Bibliographic Details
| Title: |
Partitioning the etiology of hoarding and obsessive–compulsive symptoms. |
| Authors: |
Mathews, C. A., Delucchi, K., Cath, D. C., Willemsen, G., Boomsma, D. I. |
| Source: |
Psychological Medicine. Oct2014, Vol. 44 Issue 13, p2867-2876. 10p. |
| Subjects: |
Chi-squared test, Obsessive-compulsive disorder, Self-evaluation, Twins, Phenotypes, Disease prevalence, Data analysis software, Descriptive statistics, Diogenes syndrome, Symptoms, Genetics |
| Geographic Terms: |
Netherlands |
| Abstract: |
BackgroundUntil recently, hoarding was considered an obsessive–compulsive symptom (OCS). However, current evidence suggests that these two phenotypes may be clinically, and perhaps etiologically, distinct. Both hoarding and OCS have a genetic etiology, but the degree of unique and shared genetic contributions to these phenotypes has not been well studied.MethodPrevalence rates were assessed for hoarding and OCS in a sample of adult twin pairs (n = 7906 twins) and their family members from the Netherlands Twin Register (total sample = 15 914). Using Mplus, genetic analyses using liability threshold models were conducted for both phenotypes, for their co-morbidity, and for specific hoarding symptoms (cluttering, discarding and acquiring).ResultsOf the total sample, 6.7% met criteria for clinically significant hoarding; endorsement of all three hoarding symptoms was ⩾79%. Men had slightly higher rates than women. Also, 5.7% met criteria for clinically significant OCS; rates were similar in males and females. Genetic factors accounted for 36% of the variance for hoarding and 40% of the variance for OCS. The genetic correlation between hoarding and OCS was 0.10. There was no evidence of sex-specific genetic contributions for hoarding or OCS. There was evidence for a genetic contribution to all hoarding symptom subtypes. Only cluttering showed evidence of a contribution from the shared environment.ConclusionsOCS and hoarding are common in this population-based sample, have prevalence rates similar to those previously reported, and show significant heritability. Genetic factors contributed to the co-morbidity of both traits, although the genetic correlation between them was low. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
