Effects of Isoflurane on the Auditory Brainstem Responses and Middle Latency Responses of Rats.
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| Title: | Effects of Isoflurane on the Auditory Brainstem Responses and Middle Latency Responses of Rats. |
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| Authors: | Santarelli, Rosamaria, Arslan, Edoardo, Carraro, Luigi, Conti, Guido, Capello, Massimo, Plourde, Gilles |
| Source: | Acta Oto-Laryngologica. Mar2003, Vol. 123 Issue 2, p176. 6p. |
| Subjects: | Hearing, Isoflurane |
| Abstract: | Objective-To evaluate the effects of a volatile anesthetic, isoflurane, on auditory brainstem responses (ABRs) and middle latency responses (MLRs) recorded in rats. Material and Methods-ABRs and MLRs evoked by click stimuli were simultaneously recorded in eight rats in the awake condition and during anesthesia with isoflurane at clinically relevant concentrations. Results-Vertex-recorded ABRs showed a significant increase in the latency of waves I-IV during anesthesia and the latency changes appeared to be significantly related to the isoflurane concentration. The I-IV interval also appeared to be significantly increased in comparison to the awake condition, while minor changes in ABR amplitudes were induced by isoflurane. MLRs, which were recorded by means of epidural electrodes implanted over the auditory cortex, appeared to be attenuated in amplitude and increased in latency during anesthesia. Only latency changes appeared to be significantly related to the isoflurane concentration. Moreover, "bursts" of high amplitude MLRs were observed during anesthesia at each concentration. Conclusion-The present findings indicate that both ABR and MLR latencies are increased by isoflurane in a concentration-dependent manner, whilst the anesthetic-induced attenuation in amplitude does not appear to be related to the isoflurane concentration. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 9594579 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of Isoflurane on the Auditory Brainstem Responses and Middle Latency Responses of Rats. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Santarelli%2C+Rosamaria%22">Santarelli, Rosamaria</searchLink><br /><searchLink fieldCode="AR" term="%22Arslan%2C+Edoardo%22">Arslan, Edoardo</searchLink><br /><searchLink fieldCode="AR" term="%22Carraro%2C+Luigi%22">Carraro, Luigi</searchLink><br /><searchLink fieldCode="AR" term="%22Conti%2C+Guido%22">Conti, Guido</searchLink><br /><searchLink fieldCode="AR" term="%22Capello%2C+Massimo%22">Capello, Massimo</searchLink><br /><searchLink fieldCode="AR" term="%22Plourde%2C+Gilles%22">Plourde, Gilles</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Mar2003, Vol. 123 Issue 2, p176. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Hearing%22">Hearing</searchLink><br /><searchLink fieldCode="DE" term="%22Isoflurane%22">Isoflurane</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective-To evaluate the effects of a volatile anesthetic, isoflurane, on auditory brainstem responses (ABRs) and middle latency responses (MLRs) recorded in rats. Material and Methods-ABRs and MLRs evoked by click stimuli were simultaneously recorded in eight rats in the awake condition and during anesthesia with isoflurane at clinically relevant concentrations. Results-Vertex-recorded ABRs showed a significant increase in the latency of waves I-IV during anesthesia and the latency changes appeared to be significantly related to the isoflurane concentration. The I-IV interval also appeared to be significantly increased in comparison to the awake condition, while minor changes in ABR amplitudes were induced by isoflurane. MLRs, which were recorded by means of epidural electrodes implanted over the auditory cortex, appeared to be attenuated in amplitude and increased in latency during anesthesia. Only latency changes appeared to be significantly related to the isoflurane concentration. Moreover, "bursts" of high amplitude MLRs were observed during anesthesia at each concentration. Conclusion-The present findings indicate that both ABR and MLR latencies are increased by isoflurane in a concentration-dependent manner, whilst the anesthetic-induced attenuation in amplitude does not appear to be related to the isoflurane concentration. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=9594579 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/0036554021000028108 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 176 Subjects: – SubjectFull: Hearing Type: general – SubjectFull: Isoflurane Type: general Titles: – TitleFull: Effects of Isoflurane on the Auditory Brainstem Responses and Middle Latency Responses of Rats. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Santarelli, Rosamaria – PersonEntity: Name: NameFull: Arslan, Edoardo – PersonEntity: Name: NameFull: Carraro, Luigi – PersonEntity: Name: NameFull: Conti, Guido – PersonEntity: Name: NameFull: Capello, Massimo – PersonEntity: Name: NameFull: Plourde, Gilles IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2003 Type: published Y: 2003 Identifiers: – Type: issn-print Value: 00016489 Numbering: – Type: volume Value: 123 – Type: issue Value: 2 Titles: – TitleFull: Acta Oto-Laryngologica Type: main |
| ResultId | 1 |
