IL-5 and Eotaxin Levels in Middle Ear Effusion and Blood from Asthmatics with Otitis Media with Effusion.
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| Title: | IL-5 and Eotaxin Levels in Middle Ear Effusion and Blood from Asthmatics with Otitis Media with Effusion. |
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| Authors: | Nonaka, Manabu, Fukumoto, Akira, Ozu, Chika, Mokuno, Eriko, Baba, Shunkichi, Pawankar, Ruby, Yagi, Toshiaki |
| Source: | Acta Oto-Laryngologica. Apr2003, Vol. 123 Issue 3, p383-387. 5p. |
| Subjects: | Middle ear diseases, Otitis media |
| Abstract: | Objective The purpose of this study was to evaluate eosinophil infiltration as well as IL-5 and eotaxin levels in middle ear effusion (MEE) and blood from otitis media with effusion (OME) patients with asthma and to compare the findings with those from OME patients without asthma (control group). Material and methods Levels of IL-5 and eotaxin in MEE and blood were measured by means of enzyme-linked immunosorbent assay. Results—IL-5 levels in MEE were significantly higher than those in blood in both groups of patients and in OME patients with asthma than in the control group. In addition, in OME patients with asthma, there was a significant correlation between the percentage of eosinophils and IL-5 levels in MEE. Eotaxin levels in blood were significantly higher than those in MEE in both groups of patients and in OME patients with asthma than in the control group. In addition, in OME patients with asthma, the percentage of eosinophils and eotaxin levels in blood tended to correlate, but did not reach statistical significance. Conclusion—These data suggest that, in OME patients with asthma, eosinophilia in MEE depends more on IL-5 than on eotaxin, and that eotaxin may play an important role in the mobilization of eosinophils from the bone marrow into the blood. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 9904092 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: IL-5 and Eotaxin Levels in Middle Ear Effusion and Blood from Asthmatics with Otitis Media with Effusion. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Nonaka%2C+Manabu%22">Nonaka, Manabu</searchLink><br /><searchLink fieldCode="AR" term="%22Fukumoto%2C+Akira%22">Fukumoto, Akira</searchLink><br /><searchLink fieldCode="AR" term="%22Ozu%2C+Chika%22">Ozu, Chika</searchLink><br /><searchLink fieldCode="AR" term="%22Mokuno%2C+Eriko%22">Mokuno, Eriko</searchLink><br /><searchLink fieldCode="AR" term="%22Baba%2C+Shunkichi%22">Baba, Shunkichi</searchLink><br /><searchLink fieldCode="AR" term="%22Pawankar%2C+Ruby%22">Pawankar, Ruby</searchLink><br /><searchLink fieldCode="AR" term="%22Yagi%2C+Toshiaki%22">Yagi, Toshiaki</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Apr2003, Vol. 123 Issue 3, p383-387. 5p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Middle+ear+diseases%22">Middle ear diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Otitis+media%22">Otitis media</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective The purpose of this study was to evaluate eosinophil infiltration as well as IL-5 and eotaxin levels in middle ear effusion (MEE) and blood from otitis media with effusion (OME) patients with asthma and to compare the findings with those from OME patients without asthma (control group). Material and methods Levels of IL-5 and eotaxin in MEE and blood were measured by means of enzyme-linked immunosorbent assay. Results—IL-5 levels in MEE were significantly higher than those in blood in both groups of patients and in OME patients with asthma than in the control group. In addition, in OME patients with asthma, there was a significant correlation between the percentage of eosinophils and IL-5 levels in MEE. Eotaxin levels in blood were significantly higher than those in MEE in both groups of patients and in OME patients with asthma than in the control group. In addition, in OME patients with asthma, the percentage of eosinophils and eotaxin levels in blood tended to correlate, but did not reach statistical significance. Conclusion—These data suggest that, in OME patients with asthma, eosinophilia in MEE depends more on IL-5 than on eotaxin, and that eotaxin may play an important role in the mobilization of eosinophils from the bone marrow into the blood. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/0036554021000028117 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 383 Subjects: – SubjectFull: Middle ear diseases Type: general – SubjectFull: Otitis media Type: general Titles: – TitleFull: IL-5 and Eotaxin Levels in Middle Ear Effusion and Blood from Asthmatics with Otitis Media with Effusion. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nonaka, Manabu – PersonEntity: Name: NameFull: Fukumoto, Akira – PersonEntity: Name: NameFull: Ozu, Chika – PersonEntity: Name: NameFull: Mokuno, Eriko – PersonEntity: Name: NameFull: Baba, Shunkichi – PersonEntity: Name: NameFull: Pawankar, Ruby – PersonEntity: Name: NameFull: Yagi, Toshiaki IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2003 Type: published Y: 2003 Identifiers: – Type: issn-print Value: 00016489 Numbering: – Type: volume Value: 123 – Type: issue Value: 3 Titles: – TitleFull: Acta Oto-Laryngologica Type: main |
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