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Clinical implications of predominant polarity and the polarity index in bipolar disorder: a naturalistic study.

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Title: Clinical implications of predominant polarity and the polarity index in bipolar disorder: a naturalistic study.
Authors: Popovic, D., Torrent, C., Goikolea, J. M., Cruz, N., Sánchez‐Moreno, J., González‐Pinto, A., Vieta, E.
Source: Acta Psychiatrica Scandinavica. May2014, Vol. 129 Issue 5, p366-374. 9p.
Subjects: Bipolar disorder, Therapeutics, Mental depression, Affective disorders, Antipsychotic agents, Suicidal behavior
Abstract: Objective Predominant polarity ( PP) is an important variable in maintenance treatment of bipolar disorder ( BD). This study aimed at determining the role of polarity index ( PI), a metric indicating antimanic versus antidepressive prophylactic potential of drugs, in clinical decision-making. Method Two hundred and fifty-seven of 604 (43%) of patients with BD- I or II fulfilled criteria for manic ( MPP) or depressive PP ( DPP). The PI, representing the ratio of number needed to treat ( NNT) for depression prevention to NNT for mania prevention, was calculated for patients' current treatment. MPP and DPP groups were compared regarding sociodemographic, clinical and therapeutic characteristics. Results One hundred and forty-three patients (55.6%) fulfilled criteria for DPP and 114 (44.4%) for MPP. Total PI, Antipsychotics' PI, and mood stabilizers PI were higher, indicating a stronger antimanic action, in MPP. MPP presented higher prevalence of BD- I, male gender, younger age, age at onset and at first hospitalization, more hospitalizations, primary substance misuse, and psychotic symptoms. DP correlated with BD- II, depressive onset, primary life events, melancholia, and suicide attempts. Conclusion The results confirm the usefulness of the PI. In this large sample, clinical differences among these groups justify differential treatment approach. The PI appears to be a useful operationalization of what clinicians do for maintenance therapy in BD. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Clinical implications of predominant polarity and the polarity index in bipolar disorder: a naturalistic study.
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  Data: <searchLink fieldCode="AR" term="%22Popovic%2C+D%2E%22">Popovic, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Torrent%2C+C%2E%22">Torrent, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Goikolea%2C+J%2E+M%2E%22">Goikolea, J. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Cruz%2C+N%2E%22">Cruz, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Sánchez‐Moreno%2C+J%2E%22">Sánchez‐Moreno, J.</searchLink><br /><searchLink fieldCode="AR" term="%22González‐Pinto%2C+A%2E%22">González‐Pinto, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Vieta%2C+E%2E%22">Vieta, E.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. May2014, Vol. 129 Issue 5, p366-374. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Affective+disorders%22">Affective disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Antipsychotic+agents%22">Antipsychotic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Suicidal+behavior%22">Suicidal behavior</searchLink>
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  Label: Abstract
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  Data: Objective Predominant polarity ( PP) is an important variable in maintenance treatment of bipolar disorder ( BD). This study aimed at determining the role of polarity index ( PI), a metric indicating antimanic versus antidepressive prophylactic potential of drugs, in clinical decision-making. Method Two hundred and fifty-seven of 604 (43%) of patients with BD- I or II fulfilled criteria for manic ( MPP) or depressive PP ( DPP). The PI, representing the ratio of number needed to treat ( NNT) for depression prevention to NNT for mania prevention, was calculated for patients' current treatment. MPP and DPP groups were compared regarding sociodemographic, clinical and therapeutic characteristics. Results One hundred and forty-three patients (55.6%) fulfilled criteria for DPP and 114 (44.4%) for MPP. Total PI, Antipsychotics' PI, and mood stabilizers PI were higher, indicating a stronger antimanic action, in MPP. MPP presented higher prevalence of BD- I, male gender, younger age, age at onset and at first hospitalization, more hospitalizations, primary substance misuse, and psychotic symptoms. DP correlated with BD- II, depressive onset, primary life events, melancholia, and suicide attempts. Conclusion The results confirm the usefulness of the PI. In this large sample, clinical differences among these groups justify differential treatment approach. The PI appears to be a useful operationalization of what clinicians do for maintenance therapy in BD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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