Acute administration of THC impairs spatial but not associative memory function in zebrafish.
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| Title: | Acute administration of THC impairs spatial but not associative memory function in zebrafish. |
|---|---|
| Authors: | Ruhl, Tim, Prinz, Nicole, Oellers, Nadine, Seidel, Nathan, Jonas, Annika, Albayram, Önder, Bilkei-Gorzo, Andras, Emde, Gerhard |
| Source: | Psychopharmacology. Oct2014, Vol. 231 Issue 19, p3829-3842. 14p. 3 Diagrams, 3 Graphs. |
| Subjects: | Zebra danio, Tetrahydrocannabinol, Spatial memory, Associative memory (Psychology), Psychopharmacological research, Flashbacks (Memory), Cannabinoids, Telencephalon |
| Abstract: | Rationale: The present study examined the effect of acute administration of endocannabinoid receptor CB1 ligand ∆-9-tetrahydrocannabinol (THC) on intracellular signalling in the brain and retrieval from two different memory systems in the zebrafish ( Danio rerio). Methods: First, fish were treated with THC and changes in the phosphorylation level of mitogen-activated protein (MAP) kinases Akt and Erk in the brain were determined 1 h after drug treatment. Next, animals of a second group learned in a two-alternative choice paradigm to discriminate between two colours, whereas a third group solved a spatial cognition task in an open-field maze by use of an ego-allocentric strategy. After memory acquisition and consolidation, animals were pharmacologically treated using the treatment regime as in the first group and then tested again for memory retrieval. Results: We found an enhanced Erk but not Akt phosphorylation suggesting that THC treatment specifically activated Erk signalling in the zebrafish telencephalon. While CB1 agonist THC did not affect behavioural performance of animals in the colour discrimination paradigm, spatial memory was significantly impaired. The effect of THC on spatial learning is probably specific, since neither motor activity nor anxiety-related behaviour was influenced by the drug treatment. That indicates a striking influence of the endocannabinoid system (ECS) on spatial cognition in zebrafish. Conclusions: The results are very coincident with reports on mammals, demonstrating that the ECS is functional highly conserved during vertebrate evolution. We further conclude that the zebrafish provides a promising model organism for ongoing research on the ECS. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 98020595 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Acute administration of THC impairs spatial but not associative memory function in zebrafish. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ruhl%2C+Tim%22">Ruhl, Tim</searchLink><br /><searchLink fieldCode="AR" term="%22Prinz%2C+Nicole%22">Prinz, Nicole</searchLink><br /><searchLink fieldCode="AR" term="%22Oellers%2C+Nadine%22">Oellers, Nadine</searchLink><br /><searchLink fieldCode="AR" term="%22Seidel%2C+Nathan%22">Seidel, Nathan</searchLink><br /><searchLink fieldCode="AR" term="%22Jonas%2C+Annika%22">Jonas, Annika</searchLink><br /><searchLink fieldCode="AR" term="%22Albayram%2C+Önder%22">Albayram, Önder</searchLink><br /><searchLink fieldCode="AR" term="%22Bilkei-Gorzo%2C+Andras%22">Bilkei-Gorzo, Andras</searchLink><br /><searchLink fieldCode="AR" term="%22Emde%2C+Gerhard%22">Emde, Gerhard</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Oct2014, Vol. 231 Issue 19, p3829-3842. 14p. 3 Diagrams, 3 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Zebra+danio%22">Zebra danio</searchLink><br /><searchLink fieldCode="DE" term="%22Tetrahydrocannabinol%22">Tetrahydrocannabinol</searchLink><br /><searchLink fieldCode="DE" term="%22Spatial+memory%22">Spatial memory</searchLink><br /><searchLink fieldCode="DE" term="%22Associative+memory+%28Psychology%29%22">Associative memory (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Psychopharmacological+research%22">Psychopharmacological research</searchLink><br /><searchLink fieldCode="DE" term="%22Flashbacks+%28Memory%29%22">Flashbacks (Memory)</searchLink><br /><searchLink fieldCode="DE" term="%22Cannabinoids%22">Cannabinoids</searchLink><br /><searchLink fieldCode="DE" term="%22Telencephalon%22">Telencephalon</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: The present study examined the effect of acute administration of endocannabinoid receptor CB1 ligand ∆-9-tetrahydrocannabinol (THC) on intracellular signalling in the brain and retrieval from two different memory systems in the zebrafish ( Danio rerio). Methods: First, fish were treated with THC and changes in the phosphorylation level of mitogen-activated protein (MAP) kinases Akt and Erk in the brain were determined 1 h after drug treatment. Next, animals of a second group learned in a two-alternative choice paradigm to discriminate between two colours, whereas a third group solved a spatial cognition task in an open-field maze by use of an ego-allocentric strategy. After memory acquisition and consolidation, animals were pharmacologically treated using the treatment regime as in the first group and then tested again for memory retrieval. Results: We found an enhanced Erk but not Akt phosphorylation suggesting that THC treatment specifically activated Erk signalling in the zebrafish telencephalon. While CB1 agonist THC did not affect behavioural performance of animals in the colour discrimination paradigm, spatial memory was significantly impaired. The effect of THC on spatial learning is probably specific, since neither motor activity nor anxiety-related behaviour was influenced by the drug treatment. That indicates a striking influence of the endocannabinoid system (ECS) on spatial cognition in zebrafish. Conclusions: The results are very coincident with reports on mammals, demonstrating that the ECS is functional highly conserved during vertebrate evolution. We further conclude that the zebrafish provides a promising model organism for ongoing research on the ECS. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-014-3522-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 3829 Subjects: – SubjectFull: Zebra danio Type: general – SubjectFull: Tetrahydrocannabinol Type: general – SubjectFull: Spatial memory Type: general – SubjectFull: Associative memory (Psychology) Type: general – SubjectFull: Psychopharmacological research Type: general – SubjectFull: Flashbacks (Memory) Type: general – SubjectFull: Cannabinoids Type: general – SubjectFull: Telencephalon Type: general Titles: – TitleFull: Acute administration of THC impairs spatial but not associative memory function in zebrafish. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ruhl, Tim – PersonEntity: Name: NameFull: Prinz, Nicole – PersonEntity: Name: NameFull: Oellers, Nadine – PersonEntity: Name: NameFull: Seidel, Nathan – PersonEntity: Name: NameFull: Jonas, Annika – PersonEntity: Name: NameFull: Albayram, Önder – PersonEntity: Name: NameFull: Bilkei-Gorzo, Andras – PersonEntity: Name: NameFull: Emde, Gerhard IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 231 – Type: issue Value: 19 Titles: – TitleFull: Psychopharmacology Type: main |
| ResultId | 1 |
