Bibliographic Details
| Title: |
ATHEROPROTECTIVE EFFECTS OF HIGH-DENSITY LIPOPROTEINS. |
| Authors: |
Assmann, Gerd, Nofer, Jerzy-Roch |
| Source: |
Annual Review of Medicine. 2003, Vol. 54 Issue 1, p321. 21p. |
| Subjects: |
High density lipoproteins, Arteriosclerosis, Lipoproteins |
| Abstract: |
Observational studies provide overwhelming evidence that a low high-density lipoprotein (HDL)–cholesterol level increases the risk of coronary events, both in healthy subjects and in patients with coronary heart disease. Based on in vitro experiments, several mechanistic explanations for the atheroprotective function of HDL have been suggested. However, few of these were verified in vivo in humans or in experiments with transgenic animals. The HDL functions currently most widely held to account for the antiatherogenic effect include participation in reverse cholesterol transport, protection against endothelial dysfunction, and inhibition of oxidative stress. This review summarizes current views on the molecular mechanism underlying these atheroprotective effects of HDL. [ABSTRACT FROM AUTHOR] |
|
Copyright of Annual Review of Medicine is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Psychology and Behavioral Sciences Collection |
