View in EDS PDF Full Text

Erythromycin pretreatment induces tolerance against focal cerebral ischemia through up-regulation of nNOS but not down-regulation of HIF-1α in rats.

Saved in:
Bibliographic Details
Title: Erythromycin pretreatment induces tolerance against focal cerebral ischemia through up-regulation of nNOS but not down-regulation of HIF-1α in rats.
Authors: Lu, Wei-cheng, Li, Guang-yu, Xie, Hui, Qiu, Bo, Yang, Ri-miao, Guo, Zong-ze
Source: Neurological Sciences. May2014, Vol. 35 Issue 5, p687-693. 7p.
Subjects: Erythromycin, Cerebral ischemia, Laboratory rats, Nitric-oxide synthases, Hypoxia-inducible factors, Neurological disorders
Abstract: The purpose of this study was to determine whether the antibiotic erythromycin induces tolerance against focal cerebral ischemia, and the possible underlying mechanism including the involvement of neuronal nitric oxide synthase (nNOS) and hypoxia-inducible factor-1α (HIF-1α). In rat focal cerebral ischemia models, we found that erythromycin preconditioning could significantly decrease the cerebral infarct volume and brain edema. Meanwhile, the neurological deficits from day 4 through 7 after surgery were also remarkably decreased after erythromycin preconditioning. Moreover, erythromycin preconditioning induced significantly increased nNOS levels and decreased HIF-1α levels in both mRNA and protein expression. This study for the first time indicated that erythromycin preconditioning could induce focal brain ischemic tolerance and attenuate brain injury of subsequent transient focal cerebral ischemia. The potential mechanism may be due to up-regulation of nNOS, but the HIF-1α system was not involved. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 95695307
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Erythromycin pretreatment induces tolerance against focal cerebral ischemia through up-regulation of nNOS but not down-regulation of HIF-1α in rats.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Lu%2C+Wei-cheng%22">Lu, Wei-cheng</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Guang-yu%22">Li, Guang-yu</searchLink><br /><searchLink fieldCode="AR" term="%22Xie%2C+Hui%22">Xie, Hui</searchLink><br /><searchLink fieldCode="AR" term="%22Qiu%2C+Bo%22">Qiu, Bo</searchLink><br /><searchLink fieldCode="AR" term="%22Yang%2C+Ri-miao%22">Yang, Ri-miao</searchLink><br /><searchLink fieldCode="AR" term="%22Guo%2C+Zong-ze%22">Guo, Zong-ze</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. May2014, Vol. 35 Issue 5, p687-693. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Erythromycin%22">Erythromycin</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+ischemia%22">Cerebral ischemia</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink><br /><searchLink fieldCode="DE" term="%22Nitric-oxide+synthases%22">Nitric-oxide synthases</searchLink><br /><searchLink fieldCode="DE" term="%22Hypoxia-inducible+factors%22">Hypoxia-inducible factors</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+disorders%22">Neurological disorders</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The purpose of this study was to determine whether the antibiotic erythromycin induces tolerance against focal cerebral ischemia, and the possible underlying mechanism including the involvement of neuronal nitric oxide synthase (nNOS) and hypoxia-inducible factor-1α (HIF-1α). In rat focal cerebral ischemia models, we found that erythromycin preconditioning could significantly decrease the cerebral infarct volume and brain edema. Meanwhile, the neurological deficits from day 4 through 7 after surgery were also remarkably decreased after erythromycin preconditioning. Moreover, erythromycin preconditioning induced significantly increased nNOS levels and decreased HIF-1α levels in both mRNA and protein expression. This study for the first time indicated that erythromycin preconditioning could induce focal brain ischemic tolerance and attenuate brain injury of subsequent transient focal cerebral ischemia. The potential mechanism may be due to up-regulation of nNOS, but the HIF-1α system was not involved. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=95695307
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10072-013-1584-5
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 687
    Subjects:
      – SubjectFull: Erythromycin
        Type: general
      – SubjectFull: Cerebral ischemia
        Type: general
      – SubjectFull: Laboratory rats
        Type: general
      – SubjectFull: Nitric-oxide synthases
        Type: general
      – SubjectFull: Hypoxia-inducible factors
        Type: general
      – SubjectFull: Neurological disorders
        Type: general
    Titles:
      – TitleFull: Erythromycin pretreatment induces tolerance against focal cerebral ischemia through up-regulation of nNOS but not down-regulation of HIF-1α in rats.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Lu, Wei-cheng
      – PersonEntity:
          Name:
            NameFull: Li, Guang-yu
      – PersonEntity:
          Name:
            NameFull: Xie, Hui
      – PersonEntity:
          Name:
            NameFull: Qiu, Bo
      – PersonEntity:
          Name:
            NameFull: Yang, Ri-miao
      – PersonEntity:
          Name:
            NameFull: Guo, Zong-ze
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2014
              Type: published
              Y: 2014
          Identifiers:
            – Type: issn-print
              Value: 15901874
          Numbering:
            – Type: volume
              Value: 35
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Neurological Sciences
              Type: main
ResultId 1