Neuropathological changes in the substantia nigra in schizophrenia but not depression.
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| Title: | Neuropathological changes in the substantia nigra in schizophrenia but not depression. |
|---|---|
| Authors: | Williams, M., Galvin, K., O'Sullivan, B., MacDonald, C., Ching, E., Turkheimer, F., Howes, O., Pearce, R., Hirsch, S., Maier, M. |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Jun2014, Vol. 264 Issue 4, p285-296. 12p. |
| Subjects: | Schizophrenia treatment, Neurological disorders, Substantia nigra, Physiological effects of dopamine, Cytoarchitectonics, Symptoms |
| Abstract: | Schizophrenia is a chronic, disabling neuropsychiatric disorder characterised by positive, negative and cognitive symptoms. The aetiology is not known, although genetic, imaging and pathological studies have implicated both neurodevelopmental and neurodegenerative processes. The substantia nigra is a basal ganglia nucleus responsible for the production of dopamine and projection of dopaminergic neurons to the striatum. The substantia nigra is implicated in schizophrenia as dopamine has been heavily implicated in the dopamine hypothesis of schizophrenia and the prevalent psychotic symptoms and the monoamine theory of depression, and is a target for the development of new therapies. Studies into the major dopamine delivery pathways in the brain will therefore provide a strong base in improving knowledge of these psychiatric disorders. This post-mortem study examines the cytoarchitecture of dopaminergic neurons of the substantia nigra in schizophrenia ( n = 12) and depression ( n = 13) compared to matched controls ( n = 13). Measures of nucleolar volume, nuclear length and nuclear area were taken in patients with chronic schizophrenia and major depressive disorder against matched controls. Astrocyte density was decreased in schizophrenia compared to controls ( p = 0.030), with no change in oligodendrocyte density observed. Significantly increased nuclear cross-sectional area ( p = 0.017) and length ( p = 0.021), and increased nucleolar volume ( p = 0.037) in dopaminergic neurons were observed in schizophrenia patients compared with controls, suggesting nuclear pleomorphic changes. No changes were observed in depression cases compared to control group. These changes may reflect pathological alterations in gene expression, neuronal structure and function in schizophrenia. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 96201937 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Neuropathological changes in the substantia nigra in schizophrenia but not depression. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Williams%2C+M%2E%22">Williams, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Galvin%2C+K%2E%22">Galvin, K.</searchLink><br /><searchLink fieldCode="AR" term="%22O'Sullivan%2C+B%2E%22">O'Sullivan, B.</searchLink><br /><searchLink fieldCode="AR" term="%22MacDonald%2C+C%2E%22">MacDonald, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Ching%2C+E%2E%22">Ching, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Turkheimer%2C+F%2E%22">Turkheimer, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Howes%2C+O%2E%22">Howes, O.</searchLink><br /><searchLink fieldCode="AR" term="%22Pearce%2C+R%2E%22">Pearce, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Hirsch%2C+S%2E%22">Hirsch, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Maier%2C+M%2E%22">Maier, M.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Jun2014, Vol. 264 Issue 4, p285-296. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Schizophrenia+treatment%22">Schizophrenia treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+disorders%22">Neurological disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Substantia+nigra%22">Substantia nigra</searchLink><br /><searchLink fieldCode="DE" term="%22Physiological+effects+of+dopamine%22">Physiological effects of dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Cytoarchitectonics%22">Cytoarchitectonics</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Schizophrenia is a chronic, disabling neuropsychiatric disorder characterised by positive, negative and cognitive symptoms. The aetiology is not known, although genetic, imaging and pathological studies have implicated both neurodevelopmental and neurodegenerative processes. The substantia nigra is a basal ganglia nucleus responsible for the production of dopamine and projection of dopaminergic neurons to the striatum. The substantia nigra is implicated in schizophrenia as dopamine has been heavily implicated in the dopamine hypothesis of schizophrenia and the prevalent psychotic symptoms and the monoamine theory of depression, and is a target for the development of new therapies. Studies into the major dopamine delivery pathways in the brain will therefore provide a strong base in improving knowledge of these psychiatric disorders. This post-mortem study examines the cytoarchitecture of dopaminergic neurons of the substantia nigra in schizophrenia ( n = 12) and depression ( n = 13) compared to matched controls ( n = 13). Measures of nucleolar volume, nuclear length and nuclear area were taken in patients with chronic schizophrenia and major depressive disorder against matched controls. Astrocyte density was decreased in schizophrenia compared to controls ( p = 0.030), with no change in oligodendrocyte density observed. Significantly increased nuclear cross-sectional area ( p = 0.017) and length ( p = 0.021), and increased nucleolar volume ( p = 0.037) in dopaminergic neurons were observed in schizophrenia patients compared with controls, suggesting nuclear pleomorphic changes. No changes were observed in depression cases compared to control group. These changes may reflect pathological alterations in gene expression, neuronal structure and function in schizophrenia. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-013-0479-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 285 Subjects: – SubjectFull: Schizophrenia treatment Type: general – SubjectFull: Neurological disorders Type: general – SubjectFull: Substantia nigra Type: general – SubjectFull: Physiological effects of dopamine Type: general – SubjectFull: Cytoarchitectonics Type: general – SubjectFull: Symptoms Type: general Titles: – TitleFull: Neuropathological changes in the substantia nigra in schizophrenia but not depression. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Williams, M. – PersonEntity: Name: NameFull: Galvin, K. – PersonEntity: Name: NameFull: O'Sullivan, B. – PersonEntity: Name: NameFull: MacDonald, C. – PersonEntity: Name: NameFull: Ching, E. – PersonEntity: Name: NameFull: Turkheimer, F. – PersonEntity: Name: NameFull: Howes, O. – PersonEntity: Name: NameFull: Pearce, R. – PersonEntity: Name: NameFull: Hirsch, S. – PersonEntity: Name: NameFull: Maier, M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 264 – Type: issue Value: 4 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
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