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Rapid dopamine transmission within the nucleus accumbens: Dramatic difference between morphine and oxycodone delivery.

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Title: Rapid dopamine transmission within the nucleus accumbens: Dramatic difference between morphine and oxycodone delivery.
Authors: Vander Weele, Caitlin M., Porter‐Stransky, Kirsten A., Mabrouk, Omar S., Lovic, Vedran, Singer, Bryan F., Kennedy, Robert T., Aragona, Brandon J.
Source: European Journal of Neuroscience. Oct2014, Vol. 40 Issue 7, p3041-3054. 14p.
Subjects: Dopamine, Oxycodone, Morphine, Cyclic voltammetry, High performance liquid chromatography, Tandem mass spectrometry
Abstract: While most drugs of abuse increase dopamine neurotransmission, rapid neurochemical measurements show that different drugs evoke distinct dopamine release patterns within the nucleus accumbens. Rapid changes in dopamine concentration following psychostimulant administration have been well studied; however, such changes have never been examined following opioid delivery. Here, we provide novel measures of rapid dopamine release following intravenous infusion of two opioids, morphine and oxycodone, in drug-naïve rats using fast-scan cyclic voltammetry and rapid (1 min) microdialysis coupled with high-performance liquid chromatography - tandem mass spectrometry ( HPLC- MS). In addition to measuring rapid dopamine transmission, microdialysis HPLC- MS measures changes in GABA, glutamate, monoamines, monoamine metabolites and several other neurotransmitters. Although both opioids increased dopamine release in the nucleus accumbens, their patterns of drug-evoked dopamine transmission differed dramatically. Oxycodone evoked a robust and stable increase in dopamine concentration and a robust increase in the frequency and amplitude of phasic dopamine release events. Conversely, morphine evoked a brief (~ 1 min) increase in dopamine that was coincident with a surge in GABA concentration and then both transmitters returned to baseline levels. Thus, by providing rapid measures of neurotransmission, this study reveals previously unknown differences in opioid-induced neurotransmitter signaling. Investigating these differences may be essential for understanding how these two drugs of abuse could differentially usurp motivational circuitry and powerfully influence behavior. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Rapid dopamine transmission within the nucleus accumbens: Dramatic difference between morphine and oxycodone delivery.
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  Data: <searchLink fieldCode="AR" term="%22Vander+Weele%2C+Caitlin+M%2E%22">Vander Weele, Caitlin M.</searchLink><br /><searchLink fieldCode="AR" term="%22Porter‐Stransky%2C+Kirsten+A%2E%22">Porter‐Stransky, Kirsten A.</searchLink><br /><searchLink fieldCode="AR" term="%22Mabrouk%2C+Omar+S%2E%22">Mabrouk, Omar S.</searchLink><br /><searchLink fieldCode="AR" term="%22Lovic%2C+Vedran%22">Lovic, Vedran</searchLink><br /><searchLink fieldCode="AR" term="%22Singer%2C+Bryan+F%2E%22">Singer, Bryan F.</searchLink><br /><searchLink fieldCode="AR" term="%22Kennedy%2C+Robert+T%2E%22">Kennedy, Robert T.</searchLink><br /><searchLink fieldCode="AR" term="%22Aragona%2C+Brandon+J%2E%22">Aragona, Brandon J.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Oct2014, Vol. 40 Issue 7, p3041-3054. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Oxycodone%22">Oxycodone</searchLink><br /><searchLink fieldCode="DE" term="%22Morphine%22">Morphine</searchLink><br /><searchLink fieldCode="DE" term="%22Cyclic+voltammetry%22">Cyclic voltammetry</searchLink><br /><searchLink fieldCode="DE" term="%22High+performance+liquid+chromatography%22">High performance liquid chromatography</searchLink><br /><searchLink fieldCode="DE" term="%22Tandem+mass+spectrometry%22">Tandem mass spectrometry</searchLink>
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  Data: While most drugs of abuse increase dopamine neurotransmission, rapid neurochemical measurements show that different drugs evoke distinct dopamine release patterns within the nucleus accumbens. Rapid changes in dopamine concentration following psychostimulant administration have been well studied; however, such changes have never been examined following opioid delivery. Here, we provide novel measures of rapid dopamine release following intravenous infusion of two opioids, morphine and oxycodone, in drug-naïve rats using fast-scan cyclic voltammetry and rapid (1 min) microdialysis coupled with high-performance liquid chromatography - tandem mass spectrometry ( HPLC- MS). In addition to measuring rapid dopamine transmission, microdialysis HPLC- MS measures changes in GABA, glutamate, monoamines, monoamine metabolites and several other neurotransmitters. Although both opioids increased dopamine release in the nucleus accumbens, their patterns of drug-evoked dopamine transmission differed dramatically. Oxycodone evoked a robust and stable increase in dopamine concentration and a robust increase in the frequency and amplitude of phasic dopamine release events. Conversely, morphine evoked a brief (~ 1 min) increase in dopamine that was coincident with a surge in GABA concentration and then both transmitters returned to baseline levels. Thus, by providing rapid measures of neurotransmission, this study reveals previously unknown differences in opioid-induced neurotransmitter signaling. Investigating these differences may be essential for understanding how these two drugs of abuse could differentially usurp motivational circuitry and powerfully influence behavior. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ejn.12709
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      – SubjectFull: Tandem mass spectrometry
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      – TitleFull: Rapid dopamine transmission within the nucleus accumbens: Dramatic difference between morphine and oxycodone delivery.
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              Text: Oct2014
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