Compromised frontocerebellar circuitry contributes to nonplanning impulsivity in recovering alcoholics.
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| Title: | Compromised frontocerebellar circuitry contributes to nonplanning impulsivity in recovering alcoholics. |
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| Authors: | Jung, Young-Chul, Schulte, Tilman, Müller-Oehring, Eva, Namkoong, Kee, Pfefferbaum, Adolf, Sullivan, Edith |
| Source: | Psychopharmacology. Dec2014, Vol. 231 Issue 23, p4443-4453. 11p. 1 Color Photograph, 1 Diagram, 4 Charts, 3 Graphs. |
| Subjects: | Impulsive personality, People in recovery from alcoholism, Cingulate cortex, Cerebellum, Alcoholism, Functional magnetic resonance imaging, Decision making, Control groups |
| Abstract: | Rationale: Degradation of frontocerebellar circuitry is a principal neural mechanism of alcoholism-related executive dysfunctions affecting impulse control and cognitive planning. Objective: We tested the hypothesis that alcoholic patients would demonstrate compromised dorsal anterior cingulate cortex (dACC) -cerebellar functional connectivity when adjusting their strategies to accommodate uncertain conditions and would recruit compensatory brain regions to overcome ineffective response patterns. Methods: Twenty-six alcoholics and 26 healthy participants underwent functional MRI in two sequential runs while performing a decision-making task. The first run required a response regardless of level of ambiguity of the stimuli; the second run allowed a PASS option (i.e., no response choice), which was useful on ambiguous trials. Results: Healthy controls demonstrated strong synchronous activity between the dACC and cerebellum while planning and executing a behavioral strategy. By contrast, alcoholics showed synchronous activity between the dACC and the premotor cortex, perhaps enabling successful compensation for accuracy and reaction time in certain conditions; however, a negative outcome of this strategy was rigidity in modifying response strategy to accommodate uncertain conditions. Compared with the alcoholic group, the control group had lower nonplanning impulsiveness, which correlated with using the option PASS to respond in uncertain conditions. Conclusion: These findings suggest that compromised dACC-cerebellar functional circuitry contributes to recruitment of an alternative network-dACC-premotor cortex- to perform well under low-risk, unambiguous conditions. This compensatory network, however, was inadequate to enable the alcoholics to avert making poor choices in planning and executing an effective behavioral strategy in high-risk, uncertain conditions. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 99255700 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Compromised frontocerebellar circuitry contributes to nonplanning impulsivity in recovering alcoholics. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Jung%2C+Young-Chul%22">Jung, Young-Chul</searchLink><br /><searchLink fieldCode="AR" term="%22Schulte%2C+Tilman%22">Schulte, Tilman</searchLink><br /><searchLink fieldCode="AR" term="%22Müller-Oehring%2C+Eva%22">Müller-Oehring, Eva</searchLink><br /><searchLink fieldCode="AR" term="%22Namkoong%2C+Kee%22">Namkoong, Kee</searchLink><br /><searchLink fieldCode="AR" term="%22Pfefferbaum%2C+Adolf%22">Pfefferbaum, Adolf</searchLink><br /><searchLink fieldCode="AR" term="%22Sullivan%2C+Edith%22">Sullivan, Edith</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Dec2014, Vol. 231 Issue 23, p4443-4453. 11p. 1 Color Photograph, 1 Diagram, 4 Charts, 3 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Impulsive+personality%22">Impulsive personality</searchLink><br /><searchLink fieldCode="DE" term="%22People+in+recovery+from+alcoholism%22">People in recovery from alcoholism</searchLink><br /><searchLink fieldCode="DE" term="%22Cingulate+cortex%22">Cingulate cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebellum%22">Cerebellum</searchLink><br /><searchLink fieldCode="DE" term="%22Alcoholism%22">Alcoholism</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Decision+making%22">Decision making</searchLink><br /><searchLink fieldCode="DE" term="%22Control+groups%22">Control groups</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Degradation of frontocerebellar circuitry is a principal neural mechanism of alcoholism-related executive dysfunctions affecting impulse control and cognitive planning. Objective: We tested the hypothesis that alcoholic patients would demonstrate compromised dorsal anterior cingulate cortex (dACC) -cerebellar functional connectivity when adjusting their strategies to accommodate uncertain conditions and would recruit compensatory brain regions to overcome ineffective response patterns. Methods: Twenty-six alcoholics and 26 healthy participants underwent functional MRI in two sequential runs while performing a decision-making task. The first run required a response regardless of level of ambiguity of the stimuli; the second run allowed a PASS option (i.e., no response choice), which was useful on ambiguous trials. Results: Healthy controls demonstrated strong synchronous activity between the dACC and cerebellum while planning and executing a behavioral strategy. By contrast, alcoholics showed synchronous activity between the dACC and the premotor cortex, perhaps enabling successful compensation for accuracy and reaction time in certain conditions; however, a negative outcome of this strategy was rigidity in modifying response strategy to accommodate uncertain conditions. Compared with the alcoholic group, the control group had lower nonplanning impulsiveness, which correlated with using the option PASS to respond in uncertain conditions. Conclusion: These findings suggest that compromised dACC-cerebellar functional circuitry contributes to recruitment of an alternative network-dACC-premotor cortex- to perform well under low-risk, unambiguous conditions. This compensatory network, however, was inadequate to enable the alcoholics to avert making poor choices in planning and executing an effective behavioral strategy in high-risk, uncertain conditions. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-014-3594-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 4443 Subjects: – SubjectFull: Impulsive personality Type: general – SubjectFull: People in recovery from alcoholism Type: general – SubjectFull: Cingulate cortex Type: general – SubjectFull: Cerebellum Type: general – SubjectFull: Alcoholism Type: general – SubjectFull: Functional magnetic resonance imaging Type: general – SubjectFull: Decision making Type: general – SubjectFull: Control groups Type: general Titles: – TitleFull: Compromised frontocerebellar circuitry contributes to nonplanning impulsivity in recovering alcoholics. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jung, Young-Chul – PersonEntity: Name: NameFull: Schulte, Tilman – PersonEntity: Name: NameFull: Müller-Oehring, Eva – PersonEntity: Name: NameFull: Namkoong, Kee – PersonEntity: Name: NameFull: Pfefferbaum, Adolf – PersonEntity: Name: NameFull: Sullivan, Edith IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 231 – Type: issue Value: 23 Titles: – TitleFull: Psychopharmacology Type: main |
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