (ORs) in bivariable logistic regression by more than 5%. Results One in eight ICHs was OAC-associated ( n = 132). Of these, 50% had therapeutic INR (2.0-3.0), 7% had INR <2.0 and 43% had high INR (>3.0) on admission. Patients on OAC were older (median 76 vs. 66 years; P < 0.001) with more severe symptoms (median National Institutes of Health Stroke Scale 14 vs. 10; P < 0.001) and larger hematomas (median 11.4 vs. 9.7 ml; P < 0.001) on admission than patients not on OAC. After adjustment for confounders, 3-month mortality in the whole cohort was associated with higher baseline INR (OR 1.06; CI 1.03-1.09 per 0.1 increment). Mortality was higher with both therapeutic (51% at 3 months; OR 3.59; CI 1.50-8.60) and high (61%; OR 5.26; CI 1.94-14.27) INR values compared with non-OAC-associated ICH (29%). Conclusions Patients with OAC-associated ICH had more severe strokes and higher mortality compared with patients with ICH not related to OAC. Higher baseline INR was associated with increased 3-month mortality. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 94914011 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Higher baseline international normalized ratio value correlates with higher mortality in intracerebral hemorrhage during warfarin use. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Curtze%2C+S%2E%22">Curtze, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Strbian%2C+D%2E%22">Strbian, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Meretoja%2C+A%2E%22">Meretoja, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Putaala%2C+J%2E%22">Putaala, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Eriksson%2C+H%2E%22">Eriksson, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Haapaniemi%2C+E%2E%22">Haapaniemi, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Mustanoja%2C+S%2E%22">Mustanoja, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Sairanen%2C+T%2E%22">Sairanen, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Satopää%2C+J%2E%22">Satopää, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Silvennoinen%2C+H%2E%22">Silvennoinen, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Niemelä%2C+M%2E%22">Niemelä, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Kaste%2C+M%2E%22">Kaste, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Tatlisumak%2C+T%2E%22">Tatlisumak, T.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Apr2014, Vol. 21 Issue 4, p616-622. 7p. 3 Charts, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Intracerebral+hematoma%22">Intracerebral hematoma</searchLink><br /><searchLink fieldCode="DE" term="%22Warfarin%22">Warfarin</searchLink><br /><searchLink fieldCode="DE" term="%22Mortality%22">Mortality</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+regression+analysis%22">Multiple regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Hematoma%22">Hematoma</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background and purpose Intracerebral hemorrhage ( ICH) is the most feared complication of oral anticoagulation ( OAC). Our aim was to investigate the impact of the international normalized ratio ( INR) level on mortality in OAC-associated ICH compared with non- OAC-associated ICH. Methods A retrospective chart review of consecutive ICH patients treated at the Helsinki University Central Hospital from January 2005 to March 2010 ( n = 1013) was performed. An ICH was considered to be OAC-associated if the patient was on warfarin at ICH onset. The association of INR with 3-month mortality was adjusted in a multivariable logistic regression model for factors influencing the crude odds ratios (ORs) in bivariable logistic regression by more than 5%. Results One in eight ICHs was OAC-associated ( n = 132). Of these, 50% had therapeutic INR (2.0-3.0), 7% had INR <2.0 and 43% had high INR (>3.0) on admission. Patients on OAC were older (median 76 vs. 66 years; P < 0.001) with more severe symptoms (median National Institutes of Health Stroke Scale 14 vs. 10; P < 0.001) and larger hematomas (median 11.4 vs. 9.7 ml; P < 0.001) on admission than patients not on OAC. After adjustment for confounders, 3-month mortality in the whole cohort was associated with higher baseline INR (OR 1.06; CI 1.03-1.09 per 0.1 increment). Mortality was higher with both therapeutic (51% at 3 months; OR 3.59; CI 1.50-8.60) and high (61%; OR 5.26; CI 1.94-14.27) INR values compared with non-OAC-associated ICH (29%). Conclusions Patients with OAC-associated ICH had more severe strokes and higher mortality compared with patients with ICH not related to OAC. Higher baseline INR was associated with increased 3-month mortality. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ene.12352 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 616 Subjects: – SubjectFull: Intracerebral hematoma Type: general – SubjectFull: Warfarin Type: general – SubjectFull: Mortality Type: general – SubjectFull: Multiple regression analysis Type: general – SubjectFull: Hematoma Type: general Titles: – TitleFull: Higher baseline international normalized ratio value correlates with higher mortality in intracerebral hemorrhage during warfarin use. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Curtze, S. – PersonEntity: Name: NameFull: Strbian, D. – PersonEntity: Name: NameFull: Meretoja, A. – PersonEntity: Name: NameFull: Putaala, J. – PersonEntity: Name: NameFull: Eriksson, H. – PersonEntity: Name: NameFull: Haapaniemi, E. – PersonEntity: Name: NameFull: Mustanoja, S. – PersonEntity: Name: NameFull: Sairanen, T. – PersonEntity: Name: NameFull: Satopää, J. – PersonEntity: Name: NameFull: Silvennoinen, H. – PersonEntity: Name: NameFull: Niemelä, M. – PersonEntity: Name: NameFull: Kaste, M. – PersonEntity: Name: NameFull: Tatlisumak, T. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 13515101 Numbering: – Type: volume Value: 21 – Type: issue Value: 4 Titles: – TitleFull: European Journal of Neurology Type: main |
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