The association between seizure predisposition and inflammation in a rat model of fatty liver disease.
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| Title: | The association between seizure predisposition and inflammation in a rat model of fatty liver disease. |
|---|---|
| Authors: | Aksoy, Dürdane, Solmaz, Volkan, Taşkıran, Dilek, Erbaş, Oytun |
| Source: | Neurological Sciences. Sep2014, Vol. 35 Issue 9, p1441-1446. 6p. |
| Subjects: | Epilepsy, Inflammation, Fatty liver, Disease susceptibility, Central nervous system diseases, Severity of illness index, Neurosciences |
| Abstract: | The association between inflammation and the induction of seizures is well-known. It has been reported that non-alcoholic fatty liver disease (NAFLD) is associated with a pro-inflammatory state, and systemic inflammation may trigger central nervous system inflammation. This study aims to identify the impact of inflammation in a rat model of fatty liver on the propensity and severity of pentylenetetrazol (PTZ)-induced seizures. Twenty-four male Sprague-Dawley rats were divided into four groups. Groups 1 and 2 were administered a 35 % fructose solution over 8 weeks to induce the development of fatty liver while Groups 3 and 4 were fed normally as controls. Groups 1 and 3 were given 70 mg/kg PTZ, determining Racine Convulsion Scores (RCS) and onset times of the first myoclonic jerks (FMJ). Groups 2 and 4 were administered 35 mg/kg of PTZ, then EEG recordings were obtained to evaluate spike percentages. TNF-α levels in brain and liver tissues were also measured. While RCS's of fatty liver rats were higher than the control group ( p > 0.05) as well as spike percentages ( p < 0.05), FMJ onset time was significantly shorter. TNF-α levels in liver and brain tissues of the rats with NAFLD were significantly higher than the control rats. We found that rats with NAFLD demonstrated decreased seizure thresholds, possibly due to increased cytokine levels systemically and within the central nervous system. As such, epilepsy patients taking medications that may predispose the development of NAFLD must be carefully managed to prevent the possibility of increased seizure episodes. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 97680261 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The association between seizure predisposition and inflammation in a rat model of fatty liver disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Aksoy%2C+Dürdane%22">Aksoy, Dürdane</searchLink><br /><searchLink fieldCode="AR" term="%22Solmaz%2C+Volkan%22">Solmaz, Volkan</searchLink><br /><searchLink fieldCode="AR" term="%22Taşkıran%2C+Dilek%22">Taşkıran, Dilek</searchLink><br /><searchLink fieldCode="AR" term="%22Erbaş%2C+Oytun%22">Erbaş, Oytun</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Sep2014, Vol. 35 Issue 9, p1441-1446. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Fatty+liver%22">Fatty liver</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+susceptibility%22">Disease susceptibility</searchLink><br /><searchLink fieldCode="DE" term="%22Central+nervous+system+diseases%22">Central nervous system diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Severity+of+illness+index%22">Severity of illness index</searchLink><br /><searchLink fieldCode="DE" term="%22Neurosciences%22">Neurosciences</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The association between inflammation and the induction of seizures is well-known. It has been reported that non-alcoholic fatty liver disease (NAFLD) is associated with a pro-inflammatory state, and systemic inflammation may trigger central nervous system inflammation. This study aims to identify the impact of inflammation in a rat model of fatty liver on the propensity and severity of pentylenetetrazol (PTZ)-induced seizures. Twenty-four male Sprague-Dawley rats were divided into four groups. Groups 1 and 2 were administered a 35 % fructose solution over 8 weeks to induce the development of fatty liver while Groups 3 and 4 were fed normally as controls. Groups 1 and 3 were given 70 mg/kg PTZ, determining Racine Convulsion Scores (RCS) and onset times of the first myoclonic jerks (FMJ). Groups 2 and 4 were administered 35 mg/kg of PTZ, then EEG recordings were obtained to evaluate spike percentages. TNF-α levels in brain and liver tissues were also measured. While RCS's of fatty liver rats were higher than the control group ( p > 0.05) as well as spike percentages ( p < 0.05), FMJ onset time was significantly shorter. TNF-α levels in liver and brain tissues of the rats with NAFLD were significantly higher than the control rats. We found that rats with NAFLD demonstrated decreased seizure thresholds, possibly due to increased cytokine levels systemically and within the central nervous system. As such, epilepsy patients taking medications that may predispose the development of NAFLD must be carefully managed to prevent the possibility of increased seizure episodes. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-014-1778-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 1441 Subjects: – SubjectFull: Epilepsy Type: general – SubjectFull: Inflammation Type: general – SubjectFull: Fatty liver Type: general – SubjectFull: Disease susceptibility Type: general – SubjectFull: Central nervous system diseases Type: general – SubjectFull: Severity of illness index Type: general – SubjectFull: Neurosciences Type: general Titles: – TitleFull: The association between seizure predisposition and inflammation in a rat model of fatty liver disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Aksoy, Dürdane – PersonEntity: Name: NameFull: Solmaz, Volkan – PersonEntity: Name: NameFull: Taşkıran, Dilek – PersonEntity: Name: NameFull: Erbaş, Oytun IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 35 – Type: issue Value: 9 Titles: – TitleFull: Neurological Sciences Type: main |
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