Vitamin D and white matter abnormalities in older adults: a cross-sectional neuroimaging study.
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| Title: | Vitamin D and white matter abnormalities in older adults: a cross-sectional neuroimaging study. |
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| Authors: | Annweiler, C., Annweiler, T., Bartha, R., Herrmann, F. R., Camicioli, R., Beauchet, O. |
| Source: | European Journal of Neurology. Dec2014, Vol. 21 Issue 12, p1436-1436. 9p. 2 Charts, 1 Graph. |
| Subjects: | Physiological effects of vitamin D, Leukoaraiosis, Diseases in adults, Magnetic resonance imaging of the brain, Hydrocephalus, Brain imaging |
| Abstract: | Background and purpose Morphological brain changes related to hypovitaminosis D have been poorly studied. In particular, the age-related decrease in vitamin D concentrations may explain the onset of white matter abnormalities ( WMA) in older adults. Our objectives were (i) to investigate whether there was an association between serum 25-hydroxyvitamin D (25 OHD) concentration and the grade of WMA in older adults and (ii) to determine whether the location of WMA was associated with 25 OHD concentration. Methods One hundred and thirty-three Caucasian older community-dwellers with no clinical hydrocephalus (mean 71.6 ± 5.6 years; 43.6% female) received a blood test and a magnetic resonance imaging scan of the brain. The grades of total, periventricular and deep WMA were scored using semiquantitative visual rating scales from T2-weighted fluid-attenuated inversion recovery images. The association of WMA with as-measured and deseasonalized 25 OHD concentrations was evaluated with the following covariates: age, gender, body mass index, use of anti-vascular drugs, number of comorbidities, impaired mobility, education level, Mini-Mental State Examination score, medial temporal lobe atrophy, serum concentrations of calcium, thyroid-stimulating hormone and vitamin B12, and estimated glomerular filtration rate. Results Both as-measured and deseasonalized serum 25 OHD concentrations were found to be inversely associated with the grade of total WMA (adjusted β = −0.32, P = 0.027), specifically with periventricular WMA (adjusted β = −0.15, P = 0.009) but not with deep WMA (adjusted β = −0.12, P = 0.090). Similarly, participants with 25 OHD concentration <75 nM had on average a 33% higher grade of periventricular WMA than those with 25 OHD ≥75 nM ( P = 0.024). No difference in average grade was found for deep WMA ( P = 0.949). Conclusions Lower serum 25 OHD concentration was associated with higher grade of WMA, particularly periventricular WMA. These findings provide a scientific basis for vitamin D replacement trials. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Background and purpose Morphological brain changes related to hypovitaminosis D have been poorly studied. In particular, the age-related decrease in vitamin D concentrations may explain the onset of white matter abnormalities ( WMA) in older adults. Our objectives were (i) to investigate whether there was an association between serum 25-hydroxyvitamin D (25 OHD) concentration and the grade of WMA in older adults and (ii) to determine whether the location of WMA was associated with 25 OHD concentration. Methods One hundred and thirty-three Caucasian older community-dwellers with no clinical hydrocephalus (mean 71.6 ± 5.6 years; 43.6% female) received a blood test and a magnetic resonance imaging scan of the brain. The grades of total, periventricular and deep WMA were scored using semiquantitative visual rating scales from T2-weighted fluid-attenuated inversion recovery images. The association of WMA with as-measured and deseasonalized 25 OHD concentrations was evaluated with the following covariates: age, gender, body mass index, use of anti-vascular drugs, number of comorbidities, impaired mobility, education level, Mini-Mental State Examination score, medial temporal lobe atrophy, serum concentrations of calcium, thyroid-stimulating hormone and vitamin B12, and estimated glomerular filtration rate. Results Both as-measured and deseasonalized serum 25 OHD concentrations were found to be inversely associated with the grade of total WMA (adjusted β = −0.32, P = 0.027), specifically with periventricular WMA (adjusted β = −0.15, P = 0.009) but not with deep WMA (adjusted β = −0.12, P = 0.090). Similarly, participants with 25 OHD concentration <75 nM had on average a 33% higher grade of periventricular WMA than those with 25 OHD ≥75 nM ( P = 0.024). No difference in average grade was found for deep WMA ( P = 0.949). Conclusions Lower serum 25 OHD concentration was associated with higher grade of WMA, particularly periventricular WMA. These findings provide a scientific basis for vitamin D replacement trials. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 13515101 |
| DOI: | 10.1111/ene.12511 |
