Two Decades After BRCA: Setting Paradigms in Personalized Cancer Care and Prevention.
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| Title: | Two Decades After BRCA: Setting Paradigms in Personalized Cancer Care and Prevention. |
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| Authors: | Couch, Fergus J., Nathanson, Katherine L., Offit, Kenneth |
| Source: | Science (pre-March 2025). 3/28/2014, Vol. 343 Issue 6178, p1466-1470. 5p. |
| Subjects: | BRCA genes, Genetics of breast cancer, Early detection of cancer, Breast cancer treatment, Breast cancer risk factors |
| Abstract: | The cloning of the breast cancer susceptibility genes BRCA1 and BRCA2 nearly two decades ago helped set in motion an avalanche of research exploring how genomic information can be optimally applied to identify and clinically care for individuals with a high risk of developing cancer. Genetic testing for mutations in BRCA1, BRCA2, and other breast cancer susceptibility genes has since proved to be a valuable tool for determining eligibility for enhanced screening and prevention strategies, as well as for identifying patients most likely to benefit from a targeted therapy. Here, we discuss the landscape of inherited mutations and sequence variants in BRCA1 and BRCA2, the complexities of determining disease risk when the pathogenicity of sequence variants is uncertain, and current strategies for clinical management of women who carry BRCA1/2 mutations. [ABSTRACT FROM AUTHOR] |
| Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 95293993 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Two Decades After BRCA: Setting Paradigms in Personalized Cancer Care and Prevention. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Couch%2C+Fergus+J%2E%22">Couch, Fergus J.</searchLink><br /><searchLink fieldCode="AR" term="%22Nathanson%2C+Katherine+L%2E%22">Nathanson, Katherine L.</searchLink><br /><searchLink fieldCode="AR" term="%22Offit%2C+Kenneth%22">Offit, Kenneth</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 3/28/2014, Vol. 343 Issue 6178, p1466-1470. 5p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22BRCA+genes%22">BRCA genes</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics+of+breast+cancer%22">Genetics of breast cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Early+detection+of+cancer%22">Early detection of cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Breast+cancer+treatment%22">Breast cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Breast+cancer+risk+factors%22">Breast cancer risk factors</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The cloning of the breast cancer susceptibility genes BRCA1 and BRCA2 nearly two decades ago helped set in motion an avalanche of research exploring how genomic information can be optimally applied to identify and clinically care for individuals with a high risk of developing cancer. Genetic testing for mutations in BRCA1, BRCA2, and other breast cancer susceptibility genes has since proved to be a valuable tool for determining eligibility for enhanced screening and prevention strategies, as well as for identifying patients most likely to benefit from a targeted therapy. Here, we discuss the landscape of inherited mutations and sequence variants in BRCA1 and BRCA2, the complexities of determining disease risk when the pathogenicity of sequence variants is uncertain, and current strategies for clinical management of women who carry BRCA1/2 mutations. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=95293993 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1126/science.1251827 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 1466 Subjects: – SubjectFull: BRCA genes Type: general – SubjectFull: Genetics of breast cancer Type: general – SubjectFull: Early detection of cancer Type: general – SubjectFull: Breast cancer treatment Type: general – SubjectFull: Breast cancer risk factors Type: general Titles: – TitleFull: Two Decades After BRCA: Setting Paradigms in Personalized Cancer Care and Prevention. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Couch, Fergus J. – PersonEntity: Name: NameFull: Nathanson, Katherine L. – PersonEntity: Name: NameFull: Offit, Kenneth IsPartOfRelationships: – BibEntity: Dates: – D: 28 M: 03 Text: 3/28/2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 00368075 Numbering: – Type: volume Value: 343 – Type: issue Value: 6178 Titles: – TitleFull: Science (pre-March 2025) Type: main |
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