View in EDS HTML Full Text PDF Full Text

Statin use and peripheral sensory perception: A pilot study.

Saved in:
Bibliographic Details
Title: Statin use and peripheral sensory perception: A pilot study.
Authors: West, Brenton (AUTHOR), Williams, Cylie M. (AUTHOR), Jilbert, Elise (AUTHOR), James, Alicia M. (AUTHOR), Haines, Terry P. (AUTHOR)
Source: Somatosensory & Motor Research. Jun2014, Vol. 31 Issue 2, p57-61. 5p. 2 Color Photographs, 2 Charts.
Subjects: Peripheral neuropathy, Health risk assessment, Statins (Cardiovascular agents), Diabetes risk factors, Neurological errors
Abstract: Objectives. Peripheral sensory neuropathy is a neurological deficit resulting in decreased detection of sensation through the peripheral nervous system. Peripheral sensory neuropathy is commonly diagnosed with the use of a monofilament and either a tuning fork or neurothesiometer. Statins are a widely used medication and there has been some debate of association with their use and peripheral sensory neuropathy. This pilot study aimed to test the sensory perception of participants with long-term statin use and compare these results to their peers who were not taking statins. Methods. Thirty participants were recruited and equally divided into a statin and non-statin group. Healthy participants were screened by their medical and medication history, Australian Type 2 Diabetes Risk assessment, and random blood glucose level. An assessor who was blinded to the participant group conducted sensory assessments using a 10 g monofilament and neurothesiometer. Results. There was no difference in monofilament testing results between the groups. The statin group was less sensate at the styloid process ( p = 0.031) and medial malleolus ( p = 0.003) than the control group. Results at the hallux were not statistically significant ( p = 0.183). Conclusion. This result is suggestive of a potential association between long-term statin use and a decrease in peripheral sensory perception. This may be because of peripheral sensory neuropathy. Limitations such as consideration of participant height, participant numbers, and inability to analyze results against statin groups are reported. As statins are a life-saving medication, careful consideration should be applied to these results and further research be conducted to determine if these results are applicable to larger populations. [ABSTRACT FROM AUTHOR]
Copyright of Somatosensory & Motor Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 96094634
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Statin use and peripheral sensory perception: A pilot study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22West%2C+Brenton%22">West, Brenton</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Williams%2C+Cylie+M%2E%22">Williams, Cylie M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jilbert%2C+Elise%22">Jilbert, Elise</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22James%2C+Alicia+M%2E%22">James, Alicia M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Haines%2C+Terry+P%2E%22">Haines, Terry P.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Somatosensory+%26+Motor+Research%22">Somatosensory & Motor Research</searchLink>. Jun2014, Vol. 31 Issue 2, p57-61. 5p. 2 Color Photographs, 2 Charts.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Peripheral+neuropathy%22">Peripheral neuropathy</searchLink><br /><searchLink fieldCode="DE" term="%22Health+risk+assessment%22">Health risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Statins+%28Cardiovascular+agents%29%22">Statins (Cardiovascular agents)</searchLink><br /><searchLink fieldCode="DE" term="%22Diabetes+risk+factors%22">Diabetes risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+errors%22">Neurological errors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives. Peripheral sensory neuropathy is a neurological deficit resulting in decreased detection of sensation through the peripheral nervous system. Peripheral sensory neuropathy is commonly diagnosed with the use of a monofilament and either a tuning fork or neurothesiometer. Statins are a widely used medication and there has been some debate of association with their use and peripheral sensory neuropathy. This pilot study aimed to test the sensory perception of participants with long-term statin use and compare these results to their peers who were not taking statins. Methods. Thirty participants were recruited and equally divided into a statin and non-statin group. Healthy participants were screened by their medical and medication history, Australian Type 2 Diabetes Risk assessment, and random blood glucose level. An assessor who was blinded to the participant group conducted sensory assessments using a 10 g monofilament and neurothesiometer. Results. There was no difference in monofilament testing results between the groups. The statin group was less sensate at the styloid process ( p = 0.031) and medial malleolus ( p = 0.003) than the control group. Results at the hallux were not statistically significant ( p = 0.183). Conclusion. This result is suggestive of a potential association between long-term statin use and a decrease in peripheral sensory perception. This may be because of peripheral sensory neuropathy. Limitations such as consideration of participant height, participant numbers, and inability to analyze results against statin groups are reported. As statins are a life-saving medication, careful consideration should be applied to these results and further research be conducted to determine if these results are applicable to larger populations. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Somatosensory & Motor Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=96094634
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3109/08990220.2013.840281
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 57
    Subjects:
      – SubjectFull: Peripheral neuropathy
        Type: general
      – SubjectFull: Health risk assessment
        Type: general
      – SubjectFull: Statins (Cardiovascular agents)
        Type: general
      – SubjectFull: Diabetes risk factors
        Type: general
      – SubjectFull: Neurological errors
        Type: general
    Titles:
      – TitleFull: Statin use and peripheral sensory perception: A pilot study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: West, Brenton
      – PersonEntity:
          Name:
            NameFull: Williams, Cylie M.
      – PersonEntity:
          Name:
            NameFull: Jilbert, Elise
      – PersonEntity:
          Name:
            NameFull: James, Alicia M.
      – PersonEntity:
          Name:
            NameFull: Haines, Terry P.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2014
              Type: published
              Y: 2014
          Identifiers:
            – Type: issn-print
              Value: 08990220
          Numbering:
            – Type: volume
              Value: 31
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Somatosensory & Motor Research
              Type: main
ResultId 1