View in EDS PDF Full Text

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.

Saved in:
Bibliographic Details
Title: Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.
Authors: Lopez-Rios, Javier, Duchesne, Amandine, Speziale, Dario, Andrey, Guillaume, Peterson, Kevin A., Germann, Philipp, Ünal, Erkan, Liu, Jing, Floriot, Sandrine, Barbey, Sarah, Gallard, Yves, Müller-Gerbl, Magdalena, Courtney, Andrew D., Klopp, Christophe, Rodriguez, Sabrina, Ivanek, Robert, Beisel, Christian, Wicking, Carol, Iber, Dagmar, Robert, Benoit
Source: Nature. 7/3/2014, Vol. 511 Issue 7507, p46-51. 6p.
Subjects: Bovine anatomy, Tetrapods, Gene expression, Hedgehog signaling proteins, Receptor-interacting proteins, Growth of the anatomical extremities, Cattle
Abstract: The large spectrum of limb morphologies reflects the wide evolutionary diversification of the basic pentadactyl pattern in tetrapods. In even-toed ungulates (artiodactyls, including cattle), limbs are adapted for running as a consequence of progressive reduction of their distal skeleton to symmetrical and elongated middle digits with hoofed phalanges. Here we analyse bovine embryos to establish that polarized gene expression is progressively lost during limb development in comparison to the mouse. Notably, the transcriptional upregulation of the Ptch1 gene, which encodes a Sonic hedgehog (SHH) receptor, is disrupted specifically in the bovine limb bud mesenchyme. This is due to evolutionary alteration of a Ptch1 cis-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development. Our study provides a molecular explanation for the loss of digit asymmetry in bovine limb buds and suggests that modifications affecting the Ptch1 cis-regulatory landscape have contributed to evolutionary diversification of artiodactyl limbs. [ABSTRACT FROM AUTHOR]
Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 96923481
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Lopez-Rios%2C+Javier%22">Lopez-Rios, Javier</searchLink><br /><searchLink fieldCode="AR" term="%22Duchesne%2C+Amandine%22">Duchesne, Amandine</searchLink><br /><searchLink fieldCode="AR" term="%22Speziale%2C+Dario%22">Speziale, Dario</searchLink><br /><searchLink fieldCode="AR" term="%22Andrey%2C+Guillaume%22">Andrey, Guillaume</searchLink><br /><searchLink fieldCode="AR" term="%22Peterson%2C+Kevin+A%2E%22">Peterson, Kevin A.</searchLink><br /><searchLink fieldCode="AR" term="%22Germann%2C+Philipp%22">Germann, Philipp</searchLink><br /><searchLink fieldCode="AR" term="%22Ünal%2C+Erkan%22">Ünal, Erkan</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Jing%22">Liu, Jing</searchLink><br /><searchLink fieldCode="AR" term="%22Floriot%2C+Sandrine%22">Floriot, Sandrine</searchLink><br /><searchLink fieldCode="AR" term="%22Barbey%2C+Sarah%22">Barbey, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Gallard%2C+Yves%22">Gallard, Yves</searchLink><br /><searchLink fieldCode="AR" term="%22Müller-Gerbl%2C+Magdalena%22">Müller-Gerbl, Magdalena</searchLink><br /><searchLink fieldCode="AR" term="%22Courtney%2C+Andrew+D%2E%22">Courtney, Andrew D.</searchLink><br /><searchLink fieldCode="AR" term="%22Klopp%2C+Christophe%22">Klopp, Christophe</searchLink><br /><searchLink fieldCode="AR" term="%22Rodriguez%2C+Sabrina%22">Rodriguez, Sabrina</searchLink><br /><searchLink fieldCode="AR" term="%22Ivanek%2C+Robert%22">Ivanek, Robert</searchLink><br /><searchLink fieldCode="AR" term="%22Beisel%2C+Christian%22">Beisel, Christian</searchLink><br /><searchLink fieldCode="AR" term="%22Wicking%2C+Carol%22">Wicking, Carol</searchLink><br /><searchLink fieldCode="AR" term="%22Iber%2C+Dagmar%22">Iber, Dagmar</searchLink><br /><searchLink fieldCode="AR" term="%22Robert%2C+Benoit%22">Robert, Benoit</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 7/3/2014, Vol. 511 Issue 7507, p46-51. 