Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa.
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| Title: | Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa. |
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| Authors: | Bergen, A W, van den Bree, M B M, Yeager, M, Welch, R, Ganjei, J K, Haque, K, Bacanu, S, Berrettini, W H, Grice, D E, Goldman, D, Bulik, C M, Klump, K, Fichter, M, Halmi, K, Kaplan, A, Strober, M, Treasure, J, Woodside, B, Kaye, W H |
| Source: | Molecular Psychiatry. 2003, Vol. 8 Issue 4, p397. 10p. |
| Subjects: | Anorexia nervosa, Serotonin, Genes, Opioids |
| Abstract: | Serotonergic and opioidergic neurotransmitter system alterations have been observed in people with eating disorders; the genes for the serotonin 1D receptor (HTR1D) and the opioid delta receptor (OPRD1) are found on chr1p36.3-34.3, a region identified by our group in a linkage analysis of anorexia nervosa (AN). These candidate genes were evaluated for sequence variation and for linkage and association of this sequence variation to AN in family and case : control data sets. Resequencing of the HTR1D locus and a portion of the OPRD1 locus identified novel SNPs and confirmed existing SNPs. Genotype assay development and genotyping of nine SNPs (four at HTR1D and five at OPRD1) was performed on 191 unrelated individuals fulfilling DSM-IV criteria (w/o amenorrhea criterion) for AN, 442 relatives of AN probands and 98 psychiatrically screened controls. Linkage analysis of these candidate gene SNPs with 33 microsatellite markers in families including relative pairs concordantly affected with restricting AN (N = 37) substantially increased the evidence for linkage of this region to restricting AN to an NPL score of 3.91. Statistically significant genotypic, allelic, and haplotypic association to AN in the case : control design was observed at HTR1D and OPRD1 with effect sizes for individual SNPs of 2.63 (95% CI=1.21-5.75) for HTR1D and 1.61 (95% CI=1.11-2.44) for OPRD1. Using genotype data on parents and AN probands, three SNPs at HTR1D were found to exhibit significant transmission disequilibrium (P<0.05). The combined statistical genetic evidence suggests that HTR1D and OPRD1 or linked genes may be involved in the etiology of AN. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 9710211 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa<superscript />. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bergen%2C+A+W%22">Bergen, A W</searchLink><br /><searchLink fieldCode="AR" term="%22van+den+Bree%2C+M+B+M%22">van den Bree, M B M</searchLink><br /><searchLink fieldCode="AR" term="%22Yeager%2C+M%22">Yeager, M</searchLink><br /><searchLink fieldCode="AR" term="%22Welch%2C+R%22">Welch, R</searchLink><br /><searchLink fieldCode="AR" term="%22Ganjei%2C+J+K%22">Ganjei, J K</searchLink><br /><searchLink fieldCode="AR" term="%22Haque%2C+K%22">Haque, K</searchLink><br /><searchLink fieldCode="AR" term="%22Bacanu%2C+S%22">Bacanu, S</searchLink><br /><searchLink fieldCode="AR" term="%22Berrettini%2C+W+H%22">Berrettini, W H</searchLink><br /><searchLink fieldCode="AR" term="%22Grice%2C+D+E%22">Grice, D E</searchLink><br /><searchLink fieldCode="AR" term="%22Goldman%2C+D%22">Goldman, D</searchLink><br /><searchLink fieldCode="AR" term="%22Bulik%2C+C+M%22">Bulik, C M</searchLink><br /><searchLink fieldCode="AR" term="%22Klump%2C+K%22">Klump, K</searchLink><br /><searchLink fieldCode="AR" term="%22Fichter%2C+M%22">Fichter, M</searchLink><br /><searchLink fieldCode="AR" term="%22Halmi%2C+K%22">Halmi, K</searchLink><br /><searchLink fieldCode="AR" term="%22Kaplan%2C+A%22">Kaplan, A</searchLink><br /><searchLink fieldCode="AR" term="%22Strober%2C+M%22">Strober, M</searchLink><br /><searchLink fieldCode="AR" term="%22Treasure%2C+J%22">Treasure, J</searchLink><br /><searchLink fieldCode="AR" term="%22Woodside%2C+B%22">Woodside, B</searchLink><br /><searchLink fieldCode="AR" term="%22Kaye%2C+W+H%22">Kaye, W H</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. 2003, Vol. 8 Issue 4, p397. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Anorexia+nervosa%22">Anorexia nervosa</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin%22">Serotonin</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink><br /><searchLink fieldCode="DE" term="%22Opioids%22">Opioids</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Serotonergic and opioidergic neurotransmitter system alterations have been observed in people with eating disorders; the genes for the serotonin 1D receptor (HTR1D) and the opioid delta receptor (OPRD1) are found on chr1p36.3-34.3, a region identified by our group in a linkage analysis of anorexia nervosa (AN). These candidate genes were evaluated for sequence variation and for linkage and association of this sequence variation to AN in family and case : control data sets. Resequencing of the HTR1D locus and a portion of the OPRD1 locus identified novel SNPs and confirmed existing SNPs. Genotype assay development and genotyping of nine SNPs (four at HTR1D and five at OPRD1) was performed on 191 unrelated individuals fulfilling DSM-IV criteria (w/o amenorrhea criterion) for AN, 442 relatives of AN probands and 98 psychiatrically screened controls. Linkage analysis of these candidate gene SNPs with 33 microsatellite markers in families including relative pairs concordantly affected with restricting AN (N = 37) substantially increased the evidence for linkage of this region to restricting AN to an NPL score of 3.91. Statistically significant genotypic, allelic, and haplotypic association to AN in the case : control design was observed at HTR1D and OPRD1 with effect sizes for individual SNPs of 2.63 (95% CI=1.21-5.75) for HTR1D and 1.61 (95% CI=1.11-2.44) for OPRD1. Using genotype data on parents and AN probands, three SNPs at HTR1D were found to exhibit significant transmission disequilibrium (P<0.05). The combined statistical genetic evidence suggests that HTR1D and OPRD1 or linked genes may be involved in the etiology of AN. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/sj.mp.4001318 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 397 Subjects: – SubjectFull: Anorexia nervosa Type: general – SubjectFull: Serotonin Type: general – SubjectFull: Genes Type: general – SubjectFull: Opioids Type: general Titles: – TitleFull: Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bergen, A W – PersonEntity: Name: NameFull: van den Bree, M B M – PersonEntity: Name: NameFull: Yeager, M – PersonEntity: Name: NameFull: Welch, R – PersonEntity: Name: NameFull: Ganjei, J K – PersonEntity: Name: NameFull: Haque, K – PersonEntity: Name: NameFull: Bacanu, S – PersonEntity: Name: NameFull: Berrettini, W H – PersonEntity: Name: NameFull: Grice, D E – PersonEntity: Name: NameFull: Goldman, D – PersonEntity: Name: NameFull: Bulik, C M – PersonEntity: Name: NameFull: Klump, K – PersonEntity: Name: NameFull: Fichter, M – PersonEntity: Name: NameFull: Halmi, K – PersonEntity: Name: NameFull: Kaplan, A – PersonEntity: Name: NameFull: Strober, M – PersonEntity: Name: NameFull: Treasure, J – PersonEntity: Name: NameFull: Woodside, B – PersonEntity: Name: NameFull: Kaye, W H IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: 2003 Type: published Y: 2003 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 8 – Type: issue Value: 4 Titles: – TitleFull: Molecular Psychiatry Type: main |
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