View in EDS HTML Full Text PDF Full Text

Medication adherence in a comparative effectiveness trial for bipolar disorder.

Saved in:
Bibliographic Details
Title: Medication adherence in a comparative effectiveness trial for bipolar disorder.
Authors: Sylvia, L. G., Reilly‐Harrington, N. A., Leon, A. C., Kansky, C. I., Calabrese, J. R., Bowden, C. L., Ketter, T. A., Friedman, E. S., Iosifescu, D. V., Thase, M. E., Ostacher, M. J., Keyes, M., Rabideau, D., Nierenberg, A. A.
Source: Acta Psychiatrica Scandinavica. May2014, Vol. 129 Issue 5, p359-365. 7p.
Subjects: Therapeutics, Bipolar disorder, Quality of life, Blood plasma, Drug therapy, Mental depression
Abstract: Objective Psychopharmacology remains the foundation of treatment for bipolar disorder, but medication adherence in this population is low (range 20-64%). We examined medication adherence in a multisite, comparative effectiveness study of lithium. Method The Lithium Moderate Dose Use Study (Li TMUS) was a 6-month, six-site, randomized effectiveness trial of adjunctive moderate dose lithium therapy compared with optimized treatment in adult out-patients with bipolar I or II disorder ( N = 283). Medication adherence was measured at each study visit with the Tablet Routine Questionnaire. Results We found that 4.50% of participants reported missing at least 30% of their medications in the past week at baseline and non-adherence remained low throughout the trial (<7%). Poor medication adherence was associated with more manic symptoms and side-effects as well as lower lithium serum levels at mid- and post-treatment, but not with poor quality of life, overall severity of illness, or depressive symptoms. Conclusion Participants in Li TMUS were highly adherent with taking their medications. The lack of association with possible predictors of adherence, such as depression and quality of life, could be explained by the limited variance or other factors as well as by not using an objective measure of adherence. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 95576106
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Medication adherence in a comparative effectiveness trial for bipolar disorder.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sylvia%2C+L%2E+G%2E%22&quot;&gt;Sylvia, L. G.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Reilly‐Harrington%2C+N%2E+A%2E%22&quot;&gt;Reilly‐Harrington, N. A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Leon%2C+A%2E+C%2E%22&quot;&gt;Leon, A. C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kansky%2C+C%2E+I%2E%22&quot;&gt;Kansky, C. I.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Calabrese%2C+J%2E+R%2E%22&quot;&gt;Calabrese, J. R.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bowden%2C+C%2E+L%2E%22&quot;&gt;Bowden, C. L.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ketter%2C+T%2E+A%2E%22&quot;&gt;Ketter, T. A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Friedman%2C+E%2E+S%2E%22&quot;&gt;Friedman, E. S.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Iosifescu%2C+D%2E+V%2E%22&quot;&gt;Iosifescu, D. V.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Thase%2C+M%2E+E%2E%22&quot;&gt;Thase, M. E.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ostacher%2C+M%2E+J%2E%22&quot;&gt;Ostacher, M. J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Keyes%2C+M%2E%22&quot;&gt;Keyes, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rabideau%2C+D%2E%22&quot;&gt;Rabideau, D.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nierenberg%2C+A%2E+A%2E%22&quot;&gt;Nierenberg, A. A.&lt;/searchLink&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Acta+Psychiatrica+Scandinavica%22&quot;&gt;Acta Psychiatrica Scandinavica&lt;/searchLink&gt;. May2014, Vol. 129 Issue 5, p359-365. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Therapeutics%22&quot;&gt;Therapeutics&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bipolar+disorder%22&quot;&gt;Bipolar disorder&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Quality+of+life%22&quot;&gt;Quality of life&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Blood+plasma%22&quot;&gt;Blood plasma&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Drug+therapy%22&quot;&gt;Drug therapy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mental+depression%22&quot;&gt;Mental depression&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective Psychopharmacology remains the foundation of treatment for bipolar disorder, but medication adherence in this population is low (range 20-64%). We examined medication adherence in a multisite, comparative effectiveness study of lithium. Method The Lithium Moderate Dose Use Study (Li TMUS) was a 6-month, six-site, randomized effectiveness trial of adjunctive moderate dose lithium therapy compared with optimized treatment in adult out-patients with bipolar I or II disorder ( N = 283). Medication adherence was measured at each study visit with the Tablet Routine Questionnaire. Results We found that 4.50% of participants reported missing at least 30% of their medications in the past week at baseline and non-adherence remained low throughout the trial (&lt;7%). Poor medication adherence was associated with more manic symptoms and side-effects as well as lower lithium serum levels at mid- and post-treatment, but not with poor quality of life, overall severity of illness, or depressive symptoms. Conclusion Participants in Li TMUS were highly adherent with taking their medications. The lack of association with possible predictors of adherence, such as depression and quality of life, could be explained by the limited variance or other factors as well as by not using an objective measure of adherence. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=95576106
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/acps.12202
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 359
    Subjects:
      – SubjectFull: Therapeutics
        Type: general
      – SubjectFull: Bipolar disorder
        Type: general
      – SubjectFull: Quality of life
        Type: general
      – SubjectFull: Blood plasma
        Type: general
      – SubjectFull: Drug therapy
        Type: general
      – SubjectFull: Mental depression
        Type: general
    Titles:
      – TitleFull: Medication adherence in a comparative effectiveness trial for bipolar disorder.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Sylvia, L. G.
      – PersonEntity:
          Name:
            NameFull: Reilly‐Harrington, N. A.
      – PersonEntity:
          Name:
            NameFull: Leon, A. C.
      – PersonEntity:
          Name:
            NameFull: Kansky, C. I.
      – PersonEntity:
          Name:
            NameFull: Calabrese, J. R.
      – PersonEntity:
          Name:
            NameFull: Bowden, C. L.
      – PersonEntity:
          Name:
            NameFull: Ketter, T. A.
      – PersonEntity:
          Name:
            NameFull: Friedman, E. S.
      – PersonEntity:
          Name:
            NameFull: Iosifescu, D. V.
      – PersonEntity:
          Name:
            NameFull: Thase, M. E.
      – PersonEntity:
          Name:
            NameFull: Ostacher, M. J.
      – PersonEntity:
          Name:
            NameFull: Keyes, M.
      – PersonEntity:
          Name:
            NameFull: Rabideau, D.
      – PersonEntity:
          Name:
            NameFull: Nierenberg, A. A.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2014
              Type: published
              Y: 2014
          Identifiers:
            – Type: issn-print
              Value: 0001690X
          Numbering:
            – Type: volume
              Value: 129
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Acta Psychiatrica Scandinavica
              Type: main
ResultId 1