6p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Bovine+anatomy%22">Bovine anatomy</searchLink><br /><searchLink fieldCode="DE" term="%22Tetrapods%22">Tetrapods</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Hedgehog+signaling+proteins%22">Hedgehog signaling proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Receptor-interacting+proteins%22">Receptor-interacting proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Growth+of+the+anatomical+extremities%22">Growth of the anatomical extremities</searchLink><br /><searchLink fieldCode="DE" term="%22Cattle%22">Cattle</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The large spectrum of limb morphologies reflects the wide evolutionary diversification of the basic pentadactyl pattern in tetrapods. In even-toed ungulates (artiodactyls, including cattle), limbs are adapted for running as a consequence of progressive reduction of their distal skeleton to symmetrical and elongated middle digits with hoofed phalanges. Here we analyse bovine embryos to establish that polarized gene expression is progressively lost during limb development in comparison to the mouse. Notably, the transcriptional upregulation of the Ptch1 gene, which encodes a Sonic hedgehog (SHH) receptor, is disrupted specifically in the bovine limb bud mesenchyme. This is due to evolutionary alteration of a Ptch1 cis-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development. Our study provides a molecular explanation for the loss of digit asymmetry in bovine limb buds and suggests that modifications affecting the Ptch1 cis-regulatory landscape have contributed to evolutionary diversification of artiodactyl limbs. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=96923481
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/nature13289
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 46
    Subjects:
      – SubjectFull: Bovine anatomy
        Type: general
      – SubjectFull: Tetrapods
        Type: general
      – SubjectFull: Gene expression
        Type: general
      – SubjectFull: Hedgehog signaling proteins
        Type: general
      – SubjectFull: Receptor-interacting proteins
        Type: general
      – SubjectFull: Growth of the anatomical extremities
        Type: general
      – SubjectFull: Cattle
        Type: general
    Titles:
      – TitleFull: Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Lopez-Rios, Javier
      – PersonEntity:
          Name:
            NameFull: Duchesne, Amandine
      – PersonEntity:
          Name:
            NameFull: Speziale, Dario
      – PersonEntity:
          Name:
            NameFull: Andrey, Guillaume
      – PersonEntity:
          Name:
            NameFull: Peterson, Kevin A.
      – PersonEntity:
          Name:
            NameFull: Germann, Philipp
      – PersonEntity:
          Name:
            NameFull: Ünal, Erkan
      – PersonEntity:
          Name:
            NameFull: Liu, Jing
      – PersonEntity:
          Name:
            NameFull: Floriot, Sandrine
      – PersonEntity:
          Name:
            NameFull: Barbey, Sarah
      – PersonEntity:
          Name:
            NameFull: Gallard, Yves
      – PersonEntity:
          Name:
            NameFull: Müller-Gerbl, Magdalena
      – PersonEntity:
          Name:
            NameFull: Courtney, Andrew D.
      – PersonEntity:
          Name:
            NameFull: Klopp, Christophe
      – PersonEntity:
          Name:
            NameFull: Rodriguez, Sabrina
      – PersonEntity:
          Name:
            NameFull: Ivanek, Robert
      – PersonEntity:
          Name:
            NameFull: Beisel, Christian
      – PersonEntity:
          Name:
            NameFull: Wicking, Carol
      – PersonEntity:
          Name:
            NameFull: Iber, Dagmar
      – PersonEntity:
          Name:
            NameFull: Robert, Benoit
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 03
              M: 07
              Text: 7/3/2014
              Type: published
              Y: 2014
          Identifiers:
            – Type: issn-print
              Value: 00280836
          Numbering:
            – Type: volume
              Value: 511
            – Type: issue
              Value: 7507
          Titles:
            – TitleFull: Nature
              Type: main
ResultId 1