Presynaptic Dopaminergic Function: Implications for Understanding Treatment Response in Psychosis.
Saved in:
| Title: | Presynaptic Dopaminergic Function: Implications for Understanding Treatment Response in Psychosis. |
|---|---|
| Authors: | Bonoldi, I., Howes, O. |
| Source: | CNS Drugs. Jul2014, Vol. 28 Issue 7, p649-663. 15p. 2 Diagrams. |
| Subjects: | Psychiatric treatment, Psychoses, Dopamine receptors, Schizophrenia, Targeted drug delivery, Antipsychotic agents, Neurochemistry |
| Abstract: | All current antipsychotic drugs block dopamine (DA) receptors, but the nature of the DA dysfunction in schizophrenia has not been clear. However, consistent evidence now shows that presynaptic dopaminergic function is altered in schizophrenia, specifically in terms of increased DA synthesis capacity, baseline synaptic DA levels, and DA release. Furthermore, presynaptic dopaminergic function is already elevated in prodromal patients who later developed the disorder. Currently available antipsychotics act on postsynaptic receptors, not targeting presynaptic DA abnormalities. This has implications for understanding response and developing new treatments. The lack of normalization of the abnormal presynaptic function could explain why discontinuation is likely to lead to relapse, because the major dopaminergic function persists, meaning that once treatment stops there is nothing to oppose the dysregulated dopamine function reinstating symptoms. Furthermore, it suggests that drugs that target presynaptic dopaminergic function may constitute new treatment possibilities for schizophrenic patients, in particular, for those in whom antipsychotics are poorly effective. In addition, the longitudinal changes with the onset of psychosis indicate the potential to target a defined dynamic neurochemical abnormality to prevent the onset of psychosis. [ABSTRACT FROM AUTHOR] |
| Copyright of CNS Drugs is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 96871896 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Presynaptic Dopaminergic Function: Implications for Understanding Treatment Response in Psychosis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bonoldi%2C+I%2E%22">Bonoldi, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Howes%2C+O%2E%22">Howes, O.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22CNS+Drugs%22">CNS Drugs</searchLink>. Jul2014, Vol. 28 Issue 7, p649-663. 15p. 2 Diagrams. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Psychiatric+treatment%22">Psychiatric treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine+receptors%22">Dopamine receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Targeted+drug+delivery%22">Targeted drug delivery</searchLink><br /><searchLink fieldCode="DE" term="%22Antipsychotic+agents%22">Antipsychotic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Neurochemistry%22">Neurochemistry</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: All current antipsychotic drugs block dopamine (DA) receptors, but the nature of the DA dysfunction in schizophrenia has not been clear. However, consistent evidence now shows that presynaptic dopaminergic function is altered in schizophrenia, specifically in terms of increased DA synthesis capacity, baseline synaptic DA levels, and DA release. Furthermore, presynaptic dopaminergic function is already elevated in prodromal patients who later developed the disorder. Currently available antipsychotics act on postsynaptic receptors, not targeting presynaptic DA abnormalities. This has implications for understanding response and developing new treatments. The lack of normalization of the abnormal presynaptic function could explain why discontinuation is likely to lead to relapse, because the major dopaminergic function persists, meaning that once treatment stops there is nothing to oppose the dysregulated dopamine function reinstating symptoms. Furthermore, it suggests that drugs that target presynaptic dopaminergic function may constitute new treatment possibilities for schizophrenic patients, in particular, for those in whom antipsychotics are poorly effective. In addition, the longitudinal changes with the onset of psychosis indicate the potential to target a defined dynamic neurochemical abnormality to prevent the onset of psychosis. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of CNS Drugs is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=96871896 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s40263-014-0177-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 649 Subjects: – SubjectFull: Psychiatric treatment Type: general – SubjectFull: Psychoses Type: general – SubjectFull: Dopamine receptors Type: general – SubjectFull: Schizophrenia Type: general – SubjectFull: Targeted drug delivery Type: general – SubjectFull: Antipsychotic agents Type: general – SubjectFull: Neurochemistry Type: general Titles: – TitleFull: Presynaptic Dopaminergic Function: Implications for Understanding Treatment Response in Psychosis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bonoldi, I. – PersonEntity: Name: NameFull: Howes, O. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 11727047 Numbering: – Type: volume Value: 28 – Type: issue Value: 7 Titles: – TitleFull: CNS Drugs Type: main |
| ResultId | 1 |
