Iron deposits in post-mortem brains of patients with neurodegenerative and cerebrovascular diseases: a semi-quantitative 7.0 T magnetic resonance imaging study.
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| Title: | Iron deposits in post-mortem brains of patients with neurodegenerative and cerebrovascular diseases: a semi-quantitative 7.0 T magnetic resonance imaging study. |
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| Authors: | De Reuck, J. L., Deramecourt, V., Auger, F., Durieux, N., Cordonnier, C., Devos, D., Defebvre, L., Moreau, C., Caparros ‐ Lefebvre, D., Leys, D., Maurage, C. A., Pasquier, F., Bordet, R. |
| Source: | European Journal of Neurology. Jul2014, Vol. 21 Issue 7, p1026-1031. 6p. |
| Subjects: | Iron in the body, Neurodegeneration, Magnetic resonance imaging, Alzheimer's patients, Vascular dementia, Patients |
| Abstract: | Background and purpose Accumulation of iron (Fe) is often detected in brains of people suffering from neurodegenerative diseases. However, no studies have compared the Fe load between these disease entities. The present study investigates by T2*-weighted gradient-echo 7.0 T magnetic resonance imaging ( MRI) the Fe content in post-mortem brains with different neurodegenerative and cerebrovascular diseases. Methods One hundred and fifty-two post-mortem brains, composed of 46 with Alzheimer's disease ( AD), 37 with frontotemporal lobar degeneration ( FTLD), 11 with amyotrophic lateral sclerosis, 13 with Lewy body disease, 14 with progressive supranuclear palsy, 16 with vascular dementia (VaD) and 15 controls without a brain disease, were examined. The Fe load was determined semi-quantitatively on T2*-weighted MRI serial brain sections in the claustrum, caudate nucleus, putamen, globus pallidus, thalamus, subthalamic nucleus, hippocampus, mamillary body, lateral geniculate body, red nucleus, substantia nigra and dentate nucleus. The disease diagnosis was made on subsequent neuropathological examination. Results The Fe load was significantly increased in the claustrum, caudate nucleus and putamen of FTLD brains and to a lesser degree in the globus pallidus, thalamus and subthalamic nucleus. In the other neurodegenerative diseases no Fe accumulation was observed, except for a mild increase in the caudate nucleus of AD brains. In VaD brains no Fe increase was detected. Conclusions Only FTLD displays a significant Fe load, suggesting that impaired Fe homeostasis plays an important role in the pathogenesis of this heterogeneous disease entity. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 96424488 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Iron deposits in post-mortem brains of patients with neurodegenerative and cerebrovascular diseases: a semi-quantitative 7.0 T magnetic resonance imaging study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22De+Reuck%2C+J%2E+L%2E%22">De Reuck, J. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Deramecourt%2C+V%2E%22">Deramecourt, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Auger%2C+F%2E%22">Auger, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Durieux%2C+N%2E%22">Durieux, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Cordonnier%2C+C%2E%22">Cordonnier, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Devos%2C+D%2E%22">Devos, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Defebvre%2C+L%2E%22">Defebvre, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Moreau%2C+C%2E%22">Moreau, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Caparros+‐+Lefebvre%2C+D%2E%22">Caparros ‐ Lefebvre, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Leys%2C+D%2E%22">Leys, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Maurage%2C+C%2E+A%2E%22">Maurage, C. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Pasquier%2C+F%2E%22">Pasquier, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Bordet%2C+R%2E%22">Bordet, R.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Jul2014, Vol. 21 Issue 7, p1026-1031. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Iron+in+the+body%22">Iron in the body</searchLink><br /><searchLink fieldCode="DE" term="%22Neurodegeneration%22">Neurodegeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+patients%22">Alzheimer's patients</searchLink><br /><searchLink fieldCode="DE" term="%22Vascular+dementia%22">Vascular dementia</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background and purpose Accumulation of iron (Fe) is often detected in brains of people suffering from neurodegenerative diseases. However, no studies have compared the Fe load between these disease entities. The present study investigates by T2*-weighted gradient-echo 7.0 T magnetic resonance imaging ( MRI) the Fe content in post-mortem brains with different neurodegenerative and cerebrovascular diseases. Methods One hundred and fifty-two post-mortem brains, composed of 46 with Alzheimer's disease ( AD), 37 with frontotemporal lobar degeneration ( FTLD), 11 with amyotrophic lateral sclerosis, 13 with Lewy body disease, 14 with progressive supranuclear palsy, 16 with vascular dementia (VaD) and 15 controls without a brain disease, were examined. The Fe load was determined semi-quantitatively on T2*-weighted MRI serial brain sections in the claustrum, caudate nucleus, putamen, globus pallidus, thalamus, subthalamic nucleus, hippocampus, mamillary body, lateral geniculate body, red nucleus, substantia nigra and dentate nucleus. The disease diagnosis was made on subsequent neuropathological examination. Results The Fe load was significantly increased in the claustrum, caudate nucleus and putamen of FTLD brains and to a lesser degree in the globus pallidus, thalamus and subthalamic nucleus. In the other neurodegenerative diseases no Fe accumulation was observed, except for a mild increase in the caudate nucleus of AD brains. In VaD brains no Fe increase was detected. Conclusions Only FTLD displays a significant Fe load, suggesting that impaired Fe homeostasis plays an important role in the pathogenesis of this heterogeneous disease entity. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ene.12432 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 1026 Subjects: – SubjectFull: Iron in the body Type: general – SubjectFull: Neurodegeneration Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Alzheimer's patients Type: general – SubjectFull: Vascular dementia Type: general – SubjectFull: Patients Type: general Titles: – TitleFull: Iron deposits in post-mortem brains of patients with neurodegenerative and cerebrovascular diseases: a semi-quantitative 7.0 T magnetic resonance imaging study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: De Reuck, J. L. – PersonEntity: Name: NameFull: Deramecourt, V. – PersonEntity: Name: NameFull: Auger, F. – PersonEntity: Name: NameFull: Durieux, N. – PersonEntity: Name: NameFull: Cordonnier, C. – PersonEntity: Name: NameFull: Devos, D. – PersonEntity: Name: NameFull: Defebvre, L. – PersonEntity: Name: NameFull: Moreau, C. – PersonEntity: Name: NameFull: Caparros ‐ Lefebvre, D. – PersonEntity: Name: NameFull: Leys, D. – PersonEntity: Name: NameFull: Maurage, C. A. – PersonEntity: Name: NameFull: Pasquier, F. – PersonEntity: Name: NameFull: Bordet, R. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 13515101 Numbering: – Type: volume Value: 21 – Type: issue Value: 7 Titles: – TitleFull: European Journal of Neurology Type: main |
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